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Ukraine tests combining depression treatment with opioid addiction care

NCT ID NCT05646212

Disease control Sponsor: Ukrainian Institute on Public Health Policy Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Sep 16, 2026 · Updated 3 times

Summary

This study tests different ways to bring mental health treatment into methadone clinics in Ukraine. 1,350 patients from 12 clinics are taking part. Some clinics get extra training and financial rewards to help screen and treat depression. The goal is to see if these strategies improve how many patients get diagnosed, start treatment, and stay on antidepressants.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Selective serotonin reuptake inhibitors (SSRIs) and a telehealth training program (Project ECHO) plus financial incentives for clinics
What this could lead to
If successful, this could show a practical way to treat depression in people receiving opioid addiction treatment, improving their mental health and overall care.
What could go wrong
This is an implementation study, not a test of a new drug. The results may depend on local factors in Ukraine and may not apply elsewhere. The mental health benefits may be modest.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

1,350 people

The number who actually took part.

Started

Jul 2018

Finished

May 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * All patients receiving OAT at participating sites Exclusion Criteria: * Not willing to participate * Unable to sign informed consent

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Conditions

The condition(s) this trial relates to.

Depression depressive disorder opiate dependence

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Depression Opioid use disorder

Contacts and locations

Locations

  • Dnipropetrovsk narcological dispensary

    Pavlohrad, Dnipropetrovsk Oblast, 51405, Ukraine

  • Ivano-Frankivsk regional narcological dispensary

    Ivano-Frankivsk, Ivano-Frankivs'k, 01001, Ukraine

  • Kropyvnitsky regional narcological dispensary

    Kropyvnytskyi, Kirovohrad Oblast, 25000, Ukraine

  • Kryvyi Rig psycho-neurological dispensary

    Kryvyi Rih, Dnipropetrovsk Oblast, 01001, Ukraine

  • Kyiv city narcological clinic 'Sociotherapia'

    Kyiv, Kyiv Oblast, 01054, Ukraine

  • Mykolaiv City Hospital #5

    Mykolayiv, Mykolayiv, 54051, Ukraine

  • Mykolaiv regional narcological dispensary

    Mykolayiv, Mykolaiv Oblast, 54052, Ukraine

  • Ternopil regional narcological dispensary

    Ternopil, Ternopil Oblast, 04050, Ukraine

  • Vinnitsia regional narcological dispensary 'Sociotherapia'

    Vinnytsia, Vinnytsia Oblast, 01001, Ukraine

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