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Gentle gum therapy could heal bone defects without surgery

NCT ID NCT03741374

Disease control Sponsor: Queen Mary University of London Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled This study
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a minimally-invasive non-surgical therapy (MINST) for treating gum disease-related bone defects. The approach uses small instruments and magnification to clean deep gum pockets with less tissue damage than traditional surgery. Researchers will measure bone healing and gum health in adults with chronic periodontitis over 12 months.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Minimally-invasive non-surgical therapy (MINST)
What this could lead to
If successful, this approach could offer a less painful, non-surgical option for treating gum disease-related bone damage, potentially improving healing and reducing the need for surgery.
What could go wrong
This is an early observational study without a control group, so results may not prove the therapy is better than standard care. The technique requires specialized training and equipment, limiting widespread use.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Started

Feb 2019

Finished

Apr 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 70 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Age 18-70 2. Diagnosis of Periodontitis (Tonetti et al. 2018) 3. Presence of ≥1 'intrabony defect' (PPD and CAL \>5 mm with radiographic intrabony defect depth ≥3mm and not in a site associated with furcation involvement) 4. Signed informed consent \[Participants must be able and willing to read and sign a copy of the "Informed Consent Form" (ICF) form after reading the "Patient Information Leaflet" (PIS), and after the nature of the study has been fully explained\]. Exclusion Criteria: 1. Smoking (current or in past 5 years, including electronic cigarettes, vaping or similar) 2. Medical history including diabetes or hepatic or renal disease, or other serious medical conditions or transmittable diseases 3. Presence of drug-induced gingival enlargement 4. History of conditions requiring prophylactic antibiotic coverage prior to invasive dental procedures 5. Anti-inflammatory or anticoagulant therapy during the month preceding the baseline exam 6. Systemic antibiotic therapy during the 3 months preceding the baseline exam, 7. Taking immunosuppressant medications 8. Known allergy to local anaesthetic 9. History of alcohol or drug abuse 10. Self-reported pregnancy or lactation 11. Other severe acute or chronic medical or psychiatric condition or laboratory abnormality that according to the investigator may increase the risk associated with trial participation 12. Periodontal treatment to the study site within the last 12 months (excluding not-extensive subgingival debridement as judged by the examining clinician).

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Conditions

The condition(s) this trial relates to.

chronic periodontitis periodontitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Chronic periodontitis

Contacts and locations

Locations

  • Claremont Dental Practice

    Middlesex, TW1 3EJ, United Kingdom

  • Clinica de Periodoncia

    A Coruña, 15003, Spain

  • Dr Ryan Lee Private Practice

    Brisbane, QLD 4000, Australia

  • High Barnet Dental Care

    London, EN5 5UR, United Kingdom

  • Pall Mall Dental

    London, SW1Y 5LU, United Kingdom

  • Ravenscourt Dental Practice

    London, W6 0SL, United Kingdom

  • South Coast Dental Specialists

    Dorchester, DT1 1DT, United Kingdom

  • Studio Dentistico Associato Montevecchi D'Alessandro

    Forlimpopoli, 47034, Italy

  • The Dentist

    London, CM23 3AZ, United Kingdom

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