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Can science unlock the secrets of the naturally lean?

NCT ID NCT03981432

Knowledge-focused Sponsor: University Hospital, Clermont-Ferrand Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 03, 2026 · Last updated Aug 04, 2026 · Updated 1 time

Summary

This study looks at what makes some women naturally lean without dieting or eating disorders. Researchers will compare eating habits, physical activity, body composition, and appetite responses in three groups: constitutionally lean women, normal-weight women, and women with anorexia nervosa. Participants will take part in lab sessions to measure how exercise and meals affect their appetite and food intake. The goal is to better understand the biological and behavioral profile of natural leanness.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Behavioral interventions: rest with fixed meal and rest with ad libitum meal
What this could lead to
If successful, this could help explain why some people stay naturally lean without eating disorders, potentially guiding healthier approaches to weight management.
What could go wrong
The study is small and observational in nature, so findings may not apply broadly. It does not test a treatment, so it won't directly change clinical care.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

34 people

The number who actually took part.

Started

Apr 2021

Finished

Nov 2023

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 35 years

Sex

Female participants only

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Common criteria to the three groups * Women * Aged 18 to 35 years old \-- Signed consent form * being registered in the national social security system * no contraindication to physical activity Criteria specific to constitutionally lean women * BMI ≤ 17.5 kg/m2 * Weight stable for the last three months * No dietary disorders * no sign of denutrition * absence of amenorrhea Criteria specific to women with anorexia nervosa * BMI ≤ 17.5 kg/m2 * Pure restrictive Anorxia nevrosa: no binge eating or vomiting episodes for the last thress months. * DSM V (2013) crietria Criteria specific to normal weight women * 20 kg/m2 ≤ BMI ≤ 25 kg/m2 * Weight stable for the last three months * No dietary disorders * no sign of denutrition * absence of amenorrhea Exclusion Criteria: * Pregnancy * Intensive physical activity level (aboce 3 sessions per week) * Impaired level of IGF-1, estradiol, T3free, cortisol and leptin (for normal weight and constitutionally lean women) * Previous surgical interventions that is considered as non-compatible with the study. * Diabetes * Medication that could interfer with the study. * cardiovascular disease or risks * Surgery within the last 3 months

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Conditions

The condition(s) this trial relates to.

anorexia nervosa Thinness

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Anorexia nervosa Constitutional leanness

Contacts and locations

Locations

  • Chu Clermont Ferrand

    Clermont-Ferrand, 63003, France

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