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Stem cells aim to fix torn shoulder tendons

NCT ID NCT07320378

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This early-phase trial tests whether tendon stem cells can help rotator cuff tears heal better after surgery. About 107 adults with small to medium tears will receive either standard repair or repair plus stem cells placed at the injury site. The study will check for side effects and measure shoulder function over time.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
tendon stem/progenitor cells (TSPCs) delivered on a fibrin glue scaffold
What this could lead to
If it works, this could lead to a treatment that helps tendons heal better after surgery, reducing the risk of re-tear and improving shoulder function.
What could go wrong
This is a very early (Phase 1) trial with only 107 people, so safety and effectiveness are not yet proven. Stem cell therapies can have side effects like infection or abnormal tissue growth.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Early phase 1

The earliest testing in people: a first look at safety, in a very small group.

Participants

About 107 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

May 2026

An estimate. Start dates often move.

Expected to finish

Jan 2029

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 70 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Aged between 18 and 70 years, regardless of gender; 2. Tear size classified as small (\< 1 cm) or medium-sized (1 cm to 3 cm) according to the DeOrio and Cofield classification system; 3. Persistent shoulder pain or functional limitations despite at least 3 months of non-surgical treatment, with indications for arthroscopic rotator cuff repair; 4. Willing to sign the informed consent form and agree to participate in this study. Exclusion Criteria: 1. Tear size classified as large (3 cm to 5 cm) or massive (\> 5 cm) according to the DeOrio and Cofield classification, or Patte grade 3 tendon retraction; 2. Subscapularis tendon tear; 3. Complicated with anterior, posterior, or multidirectional shoulder joint instability; 4. Indications for repair of anterior or posterior labral injury; 5. Intra-articular injection of hyaluronic acid or corticosteroids within 3 months prior to the planned surgery; 6. Comorbidities that contraindicate arthroscopic shoulder surgery; 7. Local (shoulder, abdomen, buttocks) or systemic infection, osteomyelitis, or sepsis; 8. Diabetes mellitus, untreated thyroid disease, chronic kidney disease, or rheumatoid arthritis; 9. Immunodeficiency; 10. Chronic diseases involving coagulation or platelet aggregation, or severe coagulopathy; 11. Severe cardiovascular disease; 12. Stroke or acute cardiovascular event within 6 months prior to the planned surgery; 13. Weight loss \> 30 kg for any reason within 12 months, or unexplained weight loss \> 10 kg within 12 months; 14. Eating disorder or body dysmorphic disorder; 15. Alcohol/drug addiction or mental illness that may affect compliance with postoperative protocols; 16. Pregnant or lactating women; 17. Refusal to sign the informed consent form; 18. Other conditions deemed inappropriate by the investigators.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

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