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Scientists probe gum tissue to unlock secrets of aggressive periodontitis

NCT ID NCT07487272

Knowledge-focused Sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This observational study looks at gum tissue from people with aggressive or chronic periodontitis and healthy gums. Researchers use advanced genetic tools to map cell types and signals that make aggressive disease different. Only small tissue and blood samples are taken during planned dental procedures, with no extra treatment or visits.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 9 people

The number the study aims to enrol. It can still change while the study runs.

Started

Dec 2025

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

This cross-sectional observational study will recruit 9 adults (n=3 per group) from the Department of Periodontology, Second Affiliated Hospital, Zhejiang University School of Medicine. All participants are already scheduled for routine tooth extraction or periodontal surgery, allowing incidental collection of a small gingival tissue sample (\~1×3×1 mm) and 5 mL peripheral blood during standard care. No extra procedures are added. Aggressive Periodontitis (AP) Group (n=3) Age 20-35 years * 30% vertical bone loss at ≥2 sites on radiographs Stage III/IV, Grade C (2018 classification) With or without family history Minimal local factors (negligible calculus/trauma) Chronic Periodontitis (CP) Group (n=3) Age 30-40 years * 3 sites with probing depth ≥5 mm Stage I/II, Grade A/B (2018 classification) No family history Disease driven by plaque/calculus Healthy Controls (n=3) Age 20-40 years No significant bone loss on radiographs Clinically healthy periodontium (no gingivitis/periodontitis)

Ages

20 to 40 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: Aggressive Periodontitis Patients: 1. Aged 20-35 years 2. Radiographic evidence of at least 30% vertical bone loss at ≥2 tooth sites 3. Can be classified as Stage III/IV, Grade C periodontitis according to the 2018 new classification of periodontitis 4. With or without family history of periodontitis 5. No significant local contributing factors (e.g., calculus, occlusal trauma, etc.) Chronic Periodontitis Patients: 1. Aged 30-40 years 2. ≥3 sites with probing depth ≥5 mm 3. Can be classified as Stage I/II, Grade A/B periodontitis according to the 2018 new classification of periodontitis 4. No significant family history 5. Disease predominantly driven by local factors (dental plaque, calculus, etc.) Healthy Controls: 1. Aged 20-40 years 2. Radiographic examination shows no significant alveolar bone loss 3. Clinically cannot be diagnosed with gingivitis or periodontitis Exclusion Criteria: 1. Use of antibiotics within the past 3 months 2. Smoking \>10 cigarettes per day 3. Uncontrolled severe diabetes (HbA1c level ≥6.7%) 4. Planning pregnancy, currently pregnant, or breastfeeding 5. Alcohol or drug addiction 6. Long-term use of immunosuppressive agents 7. Infectious diseases such as hepatitis or AIDS/HIV 8. History of malignant tumor, radiotherapy, or chemotherapy within the past 5 years

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Conditions

The condition(s) this trial relates to.

chronic periodontitis periodontitis periodontitis, aggressive periodontitis, aggressive 1

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Aggressive periodontitis Periodontis

How to take part

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  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • 2nd Affiliated Hospital, School of Medicine, Zhejiang University, China

    RECRUITING

    Hangzhou, Zhejiang, China

More trials for these conditions

Other studies related to the condition(s) this trial covers.