Second Affiliated Hospital, School Of Medicine, Zhejiang University

This study tests whether adding a chemotherapy drug (thiotepa) directly into the spinal fluid can prevent the spread of glioblastoma, a fast-growing brain cancer, in patients at high risk. About 38 adults with newly diagnosed glioblastoma will receive the standard treatment plus …

This study looks at whether a drug called guselkumab can help people with moderate to severe Crohn's disease who did not get better with or could not tolerate another drug called ustekinumab. About 60 adults will take guselkumab for a year, and researchers will check if their sym…

This study tests a new combination of drugs given before surgery for people with advanced head and neck cancer. The goal is to see if the combo can shrink tumors enough to make surgery easier or more effective. About 76 adults with stage III-IV cancer will receive the treatment a…

This study follows 120 people with early Alzheimer's disease or mild cognitive impairment who are taking lecanemab, a new FDA-approved drug that targets harmful protein clumps in the brain. Researchers will track changes in memory, daily function, and brain scans over 18 months. …

This study tests whether phycocyanin, a natural protein from spirulina, can improve liver health in adults with liver fibrosis or cirrhosis. Ten participants will take either phycocyanin or a placebo daily for at least 4 weeks. Researchers will measure changes in liver stiffness …

This study tests a modified chemotherapy regimen (TEAM) followed by a stem cell transplant for lymphoma patients at high risk of the cancer spreading to the brain or spinal cord. The goal is to see if this approach can help patients stay cancer-free longer with fewer side effects…

This study compares a newer, less invasive procedure called transcatheter aortic valve replacement (TAVR) to traditional open-heart surgery in 1,250 people aged 65 and older with severe aortic regurgitation (a leaky heart valve). The goal is to see if TAVR is as safe and effectiv…

This study tests whether adding the experimental drug AK104 to standard chemotherapy and either cetuximab or bevacizumab can shrink tumors in people with a specific type of advanced colorectal cancer (MSS type) that has spread. About 40 adults aged 18 to 75 whose cancer got worse…

This study looks at two medicines, guselkumab and ustekinumab, to see which works better for people with Crohn's disease that causes narrowing of the intestines. About 100 adults with moderate-to-severe Crohn's and symptoms of blockage will be followed for a year. Doctors will ch…

This study tests whether ciprofol, a newer anesthetic, can prevent dangerously low blood pressure during surgery better than standard drugs. It involves 140 older adults (65+) who take long-term blood pressure medication and are having abdominal surgery lasting over 2 hours. The …

This study looks at whether giving iron supplements to anemic patients before major heart surgery can improve their long-term quality of life, sleep, and fatigue. About 400 adults with iron-deficiency anemia scheduled for heart surgery will be randomly assigned to receive iron or…

This early-phase study tests a new treatment made from cord blood cells that are engineered to find and attack cancer cells in people with B-cell non-Hodgkin lymphoma that has not responded to standard therapy. About 24 adults aged 18 to 75 will receive these special immune cells…

This study tests a new treatment for people who suddenly lose vision because a small artery in the eye is blocked. The treatment combines a tiny needle injection into the eye's blood vessel with a standard surgery to remove the gel inside the eye. The goal is to see if this appro…

This study tests a new combination of liposomal irinotecan, fluorouracil, and either bevacizumab or cetuximab as a second treatment for people with advanced colorectal cancer that has spread. The goal is to see if this approach can shrink tumors and delay cancer growth. About 100…

This study is testing a new treatment for people whose multiple myeloma has come back or stopped responding to standard therapies. The treatment uses specially engineered immune cells (CAR-T cells) that target two proteins, CD19 and BCMA, on myeloma cells to attack them. The stud…

This study is testing whether adding leucine, a common amino acid found in food, to standard chemotherapy and radiation can help eliminate more cancer cells in people with locally advanced rectal cancer. About 33 adults will receive leucine alongside their usual treatment before …

This study looks at whether giving radiation therapy after surgery can delay the return of tongue cancer in patients with early-stage disease who have certain risk factors. About 190 adults aged 18 to 70 will be randomly assigned to receive either radiation or just regular check-…

This study tests a new immunotherapy drug (iparomlimab and tuvonralimab) combined with radiation and chemotherapy for people with advanced head and neck cancer that hasn't spread. The goal is to see if this combination can keep the cancer from coming back for at least one year. A…

This early-stage trial is testing a new treatment for people with advanced colorectal cancer that has spread to the lining of the abdomen (peritoneal metastases). Participants first have surgery to remove as much tumor as possible, then receive an infusion of their own immune cel…

This study compares high-dose and extended-interval guselkumab against the standard dose in 400 Chinese adults with moderate to severe plaque psoriasis. The goal is to see which dosing schedule works best to clear skin and stay safe over 86 weeks. Participants must have had psori…

This early-stage study tests a new treatment made from umbilical cord blood cells that are engineered to recognize and attack T-cell lymphoma. It is for people whose cancer has returned or not responded to at least one prior therapy. The main goals are to check safety and find th…

This study tests whether a drug called leucogen can prevent severe neutropenia (dangerously low white blood cell counts) in women with early-stage hormone receptor-positive, HER2-negative breast cancer who are receiving ribociclib plus hormone therapy. About 94 participants will …

This study tests whether fexofenadine hydrochloride, a common allergy medication, can improve long-term outcomes for people who have recently had a heart attack. About 2,800 participants will receive either the drug or a placebo and be followed for 24 months. The goal is to see i…

This early-stage trial tests a new cell therapy (UX-GIP001) for adults with drug-resistant mesial temporal lobe epilepsy. Six participants will receive an injection of special brain cells designed to calm overactive nerve signals. The main goal is to check safety and see if it re…

This early-phase trial tests a new treatment called EPC-003, a type of CAR-T cell therapy, in 14 people with glioblastoma that has come back or not responded to standard care. The therapy is given directly into the fluid around the brain through a small device. The main goal is t…

This study tests a drug called vebreltinib for people with advanced clear cell sarcoma, a rare cancer. About 30 participants will take the pill twice a day to see if it shrinks tumors or stops the cancer from growing. The goal is to control the disease, not cure it, and researche…

This study tests a new treatment using specially engineered immune cells (CAR-NK) from cord blood for people with severe autoimmune diseases like lupus, scleroderma, and vasculitis that haven't improved with standard treatments. The goal is to see if a single infusion can safely …

This study compares two approaches for people with chronic coronary syndrome (narrowed heart arteries). One group gets a special CT scan to guide procedures like stents, while the other gets only medications. The goal is to see which strategy better prevents heart attacks, death,…

This study tests whether adding a PCSK9 inhibitor (a powerful cholesterol-lowering drug) to standard treatment can prevent major heart problems like heart attacks, strokes, or death in people with high-risk coronary plaques seen on CT scans. About 3,600 adults with at least one s…

This early-stage study tests a new treatment for B-cell lymphoma that has come back or not responded to other therapies. The treatment uses a specially designed virus to deliver CAR-T/M cells directly into the body to attack cancer cells. About 48 adults aged 18 to 75 will take p…

This study tests special lens implants that correct both cataracts and presbyopia (age-related blurry near vision) in people with unusual eye shapes. About 320 adults with conditions like lens dislocation or inflammation will get these lenses during cataract surgery. Doctors will…

This study tests a small device called iStent that is placed in the eye during cataract surgery to help drain fluid and lower pressure in people with open-angle glaucoma. About 60 adults will take part to see if the implant safely reduces eye pressure. The goal is to better contr…

This study tests whether adding three immunotherapy drugs to a standard liver cancer procedure (TACE) can shrink tumors better than TACE alone. About 36 adults with advanced liver cancer will be randomly assigned to one of three treatment groups. The goal is to find a safer, more…

This study tests a new drug called envafolimab, given as a shot under the skin, combined with standard chemotherapy (doxorubicin and ifosfamide) for people with advanced soft tissue sarcoma who haven't had treatment before. The goal is to see if the combo works better than chemo …

This early-phase trial tests a universal mRNA vaccine designed to target common genetic mutations found in high-grade gliomas, a type of aggressive brain cancer. The study involves 10 participants with recurrent or progressive disease who have specific tumor mutations. The vaccin…

This study is for people with moderate-to-severe Crohn's disease who have a narrowed intestine causing blockages. Researchers are testing a treatment plan centered on the drug ustekinumab to see if it can improve symptoms, reduce inflammation, and help patients avoid surgery or t…

This study tests a new type of radiation therapy (SFRT) given before surgery for people with large soft tissue sarcomas (at least 5 cm) in the arm, leg, or trunk. The goal is to see if this approach can improve the chance of being cancer-free one year after treatment. About 22 ad…

This early-phase trial tests a personalized approach to deep brain stimulation (DBS) for people with treatment-resistant depression. Researchers use brain scans and recordings to find the best spot and settings for each patient's implant. The goal is to see if this tailored DBS c…

This study compares two maintenance treatments for people with high-risk multiple myeloma after initial therapy. One group gets ixazomib plus a lower dose of lenalidomide, the other gets ixazomib alone. The goal is to see which approach better delays the cancer's return. About 10…

This trial tests a new device called VISOR for removing kidney stones in 20 adults aged 18-80 with stones 1-3 cm. The tool breaks stones and suctions out fragments while keeping kidney pressure safe. The main goal is to see if at least 9 out of 10 people are stone-free within 24 …

This study tests whether a device that sends mild electrical pulses to the spinal cord can help people with chronic spinal cord injury regain movement and feeling. Ten participants with injuries between the T11 and L3 vertebrae will have the device surgically implanted and then u…

This study tests whether adding the immunotherapy drug pucotenlimab to standard chemoradiation can help more people with locally advanced rectal cancer achieve a complete response before surgery. About 68 adults aged 18-75 will receive the combination, and researchers will check …

This study tests a personalized approach for people with HER2-positive early breast cancer. After initial treatment, those who don't respond well will switch to a stronger drug combination. The goal is to improve the chance of eliminating all cancer before surgery, while reducing…

This study tests whether a robot guided by artificial intelligence can help surgeons perform minimally invasive brain surgery for people with moderate bleeding in the basal ganglia (a deep brain area). The goal is to improve recovery and reduce long-term disability after a stroke…

This study tests whether using AI-guided robotic tools to remove blood clots from the brain can help people recover better after a hemorrhagic stroke. About 1,000 adults with different types of bleeding strokes will be randomly assigned to either the new robotic surgery or standa…

This study tests whether a diet that removes refined and intolerant foods can help people with Crohn's disease stay in remission after bowel surgery. Researchers will track quality of life and nutrition in 35 participants. The goal is to develop a practical dietary plan for Chine…

This study tests whether a drug-coated balloon works as well as a drug-coated stent in people having a severe heart attack (STEMI). About 1,244 adults will be randomly assigned to one of the two treatments during emergency artery-opening procedures. The goal is to see which appro…

This study is for people with triple-negative breast cancer whose tumors did not shrink after standard chemotherapy. The goal is to see if adding a short course of high-precision radiation followed by an immunotherapy drug (toripalimab) and more chemo can make the cancer disappea…

This study tests whether a surgically implanted device that sends electrical pulses to the spinal cord, combined with daily rehab, can improve walking in people with chronic spinal cord injury. Twelve participants with partial paralysis will be followed for a year to check safety…

This study tests whether combining two drugs—guselkumab and a JAK inhibitor—can help people with inflammatory bowel disease (IBD) that hasn't improved with other treatments. About 80 participants with moderate to severe IBD will receive the combination and be followed for up to 5…

This study tests a new way to size replacement heart valves for people with a specific type of bicuspid aortic valve disease. About 206 older adults with severe narrowing of the valve will be randomly assigned to either the new downsizing method or the standard method. The goal i…

This early-stage study is testing a new treatment called CAR-T cells that are designed to find and attack cancer cells carrying a protein called CEA. The study includes adults with advanced non-small cell lung cancer or breast cancer that has not responded to standard treatments.…

This study tests whether taking spirulina tablets before and after liver surgery can help protect the liver and speed up recovery. Thirty adults with bile duct cancer will take either spirulina or a placebo for three weeks before and after their operation. Researchers will measur…

This study tests whether adding a special type of radiation (SFRT) to standard treatment can help control non-small cell lung cancer that has started to grow again after initial therapy. About 25 adults with up to 5 progressing tumors will receive SFRT on those spots while contin…

This early-phase trial tests a new treatment using specially engineered immune cells (CAR-NK cells) that target a protein called CD70 found on cancer cells. The study enrolls 25 adults with T-cell lymphoma or acute myeloid leukemia that has come back or not responded to standard …

This study is for people with breast cancer whose tumors did not shrink after two rounds of standard chemotherapy. Researchers want to see if adding a special type of radiation (SBRT) to the remaining chemotherapy can help eliminate the cancer more effectively. About 96 participa…

This early-stage trial tests a new method called PIPAC that sprays chemotherapy directly into the abdomen for people with colorectal cancer that has spread there. The study aims to find the safest dose and check for side effects. About 42 adults aged 18-75 with no other cancer sp…

This study tests a new combination of chemotherapy, an immunotherapy drug, and a diabetes medicine (sitagliptin) in people with a specific type of advanced colorectal cancer. The goal is to shrink tumors before surgery and improve outcomes. About 138 adults aged 18-75 with locall…

This study tests a new way to deliver anti-VEGF drugs directly into the cornea to treat abnormal blood vessel growth caused by herpes simplex keratitis. The approach aims to be more targeted and longer-lasting than standard treatments. About 100 adults who have not had prior anti…

This study tests whether combining two drugs—cadonilimab and anlotinib—can help people with advanced or metastatic soft tissue sarcoma whose cancer worsened after standard first-line therapy. The trial enrolls 27 adults with various sarcoma subtypes. The main goal is to see how l…

This study is for people with solid tumors that have spread to the lining of the brain and spinal cord (leptomeningeal metastasis). Researchers want to see if combining whole-brain radiation with a chemotherapy drug (thiotepa) given into the spinal fluid, along with ongoing treat…

This study looks at whether using one closure device instead of two is just as safe for closing the blood vessel after a minimally invasive heart valve replacement (TAVR). About 876 people with severe aortic stenosis will take part. The goal is to see if using a single device can…

This study tests whether adding a chemotherapy drug (thiotepa) injected into the spinal fluid can improve outcomes for people with glioblastoma that has spread to the brain's lining or fluid spaces. About 38 adults will receive surgery, radiation, and standard oral chemo plus the…

This study tests whether adding the immunotherapy drug adbelimumab to standard chemotherapy and the targeted drug apatinib can help shrink esophageal cancer before surgery. About 35 adults with resectable stage II–IVA esophageal squamous cell carcinoma will receive this combinati…

This study tests if a device placed near the spinal cord (epidural electrical stimulation) can safely improve movement and sensation in people with chronic spinal cord injury. Ten adults with injuries above the T10 level will receive the implant and undergo personalized stimulati…

This early-stage study is testing a new treatment called LILRA6 CAR-T for adults with acute myeloid leukemia (AML) that has come back or not responded to standard therapy. The treatment uses a patient's own immune cells, which are modified in a lab to better recognize and attack …

This study is testing a new, non-invasive eye scan to see if it can detect Parkinson's disease in its early stages. Researchers will compare the scan's accuracy against standard brain imaging in 200 participants, including people with early Parkinson's, related movement disorders…

This study will collect MRI scans from 3,000 adults with brain tumors (gliomas, metastases, or lymphoma) to train an artificial intelligence system. The goal is to help doctors identify tumor types more accurately without surgery, potentially reducing the need for biopsies. Parti…

This study compares a new type of CT scanner (photon-counting CT) with standard CT to see if it can better detect very small blood clots in the lungs, called subsegmental pulmonary embolism. About 696 adults with suspected acute pulmonary embolism will be scanned with both method…

This study tests an artificial intelligence (AI) tool that can screen for heart valve disease using standard chest CT scans that people already get for other reasons. The goal is to catch moderate-to-severe valve problems earlier without extra tests or radiation. Researchers will…

This study uses artificial intelligence to analyze standard EKG results, aiming to more accurately diagnose hypertrophic cardiomyopathy (a thickened heart muscle) and tell it apart from other conditions that look similar. Researchers will enroll 15,000 adults, including those wit…

This study aims to improve diagnosis and treatment for people with complex cataracts and eye structure problems. Researchers will create full 3D models of the eye using multiple imaging techniques to help surgeons plan better and predict outcomes. About 1,200 participants with le…

This study aims to create a digital system that identifies older adults at risk for disability and provides personalized interventions to prevent it. Researchers will enroll 238 community-dwelling adults aged 65 and older who can use a smartphone. The system will be tested in urb…

This study tests a non-invasive brain stimulation technique called intermittent theta-burst stimulation (iTBS) for social anxiety disorder. One hundred adults with social anxiety will receive either real iTBS to the left or right prefrontal cortex, or a sham (fake) treatment, for…

This study looks at whether people with moderate-to-severe inflammatory bowel disease (IBD) need to routinely take dexamethasone (a steroid) before receiving infliximab to prevent allergic reactions. Researchers will compare those who get the pre-medication as usual with those wh…

This study tests whether a non-opioid pain medicine combination (celecoxib plus acetaminophen) works as well as an opioid-based combination (oxycodone plus acetaminophen) for pain after minimally invasive ankle surgery. 110 adults aged 18-65 will be randomly assigned to one of th…

This study looks at whether fecal microbiota transplantation (FMT) can reduce or prevent stomach and bowel side effects from chemotherapy in people with advanced gastrointestinal cancers. About 90 adults with stage IV cancer will receive FMT during their 4th chemo cycle. The goal…

This study tests whether pressing tiny seeds on specific ear points, combined with a steroid drug (dexamethasone), can prevent or reduce nausea and vomiting caused by chemotherapy in breast cancer patients. About 25 adults who need chemo after breast cancer surgery will try this …

This study compares two treatments for early frozen shoulder (adhesive capsulitis): manipulation under anesthesia and a supervised home rehabilitation program. Researchers will enroll 300 adults aged 40 to 80 who have had symptoms for 3 months or less. The goal is to see which ap…

This study tests whether pressing small seeds on specific ear points, combined with a steroid drug, can prevent or reduce nausea and vomiting caused by a breast cancer treatment. About 25 people with advanced breast cancer will try this approach and track their symptoms for five …

This study tests whether pressing tiny seeds on specific ear points, combined with a steroid drug, can better prevent nausea and vomiting from chemotherapy in pancreatic cancer patients. About 25 adults will receive the treatment before chemo and track their symptoms for five day…

This study tests whether a simple shot in the buttock works as well as an ultrasound-guided shot into the shoulder joint for treating frozen shoulder. About 528 adults aged 18 to 65 with frozen shoulder will receive one injection and be followed for 12 weeks. The goal is to see w…

This study tests whether applying herbal pastes to specific acupoints can relieve constipation and qi deficiency in people with colorectal cancer who have had chemotherapy. About 106 adults will receive either the acupoint treatment or standard care. The goal is to improve bowel …

This study tests whether giving a nerve block before ankle surgery can lower pain and help people recover faster. About 70 adults having ankle arthroscopy will receive either a nerve block or a placebo injection, and researchers will track their pain scores, opioid use, and ankle…

This study tests whether a non-invasive brain stimulation technique called iTBS can help reduce PTSD symptoms when added to standard care. About 140 adults with PTSD will receive the treatment, which uses magnetic pulses to target a brain area involved in movement and possibly em…

This study tests a new, faster type of brain stimulation called accelerated intermittent theta burst stimulation (AiTBS) to see if it relieves nerve pain better than standard treatment. About 120 adults with moderate to severe nerve pain will receive either AiTBS or standard 10-H…

This study is testing a single dose of a new pain medicine called tegileridine fumarate to find the best amount for controlling pain after orthopedic surgeries like hip or knee replacement. About 180 adults will receive the drug right after surgery, and researchers will adjust th…

This study aims to build an AI system that can predict if and where breast cancer will spread to other parts of the body, like the bones, lungs, liver, or brain. Researchers will analyze tumor samples and health data from 2000 women with breast cancer to train the AI. The goal is…

This study uses artificial intelligence to analyze standard tissue samples from 400 women with breast cancer. The goal is to see if the AI can accurately predict whether the cancer will spread to other parts of the body years after surgery. If successful, this tool could help doc…

This study watches 330 people with dilated cardiomyopathy (an enlarged, weak heart) to see if problems in the heart's tiny blood vessels lead to worse outcomes like heart failure or death. Researchers will track major heart events over time. No treatment is given—just observation…

This study follows thousands of liver transplant recipients and living donors over many years to track their health and any problems after surgery. Researchers collect medical data and surveys to find out what factors lead to better or worse outcomes. The goal is to create a pers…

This study explores a new way to measure anesthesia depth by analyzing chemicals in a patient's exhaled breath. Researchers will enroll 500 adults having surgery to see if breath levels of two anesthetics match standard brain-activity monitors. The goal is to develop a non-invasi…

This study aims to find biological markers that can predict whether a person with idiopathic normal pressure hydrocephalus (iNPH) will improve after a ventriculoperitoneal (VP) shunt surgery. Researchers will analyze spinal fluid and brain scans from 40 older adults before and af…

This study uses powerful 7T MRI brain scans and visual perception tests to find biological markers for severe mental disorders like major depression, schizophrenia, and bipolar disorder. Researchers will compare 320 patients and healthy volunteers aged 18-45 to improve diagnosis …

This study follows 500 people who are already scheduled for minimally invasive shoulder or knee surgery for sports injuries like torn ligaments or rotator cuff tears. Researchers will track their recovery for two years using questionnaires about pain and function. The goal is to …

This study is testing whether an artificial intelligence (AI) system can accurately identify different types of lung cancer by analyzing PET/CT scans and patient information like age, smoking history, and blood markers. Researchers will enroll 5,500 adults with newly diagnosed lu…

This study looks at whether common weight-loss medications like semaglutide and tirzepatide can slow or reverse genetic aging in adults with obesity. Researchers will measure changes in biological age using a special DNA test over 24 weeks. The goal is to see if these drugs do mo…

This study explores whether high-density brain surface recordings can decode imagined Mandarin Chinese speech, including tones, without any actual speaking. About 50 adults with brain conditions like epilepsy or tumors, plus 10 with severe speech loss from stroke or ALS, will hav…

This study looks at 450 people with central lung cancer who need a sleeve lobectomy (removing a tumor and part of the airway). It compares two minimally invasive techniques: robotic-assisted surgery (RATS) and video-assisted surgery (VATS). The goal is to see which approach leads…

This study looks at how X-ray radiation used during cancer surgery changes red blood cells. Researchers will take blood from 20 patients having tumor surgery and test it with different radiation doses. They want to find the safest dose that doesn't damage the blood cells too much…

This study is following 10,000 adults with heart valve disease to learn how the condition changes over time. Researchers will use scans and tests to track disease progression and see how treatments like surgery, medications, or lifestyle changes may affect outcomes. The goal is t…

This study looks at how two common endoscopic treatments for bleeding veins in the esophagus (band ligation and sclerotherapy) change pressure in the liver's portal vein over 3-6 months. Researchers will use a special ultrasound technique to measure pressure more accurately. The …

This study looks at gum tissue from people with aggressive periodontitis, chronic periodontitis, and healthy gums to understand what makes the aggressive form different. Researchers will use advanced genetic techniques to map out the types of cells and their activity in the tissu…

This study follows 1,850 people with bronchiectasis, a chronic lung condition, for three years. Researchers collect sputum samples monthly to analyze how bacteria in the lower airways evolve and adapt. The goal is to understand which bacterial changes lead to sudden worsening of …

This study looks for early biological markers in the blood that could predict dry mouth in head and neck cancer patients before symptoms appear. Researchers will collect blood samples from 126 patients before and after radiation therapy and use advanced techniques to find these m…

This study looks at how the brains of 25 stroke patients with weak hand muscles work when they do mirror movements. Researchers use a special brain scanner to measure activity. The goal is to learn more, not to test a treatment.