Zapping the brain after stroke may stop pain before it starts
NCT ID NCT07202455
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether a gentle electrical brain stimulation technique called tDCS, given alongside standard rehab, can prevent the development of chronic neuropathic pain after a stroke. Sixty adults who recently had a stroke will receive either real or sham tDCS for 10 sessions. Researchers will then check if they develop pain 6 months later.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- transcranial direct current stimulation (tDCS) device
- What this could lead to
- If it works, this could point toward a simple, non-drug way to prevent chronic pain after a stroke.
- What could go wrong
- This is a small, early-stage study (60 people) testing a prevention approach, so results may not apply widely. The treatment is non-invasive but may not be effective for everyone.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 60 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Jan 2026
An estimate. Start dates often move.
- Expected to finish
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Apr 2029
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Age ≥18 years * Ischemic or hemorrhagic stroke confirmed by MRI or scanner * Lesion(s) in somato-sensory areas (i.e. mainly in: the pons, thalamus, internal capsule, basal ganglia and operculo-insular regions) * Sensory and/or motor deficit requiring rehabilitation * Subacute stage (7 to 45 days post-stroke) * No neurological deficit or chronic neuropathic pain prior to stroke * No neuropathic pain at inclusion * Patient can be followed throughout the study. * Information letter read and understood * Able to give informed consent to participate in research * Affiliation with a social security scheme Exclusion Criteria: * Contraindication to tDCS (epilepsy/history of epilepsy, intracranial ferromagnetic material or implanted stimulator, acute eczema or irritated skin over the stimulation area) * Contraindication to MRI (use of a pacemaker or insulin pump, wearing of a metal prosthesis, intracerebral clip or piercing, claustrophobia) * Cognitive or language difficulties preventing comprehension of instructions and/or correct clinical assessment * Patients participating in another research protocol involving a drug in the 30 days prior to inclusion * Drug or psychoactive substance abuse * Pregnant or breast-feeding women * Patients under guardianship or curatorship, deprived of liberty, safeguard of justice * Major depression * Patients with Parkinson's disease * The presence of pre-existing lesions \>1.5 cm (maximum diameter) in a cerebral area belonging to the anatomically defined sensorimotor system * Alcohol abuse * Severe psychiatric disorders (e.g., schizophrenia) * Any tumor disease with a life expectancy of \<1 year * Increased intracranial pressure * Patients with a medical device containing electronics or conductive materials * Patients on continuous oxygen (system not adapted)
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
2 sites. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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CH Etienne Clémentel
Enval, 63530, France
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CHU Clemront-Ferrand
Clermont-Ferrand, France
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