NEUROPATHIC PAIN

This study tested whether a low-level electrical stimulation of nerves near the spine (DRG stimulation) can reduce chronic pain better than a placebo (sham). Twenty adults who already have a DRG stimulator implanted took part. Each person received both active stimulation and sham…

This study tested whether the drug brivaracetam can reduce the severe nerve pain that many people with spinal cord injury experience. About 44 adults with chronic spinal cord injury and persistent nerve pain took either the drug or a placebo for several weeks. Researchers measure…

This study looked at a targeted drug delivery system (a pain pump) versus standard pain pills for people with severe cancer pain. It included 30 adults whose pain was not controlled by high doses of opioids or who had bad side effects. The goal was to see if the pump could better…

This early-stage study tested a single dose of the experimental drug 4ET1103 in 40 healthy adults to see if it is safe and how the body processes it. Half received the drug, half a placebo, and all were monitored for side effects and changes in blood, urine, and vital signs. The …

This study tested a non-invasive brain stimulation technique called rTMS to see if it could reduce pain in people with chronic low back pain. Thirty adults received the treatment, and researchers measured their pain levels before and after. The goal was to find a drug-free way to…

This study looked at different rehabilitation programs for people who had back surgery for conditions like spinal stenosis or slipped vertebrae. The goal was to see which program best reduces nerve pain, helps patients get back to daily activities, and improves quality of life. 9…

This study tested whether adding a drug called dexmedetomidine to standard spinal anesthesia could reduce acute nerve pain after a leg amputation. Thirty adults having elective leg amputation took part. The experimental group received the extra drug, and researchers measured pain…

This study looked at whether medical cannabis can reduce nerve pain and inflammation in people with HIV. Thirty-five adults with HIV and neuropathic pain used medical cannabis with different levels of THC and CBD. Researchers tracked changes in pain scores and blood markers of in…

This study tested whether a single injection of a nerve block (called rhomboid intercostal block) after mastectomy can lower the chance of long-term pain. 254 women having breast cancer surgery were split into two groups: one got the nerve block, the other got no block. Researche…

This study tested a one-time pain management class for 110 youth aged 10 to 18 with chronic pain conditions like fibromyalgia or abdominal pain. The class taught pain science and self-regulation skills. Researchers checked if the class was easy to use and if it helped reduce how …

This study tested whether a gentle electrical stimulation (40 kHz) applied through the skin can safely reduce nerve pain in people with spinal cord injury. Thirty adults with paraplegia and chronic nerve pain received either real or placebo stimulation alongside their usual treat…

This study tested two types of non-invasive brain stimulation—intermittent theta burst (iTBS) and 10 Hz repetitive transcranial magnetic stimulation (rTMS)—against a fake treatment to see if they could reduce nerve pain in people with spinal cord injury. 26 adults with long-term,…

This study tested a new combination of two supplements (Nucleo CMP and Neurorubine) against the standard drug carbamazepine for treating trigeminal neuralgia, a severe facial pain condition. 38 adults with the condition were randomly assigned to one of the two treatments. The goa…

This study tested a device called the Sana Pain Reliever for people with long-term nerve pain. 75 adults used the device at home for 8 to 14 weeks. Researchers measured changes in pain and mood to see if the device helped.

This small study looked at 7 adults with long-term nerve pain (neuropathic pain) to see if taking memantine or dextromethorphan after a ketamine treatment could help maintain or improve pain relief. Participants had already responded well to ketamine. The study measured pain leve…

This study tested whether wearing special prism glasses (prism adaptation therapy) can reduce pain and improve movement in people with Complex Regional Pain Syndrome (CRPS) type I, a condition that causes severe, long-lasting pain often after an injury like a wrist fracture. Fift…

This pilot study tested whether combining ketamine with psychotherapy (cognitive behavioral therapy) helps people with chronic nerve pain more than either treatment alone. 30 adults with moderate-to-severe neuropathic pain were randomly assigned to receive ketamine, psychotherapy…

This study tested if a non-invasive brain stimulation technique called tDCS can reduce chronic nerve pain. Researchers compared real stimulation to a placebo in 24 people, including both healthy volunteers and patients with long-term nerve pain. The goal was to see if targeting a…

This study looked at whether certain health and wellness products can help reduce pain. Over 2,000 adults in the U.S. who wanted less pain took either an active product or a placebo without knowing which. The main goal was to see if the products reduced how much pain interfered w…

This study tested non-drug methods to reduce nerve pain in the feet and legs of people with HIV. 196 adults with HIV and long-term nerve pain took part. The goal was to see if these approaches could lower pain and improve daily life.

This study looked at whether progressive relaxation exercises can help people with type 2 diabetes who have nerve pain, fatigue, and poor sleep. 88 adults took part, and researchers measured changes in pain, tiredness, and sleep quality. The goal was to see if a simple, non-drug …

This study looked at how a non-invasive magnetic brain stimulation technique called rTMS changes brain activity in healthy volunteers and people with long-term nerve pain. Researchers measured brain responses before and after stimulation to see if these changes relate to pain rel…

This study tested an online tool (E-TOOL) designed to help doctors decide which patients with chronic pain might benefit from spinal cord stimulation. Researchers compared the tool's recommendations with the doctors' own opinions in 80 patients. The goal was to see if the tool co…

This study looked at 151 people with shingles to find out who might develop lasting nerve pain (postherpetic neuralgia). Researchers collected blood samples and health information to build a prediction model. The goal is to help doctors identify high-risk patients early and tailo…

This study tested whether culturally tailored videos could help Black and Hispanic adults with long-term nerve pain better understand and feel more positive about a treatment called nerve stimulation. 28 participants watched these videos and reported their expectations for pain r…

This study explored whether people with cervicogenic headache (headache coming from the neck) have more nerve pain and a hypersensitive central nervous system compared to healthy people. Researchers compared 72 adults with and without the condition using questionnaires about pain…

This study looked at 96 adults with nerve pain (neuropathic pain) who were treated with antiepileptic drugs. Researchers checked their vitamin B12 and folic acid levels before and after treatment to see if the medication changed these levels. The goal was to understand if people …

This study followed over 2,300 adults from urban areas of Chile for one year to learn more about chronic pain and its effects. Researchers measured pain levels, mental health issues like depression and anxiety, and how pain impacted work and social life. The goal was to better un…

This study looked at how spinal cord stimulation (SCS) affects the way chronic pain patients feel pain. 34 adults with long-term pain who already had SCS devices took part. Researchers tested different SCS settings to measure changes in pain perception, aiming to understand how t…