Blood transfusions after ICU: a new hope for tired survivors?
NCT ID NCT04591574
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looks at whether giving blood transfusions to patients who are anemic after leaving the intensive care unit (ICU) can help them feel less tired and recover better. About 346 adults from UK hospitals will be randomly assigned to either the usual care (transfusions only if very needed) or a more active transfusion plan. The goal is to see if treating anemia more aggressively improves quality of life and physical function over six months.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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346 people
The number who actually took part.
- Started
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Sep 2020
- Expected to finish
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May 2026
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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16 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Patient who received level 3 ICU care at any time point during the current hospital admission (defined as advance respiratory support and/or at least two organ support). * Patient considered ready for discharge from ICU by the caring clinical team. * Hb less than or equal to 94g/L when ready for ICU discharge or during the first seven days following the decision by the treating clinician that the patient is ready for ICU discharge. * 16years of age or older * Patient expected to remain in study hospital until hospital discharge. * Consent provided (by participant or in accordance with appropriate mental capacity legislation for the site). Exclusion Criteria: * Contraindication or objection to RBC transfusion * Active bleeding when screened * Primary neurological ICU admission diagnosis * Patients discharged from the ICU following cardiac surgery * Currently receiving or planned to receive end-of-life care * Not expected by clinical team to survive to hospital discharge * Patient with a proven chronic haematological disease that requires regular RBC transfusion to treat anaemia * Patient with dialysis-dependent chronic renal failure prior to ICU admission * Patient receiving regular erythropoietin (or any erythropoiesis stimulating agent) treatment for anaemia prior to ICU admission * Unable to obtain consent (frompatietn or in accordance with appropriate mental capacity legislation for the site) * Readmission to ICU during current hospitalisation episode and not enrolled following previous ICU admissions * Patient recovering following liver transplantation, kidney transplantation, or combined kidney/pancreas transplantation * Patient recovering from variceal bleeding due to chronic liver disease * Prisoners * Patient due for imminent hospital discharge within the next 24 hours
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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NHS Lothian
Edinburgh, United Kingdom
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