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Can quitting cannabis rewire the Brain's threat and reward responses?

NCT ID NCT07746440

Knowledge-focused Sponsor: Florida State University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 05, 2026 · Last updated Aug 06, 2026 · Updated 1 time

Summary

This study investigates how three weeks of cannabis abstinence influences brain responses to threat, reward, and cannabis cues in women with cannabis use disorder. Participants are randomly assigned to either continue using cannabis as usual or abstain for three weeks, with lab visits and phone surveys tracking changes. Using brain activity measures, the study aims to see if abstinence alters how the brain processes emotional and rewarding stimuli, and whether these changes differ between those who successfully abstain and those who relapse.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Contingency management (monetary reinforcement) for cannabis abstinence and lab visit attendance
What this could lead to
If successful, this could clarify how early abstinence affects brain responses to threat and reward, potentially guiding better treatments for cannabis use disorder.
What could go wrong
This is a small, early-stage study (30 participants) and measures brain activity, not real-world outcomes. Results may not generalize to all people with cannabis use disorder.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

30 people

The number who actually took part.

Started

Jan 2022

Finished

Jul 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 30 years

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * \>=5 cannabis use days per week on average over the past 3 months * Female * \>=6 past-year CUD symptoms (must include withdrawal and at least one criterion other than craving must be met within the past 3 months) * \>=20 days of cannabis use over the past 30 days * Positive urinalysis for THC * Cannabis is primary substance of abuse Exclusion Criteria: * Current pregnancy * History of psychotic, seizure, or cardiovascular disorder * Immediate plan to quit cannabis * Current treatment for cannabis use * Current daily psychotropic medication use * Lotion allergy * Positive urinalysis for any drug other than THC * CSRSS \>= 4 * Current moderate (4+ criteria) or severe (6+ criteria) substance use disorder (SUD) other than CUD or nicotine dependence * CBD use \>= 9 days

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Conditions

The condition(s) this trial relates to.

cannabis dependence

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cannabis use disorder, severe

Contacts and locations

Locations

  • The BRAINS Lab in the Department of Psychology at Florida State University

    Tallahassee, Florida, 32304, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.