Blood proteins may reveal clues about schizoaffective disorder
NCT ID NCT07447960
First seen Jun 27, 2026 · Last updated Sep 11, 2026 · Updated 2 times
Summary
This study will measure levels of two proteins, LRFN5 and OLFM4, in the blood of 120 people—some with schizoaffective disorder and some healthy. Researchers want to see if these proteins are linked to symptoms, overall function, and inflammation. The goal is to better understand the biology of this condition.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- What this could lead to
- If successful, this study could point toward new biomarkers for schizoaffective disorder, potentially aiding diagnosis or treatment monitoring.
- What could go wrong
- This is an early observational study with no intervention, so it cannot prove cause or lead directly to a treatment. Results may not apply to all patients.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
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110 people
The number who actually took part.
- Started
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Mar 2026
- Finished
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Jun 2026
- Lead sponsor
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A government agency
The lead sponsor is a government body.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
The study population will consist of adult participants aged 18-65 years. The schizoaffective disorder (SAD) group will include consecutive subjects diagnosed with SAD according to DSM-5-TR criteria who will be admitted to the psychiatry clinic of Elazığ Mental Health and Diseases Hospital (Turkey). The healthy control (HC) group will consist of individuals from the general population who will apply to the hospital medical board and will have no current or past psychiatric or significant medical disorders. All participants will provide informed consent prior to enrollment.
- Ages
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18 to 65 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
1. For Schizoaffective Disorder (SAD) Group: \*Inclusion Criteria: * Diagnosis of SAD according to DSM-5-TR * Acute manic episode * Medication-free for at least one month prior to admission * Age ≥ 18 years and \<65 years * Provided informed consent For Schizoaffective Disorder (SAD) Group: \*Exclusion Criteria: • Hypertension • Diabetes mellitus • Chronic kidney disease • Rheumatoid arthritis • Systemic lupus erythematosus • Cardiac illness • Severe neurological disorders • Immunological or systemic illness • Primary psychiatric disorders other than SAD * Alcohol/drug/substance use 2. For Healthy Control Group: \*Inclusion Criteria: • No psychiatric diagnosis • No systemic or immunological illness * Medication-free for at least one month * Age ≥ 18 years and \< 65 years * Provided informed consent For Healthy Control Group: \*Exclusion Criteria: * Hypertension * Diabetes mellitus * Chronic kidney disease * Rheumatoid arthritis * Systemic lupus erythematosus * Cardiac illness * Severe neurological disorders * Immunological or systemic illness * Having psychiatric disorders * Alcohol/drug/substance use
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Elazığ Mental Health and Diseases Hospital Psychiatry Clinic
Elâzığ, Elâzığ, 23200, Turkey (Türkiye)
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Other studies related to the condition(s) this trial covers.
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