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Brain scans aim to unlock secrets of spinal cord stimulation for chronic pain

NCT ID NCT03852381

Knowledge-focused Sponsor: University Health Network, Toronto Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at two types of spinal cord stimulation for people with long-term nerve pain after back surgery. One type causes a tingling sensation, while newer types do not. Researchers will use brain scans and pain questionnaires to figure out how each type works and which patients are most likely to benefit. The goal is to improve pain relief and reduce side effects.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Spinal cord stimulation device
What this could lead to
If successful, this could help doctors choose the best stimulation mode for each patient and improve long-term pain relief.
What could go wrong
This is an early-stage observational study with only 90 participants, so results may not apply to everyone. The main goal is understanding, not proving a new treatment works.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 90 people

The number the study aims to enrol. It can still change while the study runs.

Started

May 2019

Expected to finish

Dec 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 80 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Adults, 18 - 80 years of age, with refractory neuropathic pain (as per clinical features and DN4 score \> 3/10) in back and or lower limbs for more than 3 months following lumbar spine surgery 2. Severity of pain \> 3/10 on NRS and ODI score for disability \>40/100; and 3. Pain refractory to conventional medical management tried for at least 3 months. Exclusion Criteria: 1. Age \< 18 or age ≥ 80 years; 2. Previous trial or implantation of SCS system; 3. Procedural contraindications to SCS including extensive thoracolumbar spine surgery, moderate-to-severe central canal stenosis, coagulopathy, local or systemic infection; 4. Pregnancy; 5. Opioid dose \> 200 mg OMED; 6. Psychiatric or psychological disorder likely to impact perception of pain; 7. Inability to comply with the study interventions or evaluate treatment outcomes; 8. Mechanical spine instability as per flexion/extension lumbar X-rays; 9. Ongoing litigation issues related to the pain; and 10. Concomitant peripheral neuropathy or myopathy or central neuropathic pain (e.g. post-stroke pain).

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Conditions

The condition(s) this trial relates to.

Chronic Pain chronic pain syndrome neuralgia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Chronic pain Neuropathic pain

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Toronto Western Hospital

    RECRUITING

    Toronto, Ontario, M5T 2S8, Canada

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