QUALITY OF LIFE

This study tests whether a natural substance called spermidine can improve heart and muscle health in people aged 65 and older with coronary artery disease. Participants take spermidine or a placebo for a period, and researchers measure changes in heart mass, muscle mass, inflamm…

This study tests a new, simpler laparoscopic surgery for women with pelvic organ prolapse (when pelvic organs drop from their normal position). The goal is to restore anatomy and improve quality of life while reducing risks from surgical mesh. About 60 women aged 30-80 with moder…

This study compares two surgical techniques for right-sided colon cancer: open surgery and laparoscopic (keyhole) surgery. The goal is to see if laparoscopic surgery leads to less pain, fewer complications, and faster recovery, while still being as effective at removing cancer. R…

This study looks at whether injecting special stem-like cells (Muse cells) directly into the ovaries can help women aged 28-70 going through perimenopause. The goal is to see if it safely stabilizes hormones, reduces symptoms like hot flashes and mood changes, and improves qualit…

This study tests a smartphone platform that uses artificial intelligence to help liver transplant patients manage their own care after surgery. About 133 adults who have received a liver transplant and can use a smartphone will take part. The goal is to see if the platform improv…

This study tests whether a planned two-step procedure for treating completely blocked heart arteries is safer and more effective than a single long procedure. About 200 adults with high-risk blockages will be enrolled. The approach aims to reduce complications and improve success…

This study explores whether a physical activity program can improve quality of life and reduce fatigue in children aged 8-18 with acute lymphoblastic leukemia who are on maintenance chemotherapy. Researchers will measure activity levels, sleep, and fatigue using surveys and activ…

This study looks at whether special movement exercises (perceptual-motor training) can help children with ADHD think better, move better, and feel better day-to-day. Thirty children aged 8 to 12 will take part. The goal is to see if these exercises improve cognitive functions, mo…

This study tests a new way of caring for children under 10 with diabetes. The clinic uses play, calmness training, healthy lifestyle advice, and parent support groups to improve quality of life for both kids and their families. About 100 children and their parents will take part …

This study looks at whether giving blood transfusions to anemic patients after they leave the intensive care unit (ICU) can help them feel less tired and recover better. About 346 adults who are ready to leave the ICU and have low hemoglobin will be randomly assigned to either st…

This study aimed to see if the Sana device could improve quality of life and reduce pain in people with fibromyalgia. It planned to compare the active device to a sham (fake) device in about 100 adults aged 18 to 65 who had fibromyalgia symptoms for at least 3 years. However, the…

This study aimed to see if using an immersive virtual reality headset for balance exercises is safe and practical for people with multiple sclerosis who experience dizziness and fatigue. The researchers planned to compare this new approach to standard vestibular therapy. However,…

This study tests whether focused ultrasound (MR-HIFU), alone or with standard radiation, can better relieve bone pain caused by cancer that has spread. About 216 adults with painful bone lesions will be randomly assigned to one of three groups. The goal is to see if adding ultras…

This study looks at whether a special education program before gallbladder removal surgery can improve patients' quality of life after the operation. About 200 adults aged 18 to 75 will take part. One group will get the usual hospital instructions, while the other will attend ext…

This study looks at whether a mobile app called Horizons can help adults who have chronic graft-versus-host disease after a stem cell transplant. About 20 people will use the app and answer surveys to see if it is practical and helpful. The goal is to improve their quality of lif…

This study aimed to see if practicing mindfulness breathing exercises could improve health and quality of life in adults with spinal cord injury. Researchers planned to measure heart rate, blood pressure, and metabolism changes. However, the study was withdrawn before enrolling a…

This study looks at whether giving advanced cancer patients $1000 each month for a year can reduce their financial stress and improve their quality of life. About 250 people with stage 3 or 4 cancer who are on Medicaid will take part. They will receive the monthly payments and fi…

This study tests a home-based digital literacy program for adults aged 65 and older. The goal is to help them better communicate with their healthcare team, manage their health information, and feel more socially connected. Twenty participants will learn to use digital tools in a…

This study tests a 12-week program called Breathe Easier+ for people who have finished treatment for non-small cell lung cancer and their partners. The program includes guided walking, resistance training, and meditation done at home using a tablet and Fitbit. The goal is to see …

This study tested whether an 8-week mobile app program, with education and phone counseling, could reduce symptom severity and improve quality of life and sleep in 82 menopausal women with urinary incontinence. The app was based on a health promotion model. Results may show that …

This study aimed to see if trazodone, a sleep aid, works better than quetiapine (an antipsychotic) or a placebo for treating delirium in adult surgical ICU patients. Delirium causes confusion, agitation, and sleep problems. The trial planned to measure how long delirium lasts, sl…

This study looks at whether recreational group drumming can improve the health of older adults living in the community. Researchers will measure changes in quality of life, depression, sleep, and blood pressure in 300 participants aged 60 and above. The goal is to see if drumming…

This study looks at whether a regular 8-week exercise program can improve physical fitness and quality of life for paramedic students. About 60 students will be randomly assigned to either the exercise group or a control group. Researchers will measure changes in endurance, stren…

This study compares two treatments for early-stage oropharyngeal (throat) cancer: robotic surgery or radiation therapy. The goal is to see which approach leads to better swallowing function and overall quality of life. About 138 patients will be randomly assigned to one of the tw…

This study compares two types of weight-loss surgery—sleeve gastrectomy alone versus sleeve gastrectomy with transit bipartition—to see which leads to fewer digestive issues (dumping syndrome) and better quality of life. About 200 adults with obesity will be followed for 6 months…

This study tests whether watching 10-minute virtual reality nature videos twice a week for 12 weeks can improve quality of life, mood, and agitation in nursing home residents with dementia. Sixty participants will either receive the virtual nature sessions plus usual care, or usu…

This study looks at whether teaching people how to care for their mouth and teeth can improve oral health, sleep, and overall quality of life for those using a non-invasive breathing machine at home. About 30 adults will be split into two groups: one gets special oral care educat…

This study tests whether a 12-week exercise program (aerobic and strength training) helps people recover after heart surgery, such as valve replacement or bypass. 76 adults will be split into two groups: one does the program, the other gets usual care. Researchers will measure qu…

This study tests an online self-help program called Together After Cancer for breast cancer survivors and their intimate partners. The program includes brief coach calls and aims to improve the survivor's quality of life and the couple's relationship satisfaction. About 480 coupl…

This study tests a program called Bright IDEAS that teaches problem-solving skills to parents of children receiving palliative care. The goal is to see if it reduces parents' stress, anxiety, and depression compared to standard support. About 40 parents will take part in 6-8 sess…

This study looks at whether a 30-minute education session with a radiation therapist can help breast cancer patients feel less anxious and more in control during their radiation treatment. About 109 patients will be randomly assigned to either receive this extra session or standa…

This study looks at whether a group-based program called Horizons can help adults with chronic graft-versus-host disease (cGVHD) improve their quality of life and coping skills. About 20 people who had a stem cell transplant and now have moderate to severe cGVHD will take part. T…

This study tests a special program called Horizons for adults who have had a stem cell transplant and developed chronic graft-versus-host disease (GVHD). The program includes group sessions to help patients cope with symptoms, improve quality of life, and take their medications a…

This study aimed to see if a food supplement called ARACOMPLEX could help maintain quality of life in patients with advanced or metastatic pancreatic cancer who are receiving chemotherapy. The supplement contains maca extract, vitamins, and minerals. The study was withdrawn befor…

This study tests a video game designed to teach self-advocacy skills to women with advanced cancer. The game lets players make decisions for characters facing similar challenges, helping them learn to communicate better with doctors and manage symptoms. The goal is to improve qua…

This study looks at how invasive breast cancer and its treatments impact the quality of life of 133 patients in Martinique. Researchers will use surveys to understand patients' physical, emotional, and daily challenges, as well as how long treatment takes. The goal is to find way…

This study tests whether measuring parathyroid hormone during thyroid removal surgery can help doctors personalize care afterward. 150 adults having their thyroid removed will be split into groups based on their hormone drop. Some will skip routine blood tests, others will get ea…

This study interviews 20 people aged 16-25 who have had urinary problems since childhood and are moving from pediatric to adult urology care. The goal is to learn about their experiences and challenges during this transition. Findings will help doctors improve care for other youn…

This study looks at whether a community wellness program at Bonton Farms can improve heart health and quality of life for 300 adults in the Bonton neighborhood. Participants choose their own activities, and researchers track changes in diet, exercise, sleep, and other health meas…

This study follows 384 adults in Brazil who are using cannabis-based products prescribed by their doctors for chronic pain, anxiety, or depression. Researchers will not provide the medication but will track patients for 6 months through online surveys to measure changes in qualit…

This study tests a web-based decision aid and planning tool for female cancer survivors who want to have children in the future. About 260 participants aged 18 to 45 who have completed cancer treatment will use the tool to help them make informed choices about family building. Th…

This study looks at how spasmodic dysphonia, a condition that causes uncontrollable voice spasms, affects patients' jobs and social lives. Researchers will interview 20 adults who have received botulinum toxin injections to understand the condition's impact and whether treatment …

This study looks at whether adding community health worker visits and free healthy groceries to the standard Meals on Wheels program can improve diet, reduce loneliness, and boost quality of life for older adults in Rhode Island. About 1,640 participants at high nutritional risk …

This study looks at whether stereotactic radiosurgery (a precise type of radiation) for brain tumors causes thinking or memory problems. About 80 adults with brain metastases or benign meningiomas will take memory tests and quality-of-life surveys before and after treatment. Rese…

This study tests whether proactive telemedicine (brief remote coaching on habits like smoking, diet, and exercise) works as well as in-person visits for rural adults who haven't seen their primary care team in over a year. About 120 participants will be randomly assigned to eithe…

This study will collect data from up to 300,000 adults who use a digital physical activity program called Sword Move. The goal is to observe how increasing physical activity affects overall health, quality of life, and mental well-being. Participants are healthy or have stable co…