Brain zapping study targets odd sensations in OCD

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: OCD with abnormal sensory phenomena 1. Meet the diagnostic criteria for Obsessive-Compulsive Disorder according to Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition. 2. Aged 18-55 years. 3. Score ≥16 on the Yale-Brown Obsessive Compulsive Scale, indicating moderate to severe symptoms. 4. Score \>6 on the Sensory Phenomena Scale (SPS), indicating moderate to severe sensory phenomena. 5. Right-handed. 6. Either medication-free or on stable medication for at least 8 weeks. OCD without abnormal sensory phenomena 1. Meet the diagnostic criteria for Obsessive-Compulsive Disorder according to Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition. 2. Aged 18-55 years. 3. Score ≥16 on the Yale-Brown Obsessive Compulsive Scale. 4. Score ≤6 on the Sensory Phenomena Scale (SPS). 5. Right-handed. 6. Either medication-free or on stable medication for at least 8 weeks. Exclusion criteria 1. Meeting diagnostic criteria in Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition for psychiatric disorders other than OCD or obsessive-compulsive personality disorder. 2. OCD symptoms so severe that required assessments cannot be completed. 3. Presence of severe suicidal ideation or high suicide risk. 4. Pregnant women or women planning pregnancy in the near future. 5. History of epilepsy or any medical condition that may induce seizures or intracranial hypertension. 6. Contraindications to MRI, such as metallic implants. 7. Clinically significant medical illnesses or abnormal laboratory findings. 8. Inability to complete study procedures due to severe symptoms, low cognitive functioning, or poor cooperation. Healthy Controls Inclusion criteria 1. No current or past psychiatric disorders meeting diagnostic criteria in the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition. 2. Aged 18-55 years. 3. Right-handed. Exclusion criteria 1\. Pregnant women or women planning pregnancy in the near future. 2. History of epilepsy or any medical condition that may induce seizures or intracranial hypertension. 3\. Presence of severe suicidal ideation or high suicide risk. 4. Contraindications to MRI, such as metallic implants. 5. Clinically significant medical illnesses or abnormal laboratory findings. 6. Inability to complete study procedures due to severe symptoms, low cognitive functioning, or poor cooperation.