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Could a gentle ear zap boost pain relief for pinched nerves?

NCT ID NCT07557823

Symptom relief Sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether a gentle electrical stimulation of the ear (taVNS) given before a standard epidural steroid injection can improve pain relief for people with cervical radiculopathy—a pinched nerve in the neck causing arm pain. Eighty adults will be randomly assigned to receive either real taVNS or a sham (fake) stimulation before their injection. The main goal is to see how many people have at least a 50% drop in pain the day after the procedure.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
transcutaneous auricular vagus nerve stimulation (taVNS) and cervical epidural injection of corticosteroid and local anesthetic
What this could lead to
If it works, this could offer a new, non-invasive way to boost pain relief for people with pinched nerves in the neck.
What could go wrong
This is a small, early-stage trial with no prior results. The nerve stimulation may not add benefit over the epidural injection alone, and some people may not respond.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 80 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Apr 2026

An estimate. Start dates often move.

Expected to finish

Mar 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 85 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Age between 18 and 85 years old. 2. Body Mass Index (BMI) between 18 and 35 kg/m². 3. American Society of Anesthesiologists (ASA) physical status I to III. 4. Diagnosed with cervical radiculopathy, scheduled for selective cervical epidural injection. 5. Estimated procedure duration ≤ 1 hour. 6. Able to understand and provide written informed consent. Exclusion Criteria: 1. Arrhythmia requiring treatment, severe bradycardia, or postural orthostatic tachycardia syndrome. 2. Neuromuscular disorders or auricular dermatitis. 3. Cervical fracture, tumor, tuberculosis, or active infection confirmed by imaging. 4. Contraindications to vagus nerve stimulation: carotid sinus hypersensitivity, bilateral carotid artery stenosis. 5. Severe psychiatric disorder or history of substance abuse.

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Conditions

The condition(s) this trial relates to.

agnosia Pain radiculopathy spondylosis spondylosis, cervical

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cervical radiculopathy Cervical spondylosis Radicular pain

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • The Second Affiliated Hospital, Zhejiang University School of Medicine Facility Address 88 Jiefang Road, Shangcheng District, Hangzhou, Zhejiang Province, 310009, P.R.China

    Hangzhou, Zhejiang, 310009, China

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