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Could a Patient's own blood prevent chronic pain after back surgery?

NCT ID NCT05196503

Prevention Sponsor: University Hospital, Strasbourg, France Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

About 30% of people who have surgery for a herniated disc still suffer from nerve pain afterward. This study tests whether applying a gel made from the patient's own blood (platelet-rich fibrin) around the nerve during surgery can prevent that chronic pain. The trial will enroll 60 adults scheduled for disc surgery and measure their pain levels afterward.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
platelet-rich fibrin (PRF) made from the patient's own blood
What this could lead to
If it works, this could offer a simple, safe way to prevent long-term nerve pain after disc surgery, reducing the need for painkillers.
What could go wrong
This is a small early-phase trial with only 60 people, so results may not apply to everyone. The treatment might not reduce pain more than standard care.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

About 60 people

The number the study aims to enrol. It can still change while the study runs.

Started

Feb 2022

Expected to finish

Jan 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion criteria: * Patient, male or female, \>18 years old at the time of signing informed consent; * Patient for whom a diagnosis of radiculopathy on lumbar disc herniation has been made, and for whom surgery has been scheduled in the Neurosurgery department; * Patient affiliated to a social security health insurance scheme; * Patient able to understand the objectives and risks of research and to give informed, dated and signed consent; * Patient having been informed of the results of the prior medical examination; * Women of childbearing age provided that a negative blood pregnancy test is recorded at the inclusion visit and effective contraception used throughout the study. Exclusion criteria: * Patient with a history of lumbar spinal surgery (multiple herniated discs, herniated disc other than lumbar); * Patient with HIV, active cancer, HBV, HCV (verified by interview); * Patient on long-term systemic corticosteroid therapy; * Patient with an ASA score \> 3 during the consultation with the anesthesiologist; * Inability to give the patient informed information (patient in an emergency or life-threatening situation, difficulties in understanding); * Patient in exclusion period (determined by a previous or ongoing study); * Subject under safeguard of justice; * Subject under curatorship; * Pregnancy; * Breastfeeding.

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Conditions

The condition(s) this trial relates to.

neuralgia Pain, Postoperative radiculopathy

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Chronic postsurgical pain Neuropathic pain

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Les Hôpitaux Universitaires

    RECRUITING

    Strasbourg, Bas-Rhin, 67091, France

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