Second Affiliated Hospital, School Of Medicine, Zhejiang University

This early-stage study tests a personalized vaccine made from a patient's own tumor mutations. It is given to 27 people with esophageal cancer who have already completed surgery and standard follow-up treatments. The goal is to see if the vaccine is safe and can help prevent the …

This study tests a new way to remove kidney stones (2-4 cm) called VISOR, comparing it to standard surgery (PCNL). About 170 adults will be randomly assigned to one of the two procedures. Researchers will check how many are stone-free within 24 hours and at 1 month, and track sid…

This study tests a new drug (orelabrutinib) combined with either low-dose radiation or another drug (rituximab) for a rare type of eye lymphoma called ocular adnexal MALT lymphoma. About 39 adults with early-stage disease who haven't had prior treatment will participate. The goal…

This study tests two drug combinations for people with advanced colorectal cancer that has a specific genetic change called KRAS G12C. In one group, patients who haven't had treatment before will get the drugs IBI351 and cetuximab plus chemotherapy. In another group, patients who…

This phase 3 trial tests whether adding the immunotherapy drug sintilimab to standard chemotherapy and bevacizumab helps people with a specific type of advanced colorectal cancer (RAS-mutant, microsatellite stable) live longer without their cancer growing. The study involves 446 …

This study is testing whether adding the drug serplulimab to standard chemotherapy before surgery can help people with esophageal cancer. The goal is to see if this combination can shrink tumors more effectively and lower the chance of the cancer coming back. About 48 adults with…

This study tests whether adding a special shockwave treatment (intravascular lithotripsy) to standard artery-cleaning procedures helps people with moderate to severe calcium buildup in their heart arteries. About 1,096 adults with coronary artery disease will be split into two gr…

This study tests whether icaritin soft capsules can help prevent liver cancer from returning after surgery in patients at high risk of recurrence. Twenty adults who had their liver cancer completely removed will take the capsules and be monitored for up to 12 months with regular …

This study looks at whether giving the drug serplulimab together with chemotherapy before surgery can help people with a certain type of lung cancer (non-small cell lung cancer). The goal is to shrink tumors and make surgery more effective, possibly reducing the chance of cancer …

This study looks at whether giving antibiotics before an endoscopic procedure is necessary for cirrhosis patients who have had variceal bleeding before. The goal is to see if skipping antibiotics is just as safe and effective. About 226 adults with cirrhosis are taking part.

This study tests a safe, non-invasive treatment called distant ischemic adaptation for people who have had a stroke or have small vessel brain disease. The treatment involves briefly inflating a blood pressure cuff on the arm to trigger the body's natural protection. Researchers …

This study tests a new approach for treating deep brain bleeds. It combines a computer-guided, minimally invasive surgery to drain the clot with a clot-dissolving medicine. The goal is to see if this helps people recover better and regain independence compared to standard care. T…

This early-stage study tests whether beta-sitosterol, a safe plant compound found in traditional Chinese medicine, can help people recover from a severe type of stroke called subarachnoid hemorrhage. About 40 adults who had a bleeding stroke will receive beta-sitosterol within 48…

This study looks at 387 people having shoulder surgery for torn rotator cuff tendons. It compares two common injections—platelet-rich plasma (using your own blood) and corticosteroids—to see which works better for different tendon problem types. The goal is to find the best treat…

This study tests a small device that sends gentle electrical pulses to nerves far from the head (ultra-distal TENS) to ease migraine pain and symptoms like nausea. About 200 adults with frequent migraines will use the device during attacks. The goal is to see if it can reduce hea…

This study tests a new adaptive fluidics system that automatically adjusts fluid pressure during lens surgery to keep the eye stable and reduce risks. About 320 adults with lens diseases will be enrolled. The goal is to see if this technology improves safety and outcomes compared…

This study looks at brain tissue from 10 people with temporal lobe epilepsy and hippocampal sclerosis who are having surgery. Researchers will analyze gene activity in the tissue to understand what causes the disease and find possible markers for better treatment. The goal is to …

This study looks at how PET/CT scans can be used with artificial intelligence to better understand non-small cell lung cancer. Researchers will analyze scans from 500 patients to see if they can predict the cancer's stage, type, gene changes, and how it might progress. The goal i…

This study is looking at whether a special blood test that measures different types of cholesterol and fats can help predict if a heart stent will narrow again after it is placed. Researchers will study 3,600 adults who have had a stent placed in their heart arteries. The goal is…