NEUROPATHIC PAIN

This study tests whether a gentle brain stimulation technique called tDCS, combined with standard rehabilitation, can prevent the development of chronic pain after a stroke. Researchers will enroll 60 stroke survivors who are at high risk for pain and give half of them real stimu…

This early-stage study tests whether a new drug called ASCT-83 is safe for people with nerve pain. It involves 72 healthy adults who will receive either the drug or a placebo. The study checks for side effects and how the drug moves through the body. Results will help design futu…

This study explores a new way to treat cervical radiculopathy (nerve pain in the neck and arm) by gently moving the nerves in the opposite, pain-free arm. It is for people who cannot tolerate direct treatment on their painful side due to sensitivity or fear. Forty adults will rec…

This study tests a non-invasive device called Scrambler Therapy to relieve nerve pain in children with cancer that has spread to the bones. About 70 children will receive the treatment, and researchers will measure changes in pain intensity and medication use. The goal is to impr…

This pilot study tests whether a small device that gently stimulates a nerve in the ear can safely reduce nerve pain in people with spinal cord injury. Thirty-two adults will use the device at home for 30 days, and researchers will measure pain levels, inflammation, and quality o…

This early-phase study tests whether a diabetes drug called glibenclamide (glyburide) can safely reduce nerve pain in people with multiple sclerosis. Ten adults with MS and moderate-to-severe nerve pain will take the oral extended-release drug. Researchers will measure safety, dr…

This study tests whether aromatherapy foot massage can reduce nerve pain in people with type 2 diabetes. About 78 adults will do a 10-minute foot massage three times a week for 4 weeks. Researchers will compare the effects of scented oil versus plain oil to see if the aromatherap…

This study tests a new way to treat nerve pain after spinal cord injury. Ten people will try a combination of virtual reality walking, muscle vibration, and mild brain stimulation over 10 sessions. The goal is to see if this approach lowers pain and improves daily life. Researche…

This study tests a special gel applied to the skin to see if it can quickly reduce pain from shingles. About 30 adults with shingles pain will get one application of the gel. The main goal is to see if pain drops within 2 minutes and stays lower for 24 hours.

This study tests a spinal cord stimulator for people with chronic nerve pain caused by chemotherapy. About 68 adults who have had pain for at least a year and haven't found relief from standard treatments will receive an implanted device. The trial will compare periods when the d…

This study tests an injectable supplement containing ATP and B vitamins to see if it reduces nerve pain, numbness, and tingling in people with diabetic neuropathy. About 200 adults with diabetes and nerve symptoms will receive either the study supplement or an active comparator f…

This study tests a wearable ultrasound device that aims to reduce nerve pain without surgery or medication. The device is placed on the skin over the painful area and delivers gentle ultrasound pulses. About 90 adults with chronic nerve pain will attend one visit to try the devic…

This study tests whether performing pain-relief procedures, like nerve blocks, at home is safe and effective. It includes 100 adults with chronic, cancer, or nerve pain who are already receiving home hospital care. The goal is to reduce pain and the need for strong painkillers wh…

This study tests if extracorporeal shockwave therapy (ESWT) can reduce pain and improve walking in people with both peripheral neuropathy and plantar fasciitis. About 114 adults with nerve damage and chronic heel pain will receive ESWT. The goal is to see if this non-invasive tre…

This early study tests a brain stimulation technique for people with long-term nerve pain that hasn't responded to other treatments. About 20 adults will receive a surgically placed device to stimulate specific brain networks. The main goal is to see if the procedure is feasible …

This study creates a large international registry to collect real-world data on spinal cord stimulation and other neuromodulation therapies for neuropathic pain. Researchers will track patient outcomes, device safety, and effectiveness across clinics in multiple countries. The go…

This study looks at 150 adults with burn scars from explosions or drone attacks to see if early ultrasound images can predict which scars will stay painful for 3 to 6 months. Researchers will measure scar thickness, blood flow, and nerve involvement using ultrasound, then check p…

This study looks at 180 adults getting a heart device (like a pacemaker) for the first time. Researchers will track their pain and quality of life for a year. They will use this data to build an AI system that can predict who is at risk for long-term pain, so doctors can help pre…

This study looks at spinal cord swelling after a procedure called cordotomy, which is used to treat severe cancer pain. Researchers will use MRI scans to measure swelling and compare it to patients' pain levels and other symptoms. The goal is to better understand how these change…