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Could a drug combo during surgery speed up recovery?

NCT ID NCT06884540

Symptom relief Sponsor: CHU de Quebec-Universite Laval Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jul 02, 2026 · Updated 4 times

Summary

This pilot study tests whether giving dexmedetomidine and lidocaine during major non-cardiac surgery can help patients recover faster and with less pain. About 100 adults having elective surgery will be randomly assigned to receive one of these drugs or standard care. The main goal is to see if a larger trial is possible, not yet to prove the drugs work.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
dexmedetomidine and lidocaine
What this could lead to
If this works, it could lead to a simple way to improve recovery after major surgery and reduce reliance on opioids.
What could go wrong
This is a small pilot study testing feasibility, not effectiveness. The drugs may not improve outcomes or could cause side effects like low blood pressure.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 100 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jul 2025

Expected to finish

Oct 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Adults \>/= 18 years. 2. Having elective major non-cardiac surgery (i.e., planned duration \>/= 1.5 hours and anticipated \>/= 1 night hospital stay). 3. Requiring general anesthesia. 4. Able to complete baseline quality of recovery assessment. Exclusion Criteria: 1. Individuals with known contraindications to dexmedetomidine or lidocaine (e.g., allergy to alpha-2 agonists or local anesthetics, severe renal or hepatic failure, bradycardia or hypotension), as per routine assessment. 2. Regular use of alpha-2 agonists or local anesthetics prior to hospitalization. 3. Pregnant women. 4. Planned use of regional analgesia (i.e., epidural, peripheral nerve block, trunk nerve block) in conjunction with general anesthesia. Local anesthetics such as lidocaine are administered as part of regional analgesia technique. Combination with intravenous lidocaine is contraindicated to avoid exceeding therapeutic concentration. 5. Neurosurgical procedures except for spine surgery. 6. Planned postoperative intubation after PACU discharge. 7. No fixed address.

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Conditions

The condition(s) this trial relates to.

Pain, Postoperative

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Anesthesia Anesthesia complication Anesthesia morbidity Feasibility studies Pain, postoperative Patient-centredness Quality of life Surgery

Contacts and locations

Locations

  • CHU de Québec-Université Laval (Hôpital de l'Enfant-Jésus)

    Québec, Quebec, G1J 1Z4, Canada

  • CISSS de Chaudière-Appalaches (Hôtel-Dieu de Lévis)

    Lévis, Quebec, G6V3Z1, Canada

  • Centre hospitalier de l'Université de Montréal (CHUM)

    Montreal, Quebec, H2X 0C1, Canada

  • Mount Sinai Hospital

    Toronto, Ontario, M5G 1X5, Canada

  • Royal Columbian Hospital

    New Westminster, British Columbia, V3L 0A2, Canada

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