OBSESSIVE-COMPULSIVE DISORDER

This early-stage study is testing whether psilocybin, the active compound in certain mushrooms, can help people with obsessive-compulsive disorder (OCD). Thirty adults with moderate to severe OCD will receive different doses of psilocybin mushrooms embedded in chocolate pieces du…

This study is testing a shorter, culturally adapted version of Cognitive Behaviour Therapy (CBT) to treat obsessive-compulsive disorder (OCD) in Pakistan. The goal is to see if this therapy, which is adjusted to fit local cultural beliefs and practices, is effective and acceptabl…

This study is testing a combination treatment for people with obsessive-compulsive disorder (OCD) that hasn't responded well to standard therapies. Participants receive a non-invasive brain stimulation treatment (rTMS) five days a week for six weeks, along with either a specific …

This study is testing whether adding a digital mindfulness program to regular medical care helps adults with emotional disorders like depression or anxiety recover faster and stay better over two years. Researchers will compare people who get the mindfulness program plus their us…

This study is testing whether a non-invasive brain stimulation technique, called transcranial magnetic stimulation (TMS), can make standard behavioral therapy more effective for young people with OCD. Researchers will compare two different types of 'real' TMS against a 'fake' (sh…

This study is testing whether psilocybin, the active compound in 'magic mushrooms,' given with therapy can help people with severe obsessive-compulsive disorder (OCD) that hasn't improved with standard treatments. Ten participants will receive two guided psilocybin sessions to se…

This study is testing whether an intensive, 5-day course of magnetic brain stimulation can reduce symptoms of obsessive-compulsive disorder (OCD) in adults who haven't gotten enough relief from standard medications. Participants receive six brief stimulation sessions per day for …

This study is testing whether MDMA (commonly known as ecstasy) or methamphetamine, when combined with talk therapy, can help reduce symptoms of obsessive-compulsive disorder (OCD). It will involve 40 adults with moderate to severe OCD who haven't gotten enough help from standard …

This study is testing whether guided therapy sessions using the psychedelic compound psilocybin can help people with severe obsessive-compulsive disorder (OCD) who haven't been helped by standard treatments. It will involve 15 participants who will receive talk therapy along with…

This early-stage study is testing whether psilocybin, the active compound in psychedelic mushrooms, can help control symptoms of obsessive-compulsive disorder (OCD). Researchers at Johns Hopkins University will give 30 adults with treatment-resistant OCD two doses of psilocybin a…

This study is testing whether a non-invasive brain stimulation technique called rTMS can help reduce symptoms of obsessive-compulsive disorder (OCD). It involves 136 adults with OCD who haven't gotten enough relief from at least two different medications. Researchers will use mag…

This study is testing a new, two-step brain surgery for people with severe obsessive-compulsive disorder (OCD) that hasn't improved with standard medications or therapy. First, doctors use temporary brain mapping to find the best spot for stimulation. Then, they implant a permane…

This study is testing whether an intravenous medication called RR-HNK can safely reduce symptoms of obsessive-compulsive disorder (OCD). It will involve about 45 adults whose OCD hasn't improved enough with standard treatments like therapy or other medications. Participants will …

This study is testing whether virtual reality exposure therapy can help people with obsessive-compulsive disorder (OCD). Thirty outpatients in the Czech Republic will use VR headsets to face simulated triggers in a virtual house and garden. Researchers will compare symptoms befor…

This study is testing whether a single session combining a non-invasive brain stimulation technique (rTMS) with training in emotion regulation skills can help people who struggle to calm down when upset. Researchers want to see if this combined approach changes brain activity and…

This study is testing whether adding virtual reality exposure therapy to standard cognitive behavioral therapy (CBT) helps people with obsessive-compulsive disorder (OCD). Researchers are comparing three groups: one gets standard CBT plus VR exposure, another gets standard CBT pl…

This Stanford study is testing whether a gentle ear stimulation technique can help people with obsessive-compulsive disorders better recognize their intrusive thoughts as symptoms of illness. Researchers are enrolling 16 adults with conditions like OCD, body dysmorphic disorder, …

This is an observational study aiming to understand how brain development is linked to impulsive and compulsive behaviors. Researchers will recruit 1,100 people aged 6 to 80, including twins, to track brain changes over time using interviews, surveys, and MRI scans. The goal is t…

This study aims to collect detailed information from 4,500 patients before and after various brain and spine surgeries. The goal is to identify which factors best predict a patient's recovery and quality of life after their operation. By standardizing how outcomes are measured ac…

This study aims to identify biological markers that predict how well different brain stimulation and medication treatments work for severe depression and obsessive-compulsive disorder (OCD). Researchers will collect data from 1,000 patients receiving treatments like electroconvul…

This study aims to understand how stimulating different parts of the brain with magnetic pulses affects symptoms of several mental health conditions. Researchers will enroll 180 adults with depression, anxiety, OCD, or schizophrenia to receive non-invasive brain stimulation at ra…

This study aims to understand exactly how exposure therapy helps people with obsessive-compulsive disorder (OCD). Researchers will monitor 400 adults receiving this therapy, tracking their symptoms, body responses, and session details. By using machine learning, they hope to iden…

This study aims to better understand the brain activity and thinking patterns behind obsessive-compulsive disorder (OCD). Researchers will use brain scans (EEG) and computer models to compare 50 adults with OCD to 50 healthy adults. The goal is to gather detailed information that…

This study aims to find out if a person's reaction to a safe, brief carbon dioxide (CO2) breathing test can predict whether they will not respond to a common and effective talk therapy called exposure therapy. Researchers will give the test to 600 adults with conditions like anxi…