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Zapping pain without drugs: brain stimulation put to the test for nerve pain

NCT ID NCT07735975

Symptom relief Sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 30, 2026 · Last updated Jul 31, 2026 · Updated 1 time

Summary

This trial tests whether a non-invasive brain stimulation technique called temporal interference stimulation (tTIS) can reduce neuropathic pain—pain caused by nerve damage. Researchers will monitor changes in pain levels and brain plasticity in 60 adults with peripheral neuropathic pain. The goal is to see if tTIS offers a new, drug-free option for managing this often-chronic condition.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
a non-invasive brain stimulation technique called temporal interference stimulation (tTIS)
What this could lead to
If it works, this could offer a new, drug-free way to manage chronic neuropathic pain.
What could go wrong
This is an early-stage trial with only 60 participants, so results may not apply to everyone. The technique is still experimental, and its long-term effects are unknown.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 60 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Aug 2026

An estimate. Start dates often move.

Expected to finish

Jan 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * IASP diagnosis of peripheral neuropathic pain; * At least one month after the onset of pain; * At least moderate pain intensity (≥ 3 assessed by VAS or NRS); * 18 years or older; * Stable medical treatment from 2 weeks before allocation to the end of the trial; * Willing to receive TIS treatment and capable of fulfilling clinical assessments. Exclusion Criteria: * Contradictions to TIS treatment, such as metal implants or seizure; * Serious psychiatric disorder (Hamilton Depression Rating Scale score ≥ 35 or Hamilton Anxiety Rating Scale score ≥ 29); * Aphasia or cognitive disorders (Mini mental state examination ≤ 24); * Severe clinical disorders caused by tumor or other conditions; * Severe cardiopulmonary dysfunction or extreme weakness; * History of substance abuse (alcohol, drugs).

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Conditions

The condition(s) this trial relates to.

neuralgia twin to twin transfusion syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Neuropathic pain TTIS

How to take part

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  1. The official record

    The full official record for this study. This one lists no contact details, but it is the first place any would appear.

    Open the record ↗

  2. A doctor treating you

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