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Mindfulness may rewire depressed brains, small study hints

NCT ID NCT05585775

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jul 07, 2026 · Updated 3 times

Summary

This study looks at whether mindfulness-based cognitive therapy (MBCT) can improve how the brain controls emotions in people with mild depression symptoms. 76 adults with depression in remission will be randomly assigned to either MBCT or a wellness program. Researchers will use computer tasks and surveys to measure changes in emotional thinking and mood over time.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Mindfulness-Based Cognitive Therapy (MBCT)
What this could lead to
If successful, this could reveal how MBCT works in the brain to ease depression, pointing toward more targeted treatments.
What could go wrong
This is a small, early-stage study focused on brain processes, not a direct treatment test. Results may not lead to new therapies or apply to everyone with depression.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 76 people

The number the study aims to enrol. It can still change while the study runs.

Started

Apr 2023

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Adults 18 years or older 2. English fluency in order to complete study procedures 3. Normal vision or corrected to normal vision 4. QIDS score ≥ 5 and ≤ 15 to include individuals with elevated, but not severe symptoms of depression 5. No presence of psychotic symptoms that interfere with functioning 6. No current hazardous alcohol or drug use 7. No previous experience with mindfulness-based treatment (i.e., enrollment in MBSR or MBCT previously) 8. No current symptoms of mania indicative of a manic episode 9. No current cognitive impairment 10. No history of a formally diagnosed learning disability in reading, intellectual disability or other developmental disorder 11. No history of a neurologic illness affecting cognition 12. If on psychiatric medications, no change in medications for at least 4 weeks 13. If in psychotherapy, no change in therapy status for at least 4 weeks Exclusion Criteria: Exclusion criteria include: (a) presence of psychotic symptoms that interfere with one's ability to function as determined by the SCID-5 Psychotic Screening Module; (b) current hazardous alcohol or drug use as indicated by a score of \>10 for men and women on the AUDIT and the DUDIT for cannabis use, and \>6 for men and women on the DUDIT for all other drugs (everything but cannabis), (c) change in psychiatric drug prescription within 4 weeks; (d) started psychotherapy or other psychiatric treatment within the past 4 weeks; (e) current suicide ideation or behavior which requires urgent intervention due to safety concerns; (f) Previous enrollment in MBCT or MBSR; (g) symptoms of mild cognitive impairment as indicated by a score of \<26 on the MoCA; (h) formally diagnosed learning disability, intellectual disability, or other developmental disorder; (i) history of neurologic illness affecting cognition; (j) current symptoms indicative of a manic episode per the SCID-5 Mood Disorders Module.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Butler Hospital

    Providence, Rhode Island, 02906, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.