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Spinal zaps studied to Fine-Tune pain relief

NCT ID NCT04732325

Knowledge-focused Sponsor: University of Michigan Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looked at how spinal cord stimulation (SCS) affects pain processing in 34 people with chronic pain. Participants already had an SCS device as part of their care. Researchers tested different stimulation patterns (burst, kHz, tonic, and sham) to see how they changed the brain's response to pain. The goal was to understand how SCS works, not to test a new treatment.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Spinal cord stimulation (device)
What this could lead to
If successful, this could help doctors choose the best stimulation settings for individual patients to improve pain relief.
What could go wrong
This was a small, completed study that measured pain perception changes, not long-term outcomes. Results may not apply to all patients or lead to new treatments.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

34 people

The number who actually took part.

Started

Sep 2021

Finished

Jun 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion criteria: * Chronic intractable pain of the trunk and/or limbs * Undergoing SCS as part of standard clinical care for chronic pain management * Candidates will have been implanted with a commercial SCS device * Candidates who are 18 years or older and can speak, read, and understand English * Able to understand study procedures and to comply with them for the entire length of the study * Must be willing to participate in COVID-19 symptom screening and answer questions about COVID-19 diagnosis 1-3 days before a scheduled visit * Must be willing to wear a face-covering during all study visits Exclusion criteria: * Subjects who are pregnant or nursing * Subjects with current, habitual, or previous use within the last 12 months of artificial nails, nail enhancements, or nail extensions that cover any portion of either thumbnail * Subjects who are unable or unwilling to cooperate with clinical testing * Subjects having any impairment, activity or situation that in the judgment of study personnel would prevent satisfactory completion of the study protocol * Inability or unwillingness of individual or legal guardian/representative to give written informed consent * Subjects who currently have or tested positive in the last 14 days for COVID-19, or are symptomatic for COVID-19

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Conditions

The condition(s) this trial relates to.

Chronic Pain chronic pain syndrome complex regional pain syndrome Failed Back Surgery Syndrome neuralgia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Chronic pain Complex regional pain syndromes Failed back surgery syndrome Neuropathic pain

Contacts and locations

Locations

  • University of Michigan

    Ann Arbor, Michigan, 48109, United States

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