TUMOR

This early-phase study tests whether combining pembrolizumab and lenvatinib can help control advanced pancreatic cancer that has not responded to prior treatment. Fifteen adults with metastatic pancreatic ductal adenocarcinoma will receive the drug combination. The goal is to see…

This study compares two treatments for advanced head and neck cancer: the immunotherapy drug pembrolizumab (Keytruda) plus radiation versus standard chemotherapy (cisplatin) plus radiation. About 126 participants with p16-positive cancer will be enrolled. The goal is to see if th…

This study tests a new device that uses focused ultrasound (histotripsy) to break apart kidney tumors without any cuts or needles. About 67 adults with a single small kidney tumor (3 cm or less) will receive this non-invasive treatment. The goal is to see if the tumor is complete…

This early-phase study tested the safety and tolerability of an experimental drug called AZD6244, given as a capsule, in 58 people with advanced solid tumors that had stopped responding to standard treatments. The main goal was to identify side effects and determine how the drug …

This early-phase study tests a new cell therapy (NW-301VT) for people with advanced solid tumors that have a specific KRAS mutation and a certain immune type (HLA-A*11:01). The therapy uses the patient's own T cells, which are genetically modified to recognize and attack cancer c…

This early-phase study tests a new treatment called OBX-115, which uses a patient's own tumor-fighting immune cells that have been modified in the lab to include a protein (IL15) to help them survive longer. These cells are given along with acetazolamide to adults with metastatic…

This study tests whether combining two drugs, obinutuzumab and CC-99282, can control follicular lymphoma that has a high tumor burden and has not been treated before. About 33 adults with stage II–IV disease will receive the combination and be monitored for side effects and respo…

This study tests whether focused ultrasound (MR-HIFU), alone or with standard radiation, can better relieve bone pain caused by cancer that has spread. About 216 adults with painful bone lesions will be randomly assigned to one of three groups. The goal is to see if adding ultras…

This study tests new MRI guidance software (Philips iSuite) to see if it helps doctors place needles more quickly and accurately during biopsies and tumor ablations. About 12 people already scheduled for an MRI-guided procedure will take part. The goal is to compare this new soft…

This study tracks 1,000 children with tumors who receive proton therapy to see how safe it is. Researchers will record any serious side effects that may be linked to the radiation. The goal is to better understand the risks of this precise type of radiation in young patients.

This study collects blood and urine samples from 1,000 adults who are getting radiation therapy for cancer. Researchers want to see how radiation changes genes in white blood cells, damages red blood cells, and alters hormone levels. Samples are taken before, during, and after tr…