Second Affiliated Hospital, School Of Medicine, Zhejiang University

This study compares two common fertility treatments—ICSI and conventional IVF—in couples with unexplained infertility. Researchers want to see which method leads to more live births. About 848 couples in China will take part, all trying IVF for the first time.

This study explores a new surgical approach for women with early-stage breast cancer. During nipple-sparing mastectomy, if cancer is found in the nipple, doctors will remove the nipple but try to preserve the areola and rebuild a new nipple in the same surgery. About 40 women wil…

This study tests a new mouthwash called Amphion in 60 adults with gum disease (periodontitis). Participants will use the mouthwash along with standard deep cleaning to see if it reduces plaque and gum bleeding better than cleaning alone. The mouthwash works by forming a physical …

This study tests whether adding the blood thinner rivaroxaban to standard aspirin and clopidogrel can improve slow blood flow in heart attack patients who have had a stent placed. About 60 adults will receive either the triple therapy or standard dual therapy for one month. Resea…

This study tests a new treatment for people with a rare heart condition called light-chain cardiac amyloidosis that has not responded to standard therapy. The treatment uses specially engineered immune cells (CAR-NK cells) from donated umbilical cord blood to target and attack th…

This study tests a new combination of three drugs (lisafotoclax, decitabine, and homoharringtonine) in 35 adults with acute myeloid leukemia (AML) whose cancer did not respond to or could not tolerate a common first treatment. The goal is to see if this new mix can shrink or elim…

This early-phase study tests a new cell therapy called CNK-UT009 in 40 people with severe inflammatory bowel disease (Crohn's or colitis) that hasn't improved with standard treatments. The main goals are to check safety and find the best dose, while also looking at how well it wo…

This study tests a drug called ivarmacitinib for people with polymyalgia rheumatica, a condition causing muscle pain and stiffness. The goal is to see if it can control the disease without needing steroids. About 80 adults aged 50-75 will take either the drug or a placebo, and re…

This study tests whether the drug finerenone can help people with heart failure who have had a heart valve replacement (TAVI). About 2,800 participants will receive either finerenone or a placebo. The goal is to see if the drug reduces the risk of death or worsening heart failure…

This study tests whether adding bisphosphonates (a bone-strengthening drug) to the standard antibiotic vancomycin can better control chronic bone infections that are hard to treat. About 280 adults with a specific type of osteomyelitis will be randomly assigned to get either the …

This study tests whether a simple stool test can help doctors choose the right antibiotics for people whose H. pylori infection did not clear after standard treatment. About 531 adults aged 18-70 who have failed one prior treatment will be assigned to either a personalized antibi…

This study tests whether giving a combination of three drugs (camrelizumab, chemotherapy, and ivarmacitinib) before surgery can improve outcomes for people with a type of esophageal cancer. About 45 adults with stage II to IVA esophageal squamous cell carcinoma will receive this …

This study tests a combination of three drugs (liposomal irinotecan, temozolomide, and bevacizumab) in 24 people with advanced soft tissue sarcoma that has come back or not responded to prior treatment. The goal is to see if the combo can slow tumor growth and control the disease…

This early-stage trial tests whether a second infusion of a patient's own modified immune cells (CAR-DC) can safely improve heart function in people with end-stage dilated cardiomyopathy. The cells target a protein called FAP to calm harmful inflammation. Only 5 adults who previo…

This study tests a treatment called photodynamic therapy (PDT) that uses a light-sensitive drug and a special light to destroy abnormal cervical cells caused by HPV types 16 or 18. About 225 women with low-grade cervical lesions will either receive PDT or be watched without treat…

This study tests whether adding a probiotic called Lactobacillus johnsonii to standard chemotherapy and immunotherapy can help control advanced lung, breast, or stomach cancers. About 156 adults with these cancers will be randomly assigned to receive either the probiotic or a pla…

This study tests two injected medications, bleomycin and pingyangmycin, to treat stubborn plantar warts. Two hundred adults with at least two warts will get one drug on half their warts and the other on the rest, so each person acts as their own comparison. The goal is to see whi…

This early-stage trial tests a new treatment made from donor cells (CAR-DC) for people who have had a severe heart attack and are in shock. The goal is to see if it is safe and can help the heart recover. The study will include 18 adults who have already had emergency heart proce…

This study tests whether icaritin soft capsules, taken after surgery, can help prevent liver cancer from returning in patients at high risk of recurrence. About 25 adults will take the capsules and be monitored for tumor response and side effects. The goal is to improve long-term…

This study compares two surgical approaches for people with early-stage thyroid cancer located in the isthmus (the bridge of the thyroid). One group will have only the tumor and nearby lymph nodes removed, while the other group will have the entire thyroid removed. The goal is to…

This study looks at whether combining an antibody drug (anti-IL-17A/F) with a special laser can safely reduce symptoms of hidradenitis suppurativa, a chronic skin condition causing painful lumps. About 50 adults with mild to moderate disease will receive the combination every 4 w…

This study tests the drug everolimus in people with advanced colorectal cancer that has a specific genetic marker (CDK12 deficiency) and has not responded to other treatments. The goal is to see if the drug can shrink tumors or slow the disease, and to find the safest dose. About…

This study tests a treatment using bacteriophages—viruses that naturally kill bacteria—to fight stubborn infections around orthopedic implants like joint replacements. About 100 adults will receive the therapy, and doctors will check if the infection clears by testing samples ove…

This study tests the drug mavacamten in 132 people with hypertrophic cardiomyopathy (thick heart muscle) that blocks blood flow in the middle to lower part of the heart. The goal is to see if the drug reduces the pressure buildup in the heart during a breathing maneuver over 36 w…

This early-phase trial tests a new treatment for recurrent glioblastoma, an aggressive brain cancer. The therapy uses a patient's own immune cells, engineered to better target and attack cancer cells. The study aims to see if this approach is safe and shows early signs of shrinki…

This study tests whether monoclonal antibody drugs can slow the progression of Alzheimer's disease in 120 people with mild cognitive impairment or mild Alzheimer's. Researchers will use PET scans to measure brain changes and see who benefits most from continued treatment, even if…

This study tests two experimental drugs, MRG003 and QL1706, together in people with recurrent or metastatic cervical cancer that has worsened after standard platinum chemotherapy. The goal is to see if the combination can shrink tumors. About 41 adults will take part. This is not…

This early-phase study tests whether a new type of cell therapy, called CAR-DC, is safe for people with severe heart failure due to blocked arteries. The therapy uses a patient's own immune cells, modified to target a protein called FAP that is linked to heart scarring. Fifteen a…

This study tests three ways to manage the nerve inside a wisdom tooth after it's moved to replace a broken molar. About 360 adults aged 18-40 will be randomly assigned to one of three groups: standard root canal weeks later, a special root tip treatment during surgery, or just tr…

This study looks at whether keyhole surgery (laparoscopic) or traditional open surgery leads to better long-term outcomes for colon cancer patients who have extra belly fat. About 664 adults aged 18 to 75 with colon cancer and a high Body Roundness Index will take part. The main …

This study tests if a drug-coated balloon is as safe and effective as a drug-coated stent for treating large blockages in heart arteries. About 2,492 people with coronary artery disease will be randomly assigned to one of the two treatments. Doctors will use special imaging to gu…

This study tests whether using a laser along with ultrasonic cleaning is as good as the standard manual plus ultrasonic cleaning for treating advanced gum disease. About 174 adults with severe periodontitis will receive one of the two treatments. The goal is to see if the laser m…

This study tests whether adding the experimental drug Ivonescimab to standard chemotherapy before surgery can improve outcomes for people with resectable esophageal squamous cell carcinoma. About 49 adults with stage II to IVA cancer will receive the combination, then have surger…

This study tests whether a medicine given as a nose spray before a heart procedure can reduce heart muscle damage or heart attacks. About 1800 adults with coronary heart disease will receive either the spray or a placebo 15 minutes before their procedure. Researchers will check b…

This early-stage study tests whether tendon stem cells can safely improve healing in people with small to medium rotator cuff tears. About 107 adults aged 18-70 who still have pain after 3 months of other treatments will receive the cells during surgery. The goal is to see if thi…

This study tests a combination of three drugs (Benmelstobart, Anlotinib, and Cyclophosphamide) in 40 adults with recurrent ovarian, fallopian tube, or primary peritoneal cancer. The goal is to see if this mix can control the cancer longer and improve survival. Participants must h…

This early-stage trial tests a new gene therapy for Parkinson's disease. Six adults aged 40-70 with advanced Parkinson's will receive a brain injection of a specially designed virus (STP-001) that delivers a gene to calm overactive brain cells. After surgery, they will take a pil…

This study tests whether leaving the needle biopsy tract in place during sarcoma surgery is as safe as removing it. About 3,300 people with extremity sarcoma will be randomly assigned to have the tract removed or not. The goal is to see if skipping removal lowers the chance of ca…

This study tests whether eating foods with resistant starch (a type of fiber) can slow down memory loss in people at high genetic risk for cognitive decline. About 70 adults aged 40 and older with certain risk factors will be randomly assigned to eat either high-resistant starch …

This study tests whether combining two drugs, tofacitinib and imatinib, can safely treat moderate-to-severe palmoplantar pustulosis (PPP), a rare skin disease causing painful pustules on the palms and soles. About 135 adults will receive either the drug combination or a placebo f…

This study looks at how well CGRP-targeted medications work for people with vestibular migraine, a condition that causes severe dizziness and vertigo. Researchers will enroll 2,000 Chinese adults aged 18 to 75 to see if these drugs can reduce dizziness episodes and improve daily …

This study tests a device called Adacolumn that filters certain white blood cells from the blood. The goal is to see if it can reduce dangerous brain swelling in the first 72 hours after a severe stroke. Ten adults with a blocked major artery in the brain will receive this treatm…

This study tests whether the drug surufatinib can help prevent neuroendocrine tumors (NETs) from returning after surgery. It enrolls 35 adults with stage III NETs who are at high risk of recurrence. Participants will take surufatinib after their operation, and researchers will tr…

This early-stage trial tests a new cell therapy for people with end-stage idiopathic pulmonary fibrosis (IPF), a severe lung scarring disease. The therapy uses specially engineered immune cells to target and calm the cells that cause scarring. The study will check if the treatmen…

This study compares a light-based treatment called photodynamic therapy (PDT) to a common surgical procedure (LEEP) for women with high-grade cervical lesions (HSIL/CIN2) caused by HPV. The goal is to see if PDT is as effective as surgery at clearing these abnormal cells, while p…

This study is testing a new blood test that uses artificial intelligence to analyze DNA fragments in the blood. The goal is to see if it can accurately determine the stage of breast cancer and whether it has spread to lymph nodes, potentially reducing the need for surgery. The st…

This study aims to create an artificial intelligence (AI) tool that can better predict the risk of a heart attack within the next 6 months. Researchers will collect and analyze data from 1500 adults who have already had a heart attack and undergone a stent procedure. The goal is …

This study aims to create an AI system that can detect breast cancer early using plain MRI scans—no contrast dye needed. It will involve 30,000 women aged 30-70 across multiple centers. The goal is to make breast cancer screening safer, more accurate, and more accessible, especia…

This study looks at whether adding a gentle nerve stimulation device (taVNS) to a standard epidural injection can better relieve pain from pinched nerves in the neck. About 80 adults with cervical radiculopathy will be randomly assigned to get either the real device or a sham dev…

This study tests a non-invasive device that gently stimulates a nerve in the ear to see if it can reduce pain and the need for strong painkillers after complex spinal surgery. About 98 adults will be randomly assigned to receive either the real stimulation or a sham (fake) treatm…

This study tests a new way to treat narrowed sections of the small intestine caused by Crohn's disease. It compares a precise incision method using a balloon-assisted scope to the standard balloon dilation. The goal is to see which approach better relieves symptoms and keeps pati…

This study compares two methods to keep the surgical area clear during ankle arthroscopy: using a dilute epinephrine solution versus a tourniquet. About 88 patients aged 15 to 65 with ankle conditions will participate. The goal is to see if the epinephrine method provides equal o…

This study compares three types of anesthesia for people having ankle surgery to see which one helps them recover and go home faster. Two hundred adults will be randomly assigned to receive either total intravenous anesthesia, general anesthesia, or spinal anesthesia, all combine…

This study tests whether papaverine, a drug that relaxes blood vessels, can relieve nerve pain and numbness caused by taxane chemotherapy. It includes 43 adults whose symptoms have not improved with standard treatments. Participants receive papaverine infusions once a week for up…

This study tests whether a drug called butylphthalide can help control symptoms of multiple system atrophy (MSA), a rare brain disorder that affects movement and automatic body functions. About 150 adults aged 30 to 80 with early-stage MSA will take either the drug or a placebo f…

This study looks at whether breathing pure oxygen in a pressurized chamber (hyperbaric oxygen therapy) can help people with a recent ankle sprain recover faster. Researchers will measure pain, swelling, and ankle function in 208 adults over 3 years. The goal is to see if this tre…

This study looks at whether adding a traditional Chinese herbal formula (Liqin Zhike) to standard asthma inhalers can improve outcomes for people with cough variant asthma. About 236 adults aged 18-70 with a new diagnosis will be followed to see if the combination lowers the chan…

This study looks at whether the drug amisulpride can prevent nausea and vomiting after gynecological laparoscopic surgery. About 526 patients will take part. The main goal is to see how many patients have no vomiting and don't need extra anti-nausea medicine within 24 hours after…

This study tests a new way to treat depression that can happen after a stroke. It combines virtual reality mindfulness therapy (like a calming VR game) with a gentle brain stimulation technique called tDCS. The goal is to see if using both together works better than either one al…

This study tests whether electroacupuncture (a gentle electric current applied to acupuncture points) can improve thinking and memory in people who have cognitive problems after a stroke. About 110 participants will be randomly assigned to receive either real electroacupuncture o…

This study looks at whether a lower dose of the drug lecanemab can work as well as the standard dose for people with early-stage Alzheimer's disease. About 140 adults aged 50-85 with mild cognitive impairment or mild Alzheimer's will be followed for 18 months. Researchers will co…

This study tests whether injecting a long-lasting numbing medication (liposomal bupivacaine) into the scalp before a brain surgery incision can reduce pain for up to 72 hours after the operation. About 100 adults scheduled for microvascular decompression (a surgery to relieve ner…

This study tests a non-invasive device that gently stimulates a nerve in the ear to see if it can reduce anxiety in people having major abdominal surgery. Over half of these patients experience anxiety, which can slow recovery. The trial will involve 282 adults who will receive e…

This study will create a biobank by collecting blood, tissue, and other samples from 300 people with liver, bile duct, or pancreatic tumors, as well as from people with benign conditions and healthy volunteers. No experimental treatments or extra procedures are involved—samples a…

This study tests an AI system called LingBao that helps doctors make quick, informed decisions about stroke treatments like clot-busting drugs or procedures to remove clots. About 3,000 adults with acute ischemic stroke will take part across 20 hospitals. The goal is to see if us…

This study aims to create a more accurate way to predict serious heart problems after a heart attack. Researchers will use advanced data analysis on information from about 1,500 adults who have had a heart attack and a stent procedure. The goal is to help doctors better identify …

This study compares two types of ventilators used to help patients breathe during transport within or between hospitals. The goal is to see if a new ventilator keeps oxygen levels as stable as a current model. About 98 adults on breathing machines will be randomly assigned to one…

This study looks at how a new pain drug, Anrikefon, works in people aged 65 and older after laparoscopic abdominal surgery. Thirty participants will receive the drug and have their blood levels measured. The goal is to understand how the drug behaves in older adults, not to prove…

This study aims to see if a computer can learn to predict how well a treatment for a certain type of vision loss will work over two years. The treatment involves regular eye injections for a condition called myopic choroidal neovascularization, which can cause blindness. Research…

This study surveys over 13,000 healthcare workers in Chinese emergency rooms to see how well they understand and follow pain and sedation guidelines. It aims to find gaps in knowledge and practice, so hospitals can improve care for patients in critical situations. No new treatmen…

This study uses a realistic simulator to see if a special 3D lung display, called a 'Digital Twin,' helps ICU doctors feel less stressed and find breathing problems faster. About 34 doctors will try both the standard monitor and the new display during four emergency scenarios. Th…

This study looks at past and future patients to build a tool that predicts whether colorectal adenomas (precancerous polyps) will return after removal. Researchers will collect lifestyle information and blood samples from 1,280 adults aged 18-75. The goal is to improve follow-up …

This study tests a technique called Episodic Future Thinking (EFT) to encourage physical activity in older adults with motoric cognitive risk syndrome (MCR), a condition that raises dementia risk. Researchers will compare EFT to a control group in 166 participants. The goal is to…

This study aims to create an AI tool that analyzes standard liver cancer tissue images to predict which patients will benefit from additional treatments after surgery. The goal is to avoid unnecessary side effects and improve outcomes by personalizing care. The study will involve…

This study looks at 40 men having surgery for a narrowed urethra. It compares two ways of removing hair before surgery to see which one better reduces bacteria on the skin and lowers the chance of infection. The goal is to find the best method to prevent surgical site infections.

This study aims to create an artificial intelligence (AI) system that can combine medical images (like CT or MRI scans) with patient records to help doctors diagnose liver, gallbladder, and pancreas diseases more accurately. The researchers will use data from 2,000 adult patients…