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Hormones may hold key to cannabis addiction recovery

NCT ID NCT04964739

Knowledge-focused Sponsor: Medical University of South Carolina Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looked at how sex hormones and gender influence recovery from cannabis use disorder. 224 adults who wanted to cut down on cannabis received 8 weeks of counseling, including one-on-one goal setting and computerized therapy. They also provided daily saliva samples to track hormone levels. The goal was to see if hormones like progesterone affect the chance of achieving remission.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Cognitive Behavioral Therapy (CBT4CBT)
What this could lead to
If successful, this could help personalize cannabis use disorder treatments based on sex hormones.
What could go wrong
This is an observational study, not a treatment trial. Results may not lead to new therapies.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

224 people

The number who actually took part.

Started

Nov 2021

Finished

Oct 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Willingness to participate in a research study (otherwise, will be referred to appropriate clinical services if seeking clinical care). 2. Meet current (within last 30 days) DSM-5 criteria for cannabis use disorder. 3. Submit a positive urine cannabinoid test during screening. 4. Interested in treatment for cannabis use disorder. Exclusion Criteria: 1. Significant or acutely unstable medical or psychiatric problems (i.e., psychosis, mania) that would contraindicate research procedures, interfere with safety, compromise data integrity, or preclude consistent study participation. 2. The presence of any substance use disorder requiring a higher level of care. 3. Significant risk of homicide or suicide. 4. Pregnant, trying to become pregnant, or breastfeeding.

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Conditions

The condition(s) this trial relates to.

cannabis dependence follicular lymphoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cannabis use disorder, mild Cannabis use disorder, moderate Cannabis use disorder, severe

Contacts and locations

Locations

  • Medical University of South Carolina

    Charleston, South Carolina, 29425, United States

More trials for these conditions

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