NEUROPATHIC PAIN

This study tests a device called the Tulavi Allay™ Nerve Cap, placed on cut nerve endings during finger amputation surgery, to prevent painful neuromas and chronic pain. About 20 adults who recently lost a finger due to injury will be enrolled. The goal is to see if the cap reduc…

This study looks at whether a spinal cord stimulator can reduce pain and improve blood vessel health in people with type 2 diabetes who have nerve pain in their legs. About 25 adults with diabetes for over a year and poor circulation will get the device. Researchers will check pa…

This study aims to translate and test a questionnaire called PainPREDICT for Thai-speaking adults with type 1 or type 2 diabetes to screen for painful diabetic neuropathy, a common complication causing nerve pain. Researchers will also develop a mobile app version and check how a…

This study tests a new way to stimulate the brain (called Burst-DBS) to see if it can better reduce chronic pain after a stroke or from nerve damage in the face. About 20 adults will try both the new and standard stimulation patterns to compare which works better. The goal is to …

This study tests a safe, home-use brain stimulation device (tDCS) for people with long-term pain who only got short relief from hospital treatments. About 70 adults will use the device 5 days a week for 20 minutes, for 3 months. Half get real stimulation, half get a fake version,…

This study tests whether playing a virtual reality walking game can help reduce nerve pain in adults with chronic spinal cord injury. Researchers will enroll 250 people who have had a spinal cord injury for at least a year and experience daily pain of 4 or higher on a 10-point sc…

This study looks at whether a closed-loop spinal cord stimulator can reduce pain and improve quality of life in people with nerve damage from chemotherapy. About 20 adults with persistent pain in their arms or legs will receive the device, which automatically adjusts stimulation …

This study tests whether training the leg reflexes can reduce nerve pain in people with spinal cord injury. Researchers will enroll 15 adults who have had a spinal cord injury for at least a year and have nerve pain in their lower leg. Participants will attend about 50 sessions o…

This study in Ukraine compares two minimally invasive procedures—cryoablation (freezing) and radiofrequency ablation (heating)—to treat nerve pain caused by neuromas from combat injuries. Fifty adults with moderate to severe pain will be randomly assigned to one treatment. The go…

This study compares a newer injection method (transgrade) with a standard one (interlaminar) for people with long-term leg and back pain. Researchers want to see which approach provides better pain relief three months after treatment. The study involves 80 adults who have not fou…

This study tests whether a non-invasive brain stimulation technique called deep rTMS can reduce chronic pain in people with nerve damage or fibromyalgia. About 70 adults with daily pain for at least 6 months will receive either real or sham (fake) treatment over 3 months. The goa…

This study tests whether a non-invasive magnetic brain stimulation technique (rTMS) can reduce stubborn nerve pain in people with spinal cord injuries. Researchers will compare two brain areas—the motor cortex and the anterior cingulate cortex—to see which provides better pain re…

This early-stage trial tests a new drug called EC5026 for nerve pain caused by spinal cord injury. About 36 adults with this type of pain will take either the drug or a placebo daily for 14 days. The main goal is to check if the drug is safe and tolerable, while also seeing if it…

This study tests whether combining spinal cord stimulation with a rehabilitation program can reduce long-term nerve pain in the legs and improve daily function. Ten adults aged 18-60 with nerve pain from back problems or injury will receive both treatments together. The goal is t…

This study tests whether a non-invasive treatment called repetitive transcranial magnetic stimulation (rTMS) can reduce nerve pain in people with spinal cord injury. About 63 adults with spinal cord injury and chronic neuropathic pain will receive either real rTMS or a sham (fake…

This study looks at whether a 12-week progressive resistance exercise program can help reduce chronic pain in people with multiple sclerosis. Researchers will compare a group that exercises to a waitlist group that continues usual care. The goal is to find a drug-free way to mana…

This study tests two minimally invasive procedures—cryoablation (freezing) and radiofrequency ablation (heating)—to control severe chest pain after combat injuries. About 50 adults in Ukraine will be randomly assigned to one treatment, and researchers will measure pain levels, op…

This study tests whether taking two dietary supplements (PEA and Scutellaria) along with a structured exercise program can reduce nerve pain and damage caused by chemotherapy. About 40 adults who completed chemo in the last 6 months and have moderate to severe nerve pain will be …

This study tests whether a non-invasive brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) can reduce nerve pain in people with spinal cord injury. Researchers will apply high-frequency rTMS to a brain area involved in pain processing and measu…

This study looks at three different hand therapies—mirror therapy, brain stimulation, and robotic hand training—added to standard rehab for stroke patients. The goal is to see which one works best for improving arm movement, reducing pain, and boosting quality of life. About 120 …

This study tests whether giving calcitonin soon after a spinal cord injury can lower the chance or severity of nerve pain that often follows. Researchers will enroll 126 adults with recent spinal cord injuries and track their pain levels for up to a year. The goal is to see if ea…

This study tests whether cannabis compounds (THC, CBD, or both) can reduce chronic nerve pain in Veterans. About 320 Veterans with neuropathic pain will receive either a cannabis derivative or a placebo for 6 weeks. The goal is to see if these compounds provide better pain relief…

This study tests whether playing a virtual reality walking game can reduce nerve pain in adults with incomplete spinal cord injury. Researchers will enroll 48 people who have had daily pain of at least 4 out of 10 for three months or more. Participants will use a VR headset to pl…

This study tests whether eye drops made from cord plasma can relieve pain caused by damaged nerves in the eye. Researchers will enroll 20 adults with persistent eye pain and nerve abnormalities. The drops aim to reduce pain and inflammation, and participants will report their pai…

This study compares two treatments for long-term nerve pain after shingles (postherpetic neuralgia). Researchers will give 50 adults either a nerve block injection or a radiofrequency treatment to see which reduces pain more. The goal is to find a better way to ease this stubborn…

This study tests whether a capsaicin 8% skin patch (made from chili pepper extract) can reduce chronic nerve pain in teenagers aged 12 to 17 who have had pain for more than 3 months after surgery or an injury. Half of the 46 participants will get the real patch, and the other hal…

This study is testing a self-hypnosis program that runs on a virtual reality headset to help people with HIV manage chronic pain. The goal is to see if the software is safe, easy to use, and provides some pain relief. Twenty-five adults with HIV and stable pain will use the VR pr…

This study compares three different NSAID painkillers (diclofenac, meloxicam, indomethacin) combined with home exercises for frozen shoulder. 120 adults with shoulder pain and stiffness will be randomly assigned to one of the drugs. The goal is to see which drug works best and wh…

This study looks at whether a surgery called RPNI can reduce nerve pain and improve daily life for people who have had a leg amputated. Twenty adults with painful nerve growths (neuromas) will have the surgery and be followed for two years. The goal is to see if the surgery makes…

This study tests whether a high-dose capsaicin patch (the stuff that makes chili peppers hot) can relieve chronic tailbone pain. About 188 adults with pain lasting over 3 months will receive either the active patch or a low-dose placebo patch. The main goal is to see if more peop…

This study is testing whether combining a non-invasive brain stimulation technique (rTMS) with virtual reality mirror therapy can better relieve chronic nerve pain that hasn't responded to standard drugs. Researchers will enroll 64 adults with moderate to severe nerve pain lastin…

This study tests whether combining body illusions (tricks that change how you perceive your body) with mild brain stimulation can reduce nerve pain and improve sensation in people with spinal cord injury. Researchers will enroll 30 adults with long-lasting neuropathic pain. The g…

This study looks at whether adding ultrasound-guided shoulder injections to a home exercise program can improve pain, movement, and daily function in people with chronic frozen shoulder. About 68 adults with shoulder pain lasting at least 3 months will receive either one type of …

This study compares two types of nerve blocks to prevent chronic pain after video-assisted lung surgery. Forty adults scheduled for elective lung surgery will be randomly assigned to receive either an ultrasound-guided nerve block or a surgeon-given block. The goal is to see whic…

This study is testing a new tool called CANoPy that predicts the risk of chronic nerve pain in cancer patients. Researchers will follow 625 adults with breast, gynecological, colorectal, or lung cancer who are about to start treatment. The goal is to give doctors a simple way to …

This study is for adults with shoulder pain lasting at least 3 months. Researchers want to understand how nerve-related pain and a condition called central sensitization (where the nervous system becomes overly sensitive) affect each other. Participants will fill out questionnair…

This study uses a smartphone app called SOMA to track daily mood, pain, and activity in 800 people with acute or chronic pain over four months. The goal is to see if daily changes in these factors can predict whether pain becomes long-term or flares up. A smaller group will also …

This study looks at how spinal cord stimulation (SCS) helps people with long-term nerve pain. Researchers will measure certain molecules in the blood and spinal fluid of 30 adults before and after SCS to see which ones change. The goal is to learn how SCS works and find ways to m…

This study tests whether taking ginger supplements for 8 weeks can help researchers understand how the gut and brain interact in people with chronic sciatica (nerve pain in the leg). Eighty adults with sciatica will receive either ginger or a placebo. The goal is not to cure the …

This study aims to find out how often nerve pain (neuropathic pain) occurs in people aged 80 and older, and how it relates to their overall health. Researchers will assess 450 participants using questionnaires and physical exams. The goal is to better understand pain in this age …

This study looks at how nerve pain (neuropathic pain) affects the ability to care for oneself and overall quality of life in people with type 2 diabetes. Researchers will measure pain levels and quality of life in 128 adults using standard questionnaires. No new treatments are te…

This study looks at how spinal cord stimulation (SCS) helps people with long-term nerve pain in the back or legs. Researchers will use brain scans to understand why some types of SCS work better than others. The goal is to find out which patients are most likely to benefit and im…

This study is collecting information from 4,500 people who have had brain surgery for conditions like aneurysms, tumors, or epilepsy. The goal is to find out what factors help predict recovery, such as thinking skills and emotional health. By standardizing how outcomes are measur…

This study looks at how a simple pain questionnaire (PainDETECT) relates to where people feel pain and their diagnosis. Researchers will review medical records of 150 adults with muscle or joint pain. The goal is to better understand nerve-related pain in these conditions, but no…

This study looks at nerve pain in children and teens who had a limb removed before age 15-16. Researchers want to find out how common phantom or stump pain is and how it affects daily life and well-being. About 50 participants will fill out questionnaires during regular check-ups…