DEXMEDETOMIDINE

This study tests whether a medicine given as a nose spray before a heart procedure can reduce heart muscle damage or heart attacks. About 1800 adults with coronary heart disease will receive either the spray or a placebo 15 minutes before their procedure. Researchers will check b…

This study tests whether giving older patients (65-90) a combination of two medicines (dexmedetomidine and esketamine) plus a gentle brain stimulation technique (tDCS) around the time of surgery can prevent confusion, memory loss, and other thinking problems that often occur afte…

This study looks at whether giving older adults (65-90) a combination of two drugs (dexmedetomidine and esketamine) along with a gentle brain stimulation technique (tDCS) before non-cardiac surgery can prevent long-term memory and thinking problems. About 1160 participants with m…

This study looks for the best way to sedate children aged 1 to 12 during an MRI. It compares using propofol alone versus adding a small dose of dexmedetomidine, which may reduce side effects and recovery time. About 105 children will take part to find the safest and most effectiv…

This study tests whether combining two sedative drugs (esketamine and dexmedetomidine) can safely reduce the time ICU patients spend in a confused, agitated state called hyperactive delirium. About 132 adults on non-invasive breathing support will receive either the drug combo or…

This study tests whether a nasal spray containing dexmedetomidine can safely sedate patients before surgery with minimal monitoring. About 564 adults will receive either the spray or a placebo 45 minutes before anesthesia. Researchers will track breathing and heart problems, how …

This study looks at whether giving dexamethasone and dexmedetomidine, alone or together, can help the gut work better after laparoscopic gallbladder removal. About 160 adults having this surgery will be randomly assigned to receive one of these drugs, both, or a placebo right aft…

This study tests whether giving a combination of two drugs, dexmedetomidine and esketamine, before and after spinal surgery can lower the chance of moderate-to-severe pain in the first three days after the operation. About 274 adults aged 40 to 79 having spine surgery will take p…

This study tests whether giving two drugs together during spinal surgery can lower the chance of long-term pain. About 274 adults aged 40-79 having spine surgery will receive either the drug combo or a placebo. The goal is to see if fewer people have pain 3 to 6 months after surg…

This study looks at whether avoiding opioids during anesthesia can help elderly patients recover faster after coronary artery bypass surgery. Researchers will compare opioid-free anesthesia to standard opioid-based anesthesia in 60 patients aged 65 and older. The goal is to see i…

This study tests adding dexmedetomidine or clonidine to standard spinal anesthesia for C-sections. The goal is to reduce uncomfortable pulling or pressure sensations during surgery and improve pain relief afterward. About 150 pregnant women having a C-section will take part.