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Can zapping two brain areas beat OCD?

NCT ID NCT04958096

Disease control Sponsor: Andrew Moses Lee, MD, PhD Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study is testing whether adding stimulation to the front part of the brain can improve standard deep brain stimulation (DBS) for severe obsessive-compulsive disorder (OCD). Fifteen adults with OCD that hasn't improved with other treatments will get DBS plus an extra set of electrodes in the prefrontal or cingulate cortex. Researchers will track brain signals and OCD symptoms for up to two years to see if the extra stimulation helps.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
deep brain stimulation and cortical stimulation
What this could lead to
If successful, this could point toward a more effective brain stimulation treatment for severe OCD that doesn't respond to other therapies.
What could go wrong
This is a very early, small study with only 15 people. It's testing a new combination of brain stimulation, so it may not work better than standard DBS, and there are surgical risks from implanting extra electrodes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 15 people

The number the study aims to enrol. It can still change while the study runs.

Started

Aug 2021

Expected to finish

Aug 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

22 to 75 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Ability to give informed consent for the study * Age 22-75 * Clinical diagnosis of OCD * Documented duration of OCD of at least 5 years * OCD rated as severe or extreme illness (YBOCs ≥ 28) * Has failed to improve following treatment with at least two selective serotonin reuptake inhibitors (SSRIs), clomipramine, and augmentation with antipsychotics * Has not responded to adequate trials of cognitive behavior therapy (exposure and response prevention) * Has not responded adequately to TMS treatment for OCD if it is reasonably available to the patient Exclusion Criteria: * Has hoarding as a primary subclassification of OCD according to DSM-4 * Has another severe psychiatric disorder (personality disorder, psychotic/bipolar disorder, etc) or substance abuse issues * Is pregnant * Has an abnormal MRI assessed by the team or has a neurological condition requiring an MRI in the future * Has a cognitive disorder or dementia * Is at imminent risk for suicide based upon Suicide Severity Rating Scale (SSRS) or has ever attempted suicide * Inability to comply with study follow-up visits * Major comorbidity increasing the risk of surgery (prior stroke, severe hypertension, severe diabetes, or need for chronic anticoagulation other than aspirin) * Allergies or known hypersensitivity to materials in the Activa systems (i.e. titanium, polyurethane, silicone, polyethermide, stainless steel). * Previous cranial ablative or deep brain stimulation surgery. * Patients may be excluded from enrollment due to a condition that, in the judgement of the PI, significantly increases risk or reduces significantly the likelihood of benefit from DBS.

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Conditions

The condition(s) this trial relates to.

Compulsive Behavior obsessive-compulsive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Obsessive compulsive disorder

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The study's own enquiry address

    This study publishes an address for enquiries. See it below .

  2. The places running it

    1 site. The list below names each one and where it is.

  3. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  4. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Study contacts

  • Contact

    Email: •••••@•••••

  • Contact

    Email: •••••@•••••

Locations

  • UCSF Nancy Friend Pritzker Psychiatry Building

    RECRUITING

    San Francisco, California, 94107, United States

    Contact Email: •••••@•••••

    Contact Email: •••••@•••••

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