TUMOR

This study tests whether two drugs, pembrolizumab and lenvatinib, can shrink brain tumors in people with breast cancer, lung cancer, or other solid tumors that have spread to the brain. About 104 participants will receive the combination treatment. The main goal is to see how man…

This early-phase study tests the safety of a drug called nab-sirolimus in adults with advanced solid tumors who also have moderate liver impairment. About 28 participants will receive the drug to see how their bodies process it and what side effects occur. The goal is to find the…

This study tests an investigational drug called nirogacestat in about 40 adults with desmoid tumors (also called aggressive fibromatosis). The goal is to see how safe the drug is and what effects it has. Participants will take the drug and be monitored for side effects and tumor …

This study tests a treatment plan for people with a type of muscle-invasive bladder cancer that has unusual cells (variant histology). Participants first receive chemotherapy with or without immunotherapy, then a combination of radiation and low-dose chemo to try to save the blad…

This study tests a combination of two drugs, nab-sirolimus and letrozole, in people with advanced or recurrent endometrioid endometrial cancer. The goal is to see if the combination can shrink or control tumors. About 29 participants will receive the treatment, and researchers wi…

This study tests a special PET/CT scan using a new tracer called [68Ga]Ga-NI-FAPI-04 to better see diseases linked to fibroblast activation, such as tumors, heart problems, lung scarring, and immune conditions. About 30 adults, including healthy volunteers, will get the scan to s…

This study tests a new type of PET scan (68Ga-NK224) to measure PD-L1 levels in tumors. PD-L1 is a protein that helps some cancers hide from the immune system. The goal is to see if the scan can give the same information as a tissue biopsy, but without the need for surgery. The s…

This study will collect images and videos from 10,000 patients who undergo capsule endoscopy (a pill-sized camera that takes pictures of the digestive tract). Researchers will use this data to train artificial intelligence to detect bowel diseases like Crohn's, celiac disease, an…

This study tests a new radioactive tracer called 68Ga-FXX489 (NNS309) that helps PET/CT scans find tumors and cancer spread. About 30 adults with suspected cancer will receive the tracer and be scanned to see how well it lights up tumors and how safe it is. The goal is to improve…

This study aims to understand why some cancer patients develop heart problems after receiving immune checkpoint inhibitors (a type of immunotherapy). Researchers will analyze blood samples and genetic factors from 1,200 adults starting this treatment. The goal is to find ways to …

This study tests an artificial intelligence tool that helps doctors spot blood vessels during certain endoscopic procedures. The goal is to reduce the risk of bleeding or accidental punctures. About 20 people with achalasia or tumors will take part. The AI works in real time to h…

This study is a large registry that will follow 8,000 cancer patients who receive radiation therapy guided by an MR-Linac, a machine that combines an MRI scanner with a radiation beam. The goal is to see if this technology helps people live longer, controls tumors better, and imp…

This early study tests a new device called the CIPHER System in 10 adults having surgery for a newly diagnosed brain tumor (glioma). The device is used during the operation to record brain signals from the tumor and surrounding areas. The main goal is to check if the device is sa…