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Brain scans and Decision-Making tasks aim to uncover OCD's hidden markers

NCT ID NCT03313622

Knowledge-focused Sponsor: Baylor College of Medicine Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 30, 2026 · Last updated Jul 01, 2026 · Updated 1 time

Summary

This study looks for brain-based markers (biomarkers) of obsessive-compulsive disorder (OCD) in people with severe, hard-to-treat symptoms. Participants complete decision-making tasks and are exposed to personal OCD triggers while their brain activity is recorded with EEG and their facial reactions are filmed. The goal is to better understand the brain circuits involved in OCD, which could eventually lead to more personalized treatments.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could identify measurable brain signals linked to OCD symptoms, paving the way for more targeted treatments.
What could go wrong
This is a small, early-stage observational study focused on discovery, not treatment. It may not yield clear or generalizable biomarkers.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 20 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Mar 2027

An estimate. Start dates often move.

Expected to finish

Mar 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Potential subjects are patients diagnosed with OCD meeting the inclusion/exclusion criteria above.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Diagnosis of OCD * Non-pregnant if female * Minimum score of 16 on Y-BOCS * Ability to provide informed consent Exclusion Criteria: * Those not meeting inclusion criteria listed above * Lifetime diagnosis of psychotic disorders such as schizophrenia * Alcohol or substance abuse/dependence within 6 months, excluding nicotine * Deemed at high risk of suicidal behavior or impulsivity * Pregnant or plans to become pregnant in the next 24 months

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Conditions

The condition(s) this trial relates to.

obsessive-compulsive disorder obsessive-compulsive personality disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Obsessive - compulsive disorder OCD

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    3 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Baylor College of Medicine

    Houston, Texas, 77030, United States

  • Brown University

    Providence, Rhode Island, 02912, United States

  • University of Pittsburgh

    Pittsburgh, Pennsylvania, 15260, United States

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