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Stem cells aim to fix torn shoulder tendons
NCT ID NCT07320378
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This early-phase trial tests whether tendon stem cells can help rotator cuff tears heal better after surgery. About 107 adults with small to medium tears will receive either standard repair or repair plus stem cells placed at the injury site. The study will check for side effects and measure shoulder function over time.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- tendon stem/progenitor cells (TSPCs) delivered on a fibrin glue scaffold
- What this could lead to
- If it works, this could lead to a treatment that helps tendons heal better after surgery, reducing the risk of re-tear and improving shoulder function.
- What could go wrong
- This is a very early (Phase 1) trial with only 107 people, so safety and effectiveness are not yet proven. Stem cell therapies can have side effects like infection or abnormal tissue growth.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Early phase 1
The earliest testing in people: a first look at safety, in a very small group.
- Participants
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About 107 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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May 2026
An estimate. Start dates often move.
- Expected to finish
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Jan 2029
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 70 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Aged between 18 and 70 years, regardless of gender; 2. Tear size classified as small (\< 1 cm) or medium-sized (1 cm to 3 cm) according to the DeOrio and Cofield classification system; 3. Persistent shoulder pain or functional limitations despite at least 3 months of non-surgical treatment, with indications for arthroscopic rotator cuff repair; 4. Willing to sign the informed consent form and agree to participate in this study. Exclusion Criteria: 1. Tear size classified as large (3 cm to 5 cm) or massive (\> 5 cm) according to the DeOrio and Cofield classification, or Patte grade 3 tendon retraction; 2. Subscapularis tendon tear; 3. Complicated with anterior, posterior, or multidirectional shoulder joint instability; 4. Indications for repair of anterior or posterior labral injury; 5. Intra-articular injection of hyaluronic acid or corticosteroids within 3 months prior to the planned surgery; 6. Comorbidities that contraindicate arthroscopic shoulder surgery; 7. Local (shoulder, abdomen, buttocks) or systemic infection, osteomyelitis, or sepsis; 8. Diabetes mellitus, untreated thyroid disease, chronic kidney disease, or rheumatoid arthritis; 9. Immunodeficiency; 10. Chronic diseases involving coagulation or platelet aggregation, or severe coagulopathy; 11. Severe cardiovascular disease; 12. Stroke or acute cardiovascular event within 6 months prior to the planned surgery; 13. Weight loss \> 30 kg for any reason within 12 months, or unexplained weight loss \> 10 kg within 12 months; 14. Eating disorder or body dysmorphic disorder; 15. Alcohol/drug addiction or mental illness that may affect compliance with postoperative protocols; 16. Pregnant or lactating women; 17. Refusal to sign the informed consent form; 18. Other conditions deemed inappropriate by the investigators.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- Can a Stomach-Derived peptide help tendons heal faster after surgery?
- Can a patch make torn shoulder tendons heal stronger?
- Blood-derived injections may mend torn shoulder tendons without surgery
- Ultrasound 'Tissue Stiffness' test could reveal hidden rotator cuff healing problems
- Which painkiller wins for shoulder surgery? a Head-to-Head test