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Which painkiller works best for frozen shoulder? new study aims to find out

NCT ID NCT07493226

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study is testing whether different types of NSAIDs (like ibuprofen, diclofenac, and meloxicam) work better for specific pain types in people with frozen shoulder. 120 adults with shoulder pain and stiffness will take one of these drugs along with home exercises for two weeks. The goal is to see which drug provides the best pain relief and improvement in movement, and whether the type of pain a person has affects which drug works best.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen, naproxen, etodolac, diclofenac, meloxicam, and lornoxicam
What this could lead to
If successful, this study could help doctors choose the most effective NSAID for each patient's specific pain type, improving pain relief and shoulder function.
What could go wrong
This is a small, early-stage trial with only 120 participants and a short 2-week follow-up. Results may not apply to all patients, and NSAIDs have known side effects like stomach upset.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 120 people

The number the study aims to enrol. It can still change while the study runs.

Started

Apr 2026

Expected to finish

Mar 2027

An estimate. End dates often move.

Lead sponsor

A government agency

The lead sponsor is a government body.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 75 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Being between 18-75 years of age 2. Having shoulder pain that has lasted for at least one month and being diagnosed with primary frozen shoulder 3. Having a VAS pain level ≥ 4/10 4. Having ≥30 degrees of range of motion restriction in at least two planes (flexion, abduction, or external rotation) 5. Not having any exclusion criteria and agreeing to participate in the study voluntarily Exclusion Criteria: 1. Patients with a history of shoulder trauma, those with musculoskeletal disorders characterized by pain and loss of function in the affected extremity (such as lateral epicondylitis, flexor tendon injury, de Quervein's tenosynovitis) 2. Presence of neurological involvement such as stroke, brachial plexus injury, Parkinson's disease, and cervical spine injury with or without radiculopathy 3. History of shoulder surgery, malignancy or tumor in the shoulder, those who have undergone shoulder manipulation 4. Presence of shoulder arthritis, rotator cuff tear or other shoulder injuries, thoracic outlet syndrome 5. Systemic disease affecting the shoulder region, severe degeneration or trauma (e.g., osteoarthritis, rheumatoid arthritis, history of labrum or articular cartilage injuries), inflammatory rheumatic diseases 6. Those who have received steroid injections into the affected extremity within the last 3 months, those using oral steroids or NSAIDs, those receiving any surgical or interventional treatment, or Planned individuals: 7. Those who are pregnant or lactating 8. Those with uncontrolled diabetes, heart failure, uncontrolled systemic disease (liver disease, chronic kidney failure, significant endocrine disorders, etc.) 9. Those with communication problems, severe psychiatric disorders 10. Those allergic to NSAIDs or with any contraindications 11. Those with bleeding, coagulation disorders, stomach ulcers, or symptomatic gastritis

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Conditions

The condition(s) this trial relates to.

bursitis frozen shoulder Motor Activity neuralgia Nociplastic Pain Shoulder Pain

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Konya Beyhekim Training and Research Hospital

    RECRUITING

    Konya, Selçuklu, 42000, Turkey (Türkiye)

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