BREAST CANCER

This phase III trial tests whether a personalized, high-dose chemotherapy followed by stem cell rescue can improve cure rates for people with high-risk, BRCA1-like breast cancer. The study includes 174 participants with stage III, HER2-negative tumors. The goal is to see if this …

This early-phase study tests a vaccine made from cancer-related peptides (protein pieces) to see if it is safe for people with ER-positive breast cancer. The vaccine is given after standard treatments like chemotherapy and is designed to train the immune system to recognize and a…

This early-stage trial tests whether a DNA vaccine targeting mammaglobin-A (a protein found on breast cancer cells) is safe and can boost the immune system against cancer. About 27 women with ER+, HER2- breast cancer will receive the vaccine while undergoing standard hormone ther…

This early-phase study tests a cancer vaccine (PVX-410) alone or with an immunotherapy drug (durvalumab) in 22 women with stage II or III triple negative breast cancer who have completed standard treatment. The goal is to see if the vaccine is safe and can boost the immune system…

This study tests a new drug, gedatolisib, combined with standard treatments (fulvestrant with or without palbociclib) in about 700 people with HR-positive, HER2-negative advanced breast cancer that has worsened after prior therapy. The goal is to see if the new combination helps …

This study tests a highly targeted radiation technique called stereotactic partial breast irradiation (S-PBI) for women with early-stage breast cancer. The treatment uses a special device (GammaPod) to deliver radiation in just 5 sessions, aiming to kill cancer cells while sparin…

This early-phase study tests the safety of combining a cancer vaccine (DPX-Survivac) with hormone therapy, and sometimes radiation or chemotherapy, before surgery in people with HR+HER2- breast cancer. The goal is to see if these combinations are safe and do not delay planned sur…

This study tests whether combining anastrozole and palbociclib can safely control hormone receptor-positive, HER2-negative metastatic breast cancer in postmenopausal women. About 40 participants will receive the drugs either as their first treatment or after initial chemotherapy.…

This study tests a combination of three drugs (atezolizumab, trastuzumab, and vinorelbine) in people with advanced HER2-positive breast cancer that has not responded to prior treatments. The goal is to see if this mix can shrink tumors better than current options, especially in c…

This early-phase study tests a new oral drug, inavolisib, in people with advanced solid tumors or breast cancer that have a specific genetic change (PIK3CA mutation). The goal is to find safe doses and see how the drug works alone or combined with standard hormone therapies and t…

This study tests an experimental drug called entrectinib in people with advanced solid tumors that have certain gene changes (NTRK, ROS1, or ALK). The drug aims to shrink or control the cancer by blocking signals that help it grow. About 534 adults with various cancers, including…

This study tests a new drug called PF-07104091, alone or with other medicines, in people with advanced breast, lung, or ovarian cancer that has spread or come back. The goal is to find a safe dose and see if it shrinks tumors. About 157 adults will take part, and the drug is give…

This study tests a one-week course of radiation for breast cancer patients who need treatment to the chest or breast and nearby lymph nodes. The goal is to see if this shorter approach is safe and effective at controlling the disease. About 197 participants will be followed for a…

This study tests a combination of two drugs, olaparib and sapacitabine, in people with advanced breast cancer that has a BRCA gene mutation. The goal is to find the safest dose and see if the drugs shrink tumors. About 10 participants will take part in this early-phase trial.

This study looks at whether using ultrasound before surgery can help identify breast cancer patients who have only a few affected lymph nodes, allowing them to avoid a more extensive lymph node removal called ALND. The study includes 78 adults with early-stage, hormone receptor-p…

This study tests whether a nurse-led program can help women aged 45-64 in Hong Kong better manage their health and use medical resources wisely. Over 1,700 participants will either receive personalized nurse guidance or general health advice. The goal is to improve health confide…

This study looks at how well proton therapy works for treating early-stage breast cancer in people aged 40 and older. The goal is to see if this focused radiation can keep the cancer from coming back while causing fewer side effects. About 150 participants who had a lumpectomy wi…

This study looks at whether a 16-week exercise program can reduce inflammation in fat tissue for women who have finished treatment for early-stage breast cancer. About 100 participants will take part to see if movement helps lower markers linked to cancer recurrence. The goal is …

This study tests whether closely monitoring for early signs of arm swelling (lymphedema) after breast cancer surgery can prevent it from becoming a long-term problem. 250 women who had lymph nodes removed will be randomly assigned to either a surveillance program with immediate t…

This study tests whether adding alpelisib to standard hormone therapy (fulvestrant) helps control advanced breast cancer in people with a PIK3CA gene mutation. It includes 234 men and postmenopausal women whose cancer worsened after prior treatments. The goal is to see if the com…

This study looks at whether the number of immune cells in and around a triple-negative breast cancer tumor can help doctors choose the best chemotherapy and immunotherapy before surgery. About 139 women with early-stage breast cancer will receive treatment tailored to their immun…

This study tests whether giving the drug pembrolizumab along with targeted radiation before standard surgery or chemotherapy is safe and helps the immune system fight breast cancer. About 66 people with operable breast cancer will receive two doses of pembrolizumab, with radiatio…

This early-stage study tests a new drug called GNC-035 in people with advanced breast cancer that has spread or cannot be removed by surgery. The main goals are to check the drug's safety, find the best dose, and see if it can shrink tumors. About 36 adults will take part.

This study tests a combination of two drugs—sacituzumab govitecan and talazoparib—in people with metastatic triple-negative breast cancer that has spread. The goal is to see if the combo can shrink tumors and help patients live longer. About 75 adults with advanced disease are ta…

This study tested whether adding a 2-year course of palbociclib to standard hormone therapy (given for at least 5 years) helps prevent breast cancer from returning in people with HR+/HER2- early breast cancer. About 5,800 participants with stage II or III cancer took part. The ma…

This study is for older adults with HER2-positive breast cancer, a type that has too much of a protein called HER2. The trial tests a drug called T-DM1, which combines a targeted antibody with chemotherapy to kill cancer cells. The goal is to see if giving T-DM1 after surgery hel…

This study looks at whether giving an extra dose of radiation (16Gy) to the tumor area after standard whole-breast radiation (50Gy) helps prevent breast cancer from coming back in women with ductal carcinoma in situ (DCIS). About 2004 women who had breast-conserving surgery took …

This study tests a new drug called ST101 in people with advanced solid tumors that cannot be removed by surgery or have spread. The goal is to find a safe dose and see if the drug can shrink tumors. About 125 adults with cancers like glioblastoma, melanoma, breast, or prostate ca…

This study tests whether adding the immunotherapy drug durvalumab to two standard targeted drugs (trastuzumab and pertuzumab) can shrink tumors more effectively in people with a specific, aggressive type of breast cancer called HER2-enriched. About 51 women with this cancer will …

This study looks at whether the beta-blocker carvedilol can prevent or treat heart problems in breast cancer patients receiving HER2-targeted therapy. About 184 adults with HER2-positive breast cancer will be randomly assigned to take carvedilol either preventatively or only afte…

This study tests a drug called pacritinib in people with advanced solid tumors (like breast cancer) that have a specific genetic change called 1q21.3 amplification. The goal is to see if the drug can shrink tumors or slow their growth. About 74 adults whose cancer has not respond…

This study looks at whether people with HER2-positive metastatic breast cancer who have done very well on anti-HER2 therapy (cancer controlled for 3+ years) can safely stop that treatment. Researchers will monitor those who stop versus those who continue to see if the cancer stay…

This study tested whether adding the drug abemaciclib to standard hormone therapy helps prevent breast cancer from returning in people with a high-risk, early-stage type of breast cancer (HR+, HER2-). Over 5,600 participants who had surgery and had cancer in their lymph nodes too…

This study compares two chemotherapy regimens for people with non-triple negative breast cancer who have had surgery. One group gets a standard four-drug sequence, while the other gets a different two-drug combination. The goal is to see which approach better prevents cancer from…

This study looks at whether giving extra radiation to the internal mammary lymph nodes can help prevent breast cancer from coming back in high-risk patients. About 2,400 people who had a mastectomy or breast-conserving surgery with positive lymph nodes are taking part. The goal i…

This study looks at whether women with early-stage HER2-positive breast cancer who have a complete response to initial chemotherapy and HER2-targeted therapy can safely receive only 6 months of further HER2-targeted treatment instead of the usual 12 months. The goal is to reduce …

This study tests two drugs, niraparib and dostarlimab, given before surgery to people with BRCA or PALB2 gene mutations and early-stage breast cancer. The goal is to see if the treatment shrinks tumors and boosts immune activity. 62 participants are enrolled, and the study is act…

This study tests whether adding a new drug called inavolisib to two standard treatments (palbociclib and fulvestrant) can help people with a certain type of advanced breast cancer live longer without their disease getting worse. The cancer must have a specific gene mutation (PIK3…

This study tests a drug called Trastuzumab-Deruxtecan (T-DXd) in 28 people with HER2-low breast cancer that has spread to the brain. The goal is to see if the drug can shrink brain tumors and tumors elsewhere in the body. Participants receive the drug intravenously, and doctors m…

This study tests a new medicine called vepdegestrant combined with palbociclib against the standard treatment (letrozole plus palbociclib) for people with advanced ER+/HER2- breast cancer that cannot be cured by surgery. Participants must not have received any prior cancer treatm…

This study offers ongoing treatment with ruxolitinib (alone or with other cancer therapy) to people with pancreatic, colorectal, breast, or lung cancer who were already benefiting from it in a previous Incyte study. It includes up to 10 participants and focuses on tracking side e…

This study tests a new drug, DS-8201a, against standard treatments for people with a specific type of advanced breast cancer called HER2-low. The cancer has spread or cannot be removed by surgery, and prior treatments have stopped working. The goal is to see if the new drug can s…

This study tests whether adding the immunotherapy drug nivolumab to standard chemotherapy (carboplatin) helps people with metastatic triple-negative breast cancer live longer without their disease getting worse. About 78 participants with advanced cancer that has spread will rece…

This study tests an experimental drug called QBS72S in 21 adults with advanced breast or lung cancer that has spread to the brain. The goal is to see if the drug can shrink or control brain tumors. Participants receive the drug and are monitored for side effects and tumor respons…

This study tests giving radiation therapy before surgery to women with early-stage, hormone-positive breast cancer. The goal is to find a safe dose and see how the tumor responds. 15 women aged 50 or older with small tumors and no lymph node spread are participating.

This study tested whether adding the drug vorinostat to standard chemotherapy (carboplatin and nab-paclitaxel) before surgery could improve outcomes for women with HER2-negative breast cancer. About 68 participants received either the chemo combo with vorinostat or a placebo. The…

This study looks at whether aerobic exercise can lower ctDNA levels in the blood, which may help prevent cancer from returning. About 33 people who have been treated for high-risk breast, prostate, or colorectal cancer will try different amounts of weekly exercise to find the saf…

This early-stage trial tests the safety of combining two drugs, olaparib and vorinostat, in people with advanced breast cancer that has returned or spread. The study includes 28 adults whose cancer is not HER2-positive. The goal is to find the best dose and check for side effects…

This study tests a program called WeCan-Rural for breast cancer survivors living in rural areas. The program aims to help them eat better, be more active, and manage their weight to lower their risk of heart disease. About 40 women who finished cancer treatment in the last 5 year…

This study looks at whether adding surgery or radiation to standard chemotherapy or hormone therapy can help control breast cancer that has spread to 1-3 spots in the bones. The goal is to see if this combined approach keeps the cancer from growing or spreading longer than standa…

This phase 3 study compares a new drug, Dato-DXd, with standard chemotherapy in 732 people whose HR-positive, HER2-negative breast cancer has spread and is no longer responding to hormone therapy. Participants have had one or two prior chemotherapies. The goal is to see if Dato-D…

This study looks at the safety of the drug TALZENNA in adults with a specific inherited breast cancer (BRCA mutation-positive, HER2-negative) that cannot be removed by surgery or has come back after chemotherapy. Only 3 participants who have not taken TALZENNA before will receive…

This early-phase study tests an experimental drug called MOMA-313, given alone or with another drug (olaparib), in people with advanced solid tumors that have a specific DNA repair problem (HR deficiency). The main goals are to check safety, find the best dose, and see if the dru…

This study looks at whether women aged 50 and older with a very low-risk type of early breast cancer (DCIS) can avoid radiation therapy after lumpectomy. The goal is to see if the cancer stays away without radiation, reducing unnecessary treatment and side effects. About 295 part…

This study compares two types of radiation therapy for people with breast cancer that hasn't spread. The goal is to see if proton therapy is better than standard photon therapy at reducing heart problems while still controlling the cancer. Over 1,200 participants were randomly as…

This study tested a shorter course of radiation (hypofractionation) for women with breast cancer that has spread to lymph nodes. The goal was to see if this approach reduces long-term side effects like arm swelling (lymphedema) while still controlling cancer. About 137 women part…

This study looks at the long-term safety of a drug called TOL2506 in people with a type of breast cancer that is fueled by hormones. It includes premenopausal women and men who have already finished a previous study. Participants will continue taking TOL2506 along with other horm…

This study tests giving a short course of radiation to the breast tumor before surgery, using MRI for precise targeting. The goal is to treat a smaller area of breast tissue and reduce side effects. About 39 women with early-stage breast cancer will receive radiation, then have s…

This study tests a drug called ribociclib combined with standard hormone therapy for people with ER-positive breast cancer. The goal is to see if the combination can clear tumor DNA from the blood and help control the disease. About 120 postmenopausal women with early-stage cance…

This study tests if a very low-carb (ketogenic) diet, a low-carb diet, or the diabetes drug canagliflozin can prevent high blood sugar caused by the cancer drug alpelisib. The goal is to see if controlling blood sugar helps alpelisib work better for people with metastatic PIK3CA-…

This study tests whether adding the drug pyrotinib to standard chemotherapy before surgery can completely eliminate cancer in women with HER2-positive early breast cancer. About 113 women will receive the treatment and then have surgery to see if no cancer remains. The goal is to…

This study tests a less intense chemotherapy combination for people with early-stage HER2-positive breast cancer. The goal is to see if a milder regimen (paclitaxel, trastuzumab, and pertuzumab) can clear the cancer before surgery as effectively as the standard stronger regimen, …

This study tests whether a web application can help breast cancer patients better follow their hormone therapy and improve their quality of life. About 438 patients starting hormone therapy after breast cancer treatment will use the app or receive standard care. The main goal is …

This early-stage study tests an experimental drug called AZD6244 combined with standard chemotherapies in 140 people with advanced solid tumors (breast, colon, lung, melanoma, kidney). The main goal is to find a safe dose and see how the body handles the drugs. Participants must …

This phase 3 study tests whether a new drug, DS-8201a, works better than the current standard T-DM1 for people with advanced HER2-positive breast cancer that has spread or cannot be removed. About 524 adults who have already tried trastuzumab and taxane will receive one of the tw…

This early-stage study tests an experimental pill, ATV-1601, in people with advanced solid tumors (including certain breast, ovarian, and prostate cancers) that have a specific AKT1 gene mutation. The main goals are to check the drug's safety, find the best dose, and see how the …

This study tests a new drug, Dato-DXd, against standard chemotherapy for people with advanced triple-negative breast cancer who cannot receive immunotherapy. About 644 participants will be randomly assigned to receive either Dato-DXd or one of several chemotherapy options. The go…

This study looks at whether a procedure to collect and freeze eggs or embryos before chemotherapy can help preserve fertility in women under 40 with breast cancer. The approach combines hormone stimulation with tamoxifen to avoid delaying cancer treatment. The main goal is to see…

This study tested two different chemotherapy regimens, given before surgery, to see which works better for stage II-III breast cancer. Some participants also received trastuzumab, a targeted therapy. The main goal was to see if the tumor disappeared completely by the time of surg…

This study looks at whether giving radiation only to the area where the cancer was removed (partial breast irradiation) is safe and effective for women with early-stage breast cancer. Instead of 5-7 weeks of whole-breast radiation, participants receive 2 weeks of daily treatments…

This study tests two oral medicines, vepdegestrant and samuraciclib, taken daily at home by adults with advanced or metastatic ER+ breast cancer that no longer responds to prior treatments. The goal is to see if the combination is safe and can shrink tumors or slow cancer growth.…

This study aimed to see if the drug capivasertib could clear cancer DNA from the blood of 20 women with ER-positive breast cancer who were already on hormone therapy. The goal was to prevent the cancer from coming back or spreading. However, the study was withdrawn before any par…

This study tested whether a higher dose (500 mg) of the hormone therapy fulvestrant works better than the standard dose (250 mg) in postmenopausal women with advanced breast cancer that had worsened after previous hormone treatments. The trial involved 736 participants and measur…

This early-phase trial tests a single, high dose of radiation given before surgery for early-stage breast cancer. The goal is to find the highest safe dose that can destroy the tumor in one session, potentially shortening treatment from weeks to one day. The study involves 45 wom…

This study tested whether a shorter, higher-dose radiation schedule (given over 3 weeks) works as well as the standard longer schedule (over 5 weeks) for women with early-stage breast cancer after lumpectomy. Over 2,300 women participated. The goal was to see if the shorter cours…

This study compares two surgical methods (Grisotti flap and reverse mirror Grisotti flap) for women with early-stage breast cancer located in or near the nipple-areola area. The goal is to see which technique leads to better flap survival and cosmetic results. 106 women aged 25-7…

This study tests the drug Lonsurf in people with metastatic breast cancer that has spread. It aims to see if the drug can stop or slow cancer growth. About 86 adults will take part, and the main goal is to measure how long the cancer stays under control.

This early-phase study tests a new drug, AC699, in about 100 people with a common type of advanced breast cancer (ER+/HER2-). The main goals are to find a safe dose and check for side effects. Researchers will also look for signs that the drug can shrink tumors or slow the cancer…

This study tests a new drug called onvansertib combined with standard chemotherapy (paclitaxel) in people with triple-negative breast cancer that has spread to other parts of the body. About 50 adults with advanced disease are participating to see if the combination is safe and c…

This study tests whether a special coated mesh can lower the risk of implant shifting or poking through the skin after breast reconstruction. One hundred women with breast cancer will receive the mesh along with a breast implant in a single surgery. The goal is to see if this app…

This study compares a new drug, HS627, against an existing one, pertuzumab, when both are given with trastuzumab and chemotherapy before surgery for early or locally advanced HER2-positive breast cancer. The main goal is to see if HS627 can eliminate all signs of cancer in breast…

This study tests whether combining two drugs—atezolizumab (an immunotherapy) and tivozanib (a targeted therapy)—can shrink tumors in cancers that typically don't respond to immunotherapy alone. About 29 adults with advanced bile duct, gallbladder, breast, neuroendocrine, ovarian,…

This study tested a combination of drugs (avelumab, palbociclib, and hormone therapy) given before surgery to people with early-stage, hormone-sensitive breast cancer. The goal was to see if the treatment could shrink or eliminate tumors. 33 participants received the drugs for ab…

This study looks at women having breast reconstruction after mastectomy. It compares two methods: one using a special material called acellular dermal matrix (ADM) and one without it. The goal is to see which method leads to fewer problems like infections or the need for more sur…

This study tests a combination of three drugs (nivolumab, bicalutamide, and ipilimumab) to control metastatic HER2-negative breast cancer without using chemotherapy. The goal is to see if this approach can shrink tumors or keep them stable for at least 24 weeks. The trial involve…

This study tests whether adding the drug palbociclib to standard hormone therapy before surgery can shrink tumors in people with early-stage hormone receptor-positive, HER2-negative breast cancer. About 51 participants will receive the combination for several months before their …

This study compares two radiation schedules for women with early-stage breast cancer: the standard 3-week course versus a shorter 2-week course. About 400 women took part to see if the shorter treatment is as safe and effective at controlling cancer and reducing side effects. The…

This study tests two oral medications, vepdegestrant and PF-07220060, in people with advanced or metastatic ER+/HER2- breast cancer that has stopped responding to prior treatments. The goal is to see if the combination is safe and can shrink tumors. Participants take the pills at…

This study tests a combination of chemotherapy (Taxotere) and a targeted drug (trastuzumab) given before surgery to shrink tumors in Nigerian women with HER2-positive breast cancer. The main goal is to see how many women have no cancer cells left in the breast or lymph nodes at t…

This study tests whether adding the immunotherapy drug atezolizumab to the targeted therapy trastuzumab emtansine (T-DM1) can prevent breast cancer from returning in people with HER2-positive breast cancer who still have cancer cells after initial treatment and surgery. About 1,1…

This study tests whether a newer drug, margetuximab, works better than the standard trastuzumab when combined with chemotherapy and pertuzumab before surgery for stage II-III HER2-positive breast cancer. About 174 participants will receive one of the two combinations. The main go…

This study tests whether giving two drugs (sacituzumab govitecan and pembrolizumab) before surgery can help control early-stage triple-negative breast cancer that hasn't responded well to standard chemotherapy and immunotherapy. About 27 adults with this type of breast cancer wil…

This study tests whether a new combination of drugs (datopotamab deruxtecan plus durvalumab) works better than the current standard treatment for people with triple-negative or hormone receptor-low breast cancer that hasn't spread. About 1,900 adults with stage II or III breast c…

This study tests an experimental drug called CFI-400945 in people with advanced or metastatic breast cancer that has not responded to standard chemotherapy. The goal is to see if the drug can shrink tumors or slow the disease. About 51 participants will receive the drug, and rese…

This early-stage study tests the safety and effectiveness of combining two drugs, abemaciclib and pembrolizumab, in 100 people with advanced non-small cell lung cancer or hormone receptor-positive, HER2-negative breast cancer that has spread. The goal is to see if the combination…

This study tests a new oral drug, vepdegestrant, combined with abemaciclib in people with advanced or metastatic ER+ breast cancer that no longer responds to previous treatments. About 37 adults will take both pills at home daily until their cancer worsens or side effects become …

This early-phase study tests a new drug combination for people with metastatic breast cancer that has low or no HER2 protein. The goal is to find a safe dose of valemetostat when given with the standard drug trastuzumab deruxtecan. About 17 adults with HER2 low, ultra-low, or nul…

This early-stage trial tests the safety and effectiveness of combining the experimental drug Ipatasertib with standard hormone therapy, with or without another targeted drug, in 77 postmenopausal women with advanced hormone receptor-positive (HR+) breast cancer that has spread. T…

This early-phase study tests a new drug called BL-M02D1 in about 82 people with advanced triple negative breast cancer or other solid tumors that have spread and are not curable with current treatments. The main goals are to check the drug's safety, find the best dose, and see if…

This study looks at whether some women with HER2-positive early breast cancer can be treated with a combination of two targeted drugs (pertuzumab and trastuzumab) without needing chemotherapy. The researchers are selecting patients whose tumors are strongly driven by the HER2 pat…

This study tests whether taking hormone-blocking pills for 6 months before surgery helps remove all cancer cells in one piece for women with early-stage, estrogen-positive breast cancer. Eight postmenopausal women with low-risk tumors are participating. The goal is to see if this…

This study tested whether adding the drug everolimus to standard hormone therapy for one year could help prevent breast cancer from returning in people with high-risk, hormone receptor-positive, HER2-negative breast cancer. About 1,900 participants were randomly assigned to recei…

This study tests a drug called trastuzumab deruxtecan (T-DXd) in about 500 people with advanced HER2-positive breast cancer that has worsened after prior treatments. Some participants have brain metastases, others do not. The goal is to see how well the drug shrinks tumors and de…

This study tests a new drug, MK-7119 (tucatinib), combined with two standard drugs (trastuzumab and capecitabine) in 66 people with advanced HER2+ breast cancer that has stopped responding to prior treatments. The main goal is to see if the combination can shrink tumors. Particip…

This study tested whether giving a single dose of radiation along with the immunotherapy drug pembrolizumab before surgery is safe and effective for people with early-stage breast cancer. 27 participants received the combination, and researchers measured tumor shrinkage and immun…

This study tests two drugs, CFI-400945 and durvalumab, in women with advanced triple negative breast cancer that cannot be cured. The goal is to see if the combination can shrink tumors or control the disease. About 15 participants will receive the treatment and be monitored for …

This study tests a combination of two experimental drugs (LEE011 and BYL719) with a standard hormone therapy (letrozole) in about 255 women with advanced ER+ breast cancer. The goal is to find safe doses and see if the triple combination can better control the cancer. Participant…

This study tests whether adding AGuIX gadolinium-based nanoparticles to standard stereotactic radiation can better control brain metastases that are at high risk of coming back after radiation alone. About 134 adults with brain tumors from cancers like melanoma, lung, breast, or …

This study looks at whether getting extra check-ups and support from a team of health professionals (like nurses, dietitians, and exercise therapists) can help people with breast cancer manage side effects from chemotherapy. About 80 adults with breast cancer will either receive …

This early-phase study tests a new drug called LOXO-783 in people with advanced breast cancer or other solid tumors that have a specific change in the PIK3CA gene. The main goals are to find the safest dose and check for side effects. About 193 participants will take the drug alo…

This study looks at whether people with breast or prostate cancer that has spread to the bones can safely stop or reduce their bone-strengthening medication after taking it for at least two years. The goal is to see if this approach maintains quality of life and prevents bone com…

This study looks at whether women with triple-negative or HER2-positive breast cancer can safely avoid sentinel lymph node biopsy if their tumor disappears completely after chemotherapy. About 350 women from Europe will join, and doctors will check if cancer returns in the armpit…

This study looks at whether giving partial breast radiation and chemotherapy at the same time is as safe and works as well as giving them at different times. About 81 women with early-stage breast cancer who had surgery will be randomly assigned to one of the two schedules. The m…

This study tested whether adding the drug abemaciclib to standard hormone therapy helps slow the growth of advanced breast cancer in postmenopausal women. The trial included 463 women with hormone receptor-positive, HER2-negative breast cancer that had spread or returned. The goa…

This study tests a new drug called CFI-402257 combined with the standard chemotherapy paclitaxel for women with advanced HER2-negative breast cancer that cannot be cured. The goal is to see if the combination works better than paclitaxel alone at shrinking tumors or slowing the d…

This study tests a combination of three drugs (cisplatin, romidepsin, and nivolumab) in people with advanced triple-negative breast cancer or breast cancer linked to BRCA gene mutations. The goal is to see if the combination can shrink tumors and control the disease. About 51 adu…

This study looks at how well and how safely the biosimilar drug Zedora works in women with early-stage HER2+ breast cancer after surgery. About 170 women from several Brazilian hospitals will be followed to track cancer return, survival, and side effects. The goal is to gather re…

This study looks at whether women aged 65 and older with early-stage, estrogen-positive breast cancer can safely skip sentinel node biopsy (a procedure to check lymph nodes) when having a lumpectomy. The goal is to see if skipping this step leads to cancer coming back in the lymp…

This study tests whether a shorter course of radiation (1 to 5 days) after breast cancer surgery is as safe and effective as the standard 6.5-week treatment. It involves 121 women aged 40 and older with small tumors. The goal is to reduce side effects and improve convenience whil…

This study looks at 100 women with early-stage HR+/HER2- breast cancer to see if adding CDK4/6 inhibitors to standard hormone therapy before surgery improves outcomes. Researchers use a genetic risk score and early changes in a cell growth marker (Ki-67) to decide who gets the ex…

This study tests a new drug (PF-07220060) combined with letrozole against standard treatments for people with HR-positive, HER2-negative advanced or metastatic breast cancer who have not had prior treatment for advanced disease. About 1,035 adults will be randomly assigned to rec…

This study tested a combination of two drugs, pembrolizumab and fulvestrant, in 47 people with advanced or metastatic hormone receptor-positive, HER2-negative breast cancer. The goal was to see if the combination could shrink tumors or keep them stable for at least four months. T…

This study tests a combination of two targeted drugs (trastuzumab and pertuzumab) plus hormone therapy given after surgery for people with stage I hormone receptor-positive, HER2-positive breast cancer. The goal is to see if this approach helps prevent the cancer from coming back…

This trial tests a two-step treatment for people with advanced breast cancer that cannot be cured by surgery or radiation. First, patients receive a drug called talazoparib alone, then they get talazoparib combined with avelumab. The main goal is to check safety and side effects,…

This study tests whether doctors can safely reduce the amount of chemotherapy given before surgery for HER2-positive breast cancer. By using medical imaging to monitor how the tumor responds, the goal is to give only as much chemo as needed. The study involves 462 participants wi…

This study tests whether adding the immunotherapy drug toripalimab to standard chemotherapy before surgery can help eliminate tumors in people with localized triple-negative breast cancer. About 51 women with early-stage, untreated disease will receive the combination, then have …

This early-stage study tests a combination of two drugs—trastuzumab deruxtecan and pembrolizumab—in people with advanced breast or non-small cell lung cancer that has spread. The goal is to find the best dose and see how well the combo shrinks tumors. About 115 adults with HER2-p…

This study tests if a shorter course of radiation (3 sessions over 5 days) is as safe and effective as the standard 5-session course for women with early-stage breast cancer. The trial involves 284 post-menopausal women who have had surgery to remove their tumor. The main goal is…

This study tests if a robot-assisted surgical system (da Vinci SP) is as safe and effective as traditional open surgery for nipple-sparing mastectomy in women with early-stage breast cancer. About 204 participants will be randomly assigned to one of the two procedures. The goal i…

This study offers continued access to the drug olaparib for people with ovarian or breast cancer who were already benefiting from it in a previous clinical trial. About 185 participants will keep receiving treatment as long as their doctor believes it helps them. The main goal is…

This study tests two experimental treatments (Dato-DXd alone or with durvalumab) against standard therapy for people with triple-negative breast cancer who still have cancer cells in the breast or lymph nodes after surgery and chemotherapy. About 1,174 participants will be random…

This study tests the safety of combining an experimental drug (neratinib) with a standard chemotherapy (capecitabine) using a different dosing schedule for people with advanced HER2-positive breast cancer. About 34 adults with stage IV disease will receive different dose levels t…

This early-stage trial tests the safety and best dose of combining two drugs, alpelisib and sacituzumab govitecan, for people with advanced HER2-negative breast cancer that has spread or come back. The study includes 18 adults with this type of cancer. The main goal is to find th…

This early-phase study tests an experimental cell therapy called P-MUC1C-ALLO1 in 180 adults with advanced solid tumors (e.g., breast, ovarian, lung, pancreatic cancers) that have not responded to standard treatments. The therapy uses donor immune cells engineered to target a pro…

This study tests a new drug called TQB3616 combined with standard hormone therapy to see if it can stop breast cancer from returning in people with HR-positive, HER2-negative breast cancer. About 1,946 women who have had surgery will receive either the new drug or a placebo, plus…

This study tests two targeted drugs, T-DM1 and pertuzumab, given before surgery to people with early-stage HER2-positive breast cancer. The goal is to see if this combination can completely eliminate cancer cells in the breast, potentially reducing the need for more aggressive tr…

This phase 2 trial tests a new oral drug (TQB3616) combined with hormone therapy for people with a common type of breast cancer (HR-positive, HER2-negative) that has stopped responding to standard CDK4/6 inhibitor pills. The study enrolls 33 adults whose cancer has returned or sp…

This study tests whether a new drug combination (inavolisib plus fulvestrant) works better than an existing one (alpelisib plus fulvestrant) for people with a specific type of advanced breast cancer (HR-positive, HER2-negative, with a PIK3CA mutation) that has worsened after prio…

This study tests whether adding extra immunotherapy before standard treatment can help the immune system better attack triple negative breast cancer. About 12 adults with untreated, locally confirmed TNBC will receive different immunotherapy combinations plus chemotherapy before …

This study tests a modified radiation therapy for women aged 50 and older with early-stage, low-risk breast cancer. Instead of the standard every-other-day schedule over 10 days, patients receive a slightly lower dose of radiation once daily for 5 days in a row. The goal is to se…

This study tests an experimental drug called GDC-9545, alone or with other medicines, in people with advanced estrogen receptor-positive breast cancer that has spread. The main goals are to check the drug's safety and find the best dose. About 181 participants will take part in t…

This study tests a combination of two drugs, lenvatinib and letrozole, given before surgery to postmenopausal women with a common type of breast cancer (hormone receptor positive). The goal is to see if the drugs can shrink the tumor enough to improve surgical outcomes. About 40 …

This study tests whether combining two immunotherapy drugs, nivolumab and ipilimumab, can shrink tumors in people with a rare, advanced form of HER2-negative breast cancer that has many genetic mutations. The trial enrolled 30 participants and is no longer recruiting new patients…

This early-phase trial tests a new drug called SRG-514, which is applied directly to the tumor site during breast-conserving surgery. The goal is to find the safest dose and see how the body handles it. About 24 adults with breast cancer are taking part. This study focuses on saf…

This study tests whether a precise, high-dose radiation treatment called stereotactic body radiation therapy (SBRT) can help control breast cancer that has spread to a few spots in the body. About 154 women with metastatic breast cancer who are starting their first treatment will…

This study tests whether adding the immunotherapy drug pembrolizumab to standard chemotherapy can eliminate all signs of cancer in people with early-stage triple-negative breast cancer before they have surgery. About 31 participants with small tumors (1 to 2.5 cm) that haven't sp…

This study tests whether adding afuresertib to fulvestrant can help people with a certain type of advanced breast cancer (HR+/HER2-) that has stopped responding to standard therapies. About 256 adults whose tumors have specific genetic changes (PIK3CA/AKT1/PTEN) will receive eith…

This early-phase study tests a new drug called A166 in 120 adults with advanced HER2-expressing solid tumors (like breast cancer) that cannot be removed by surgery or have spread. The main goal is to check safety and find the right dose, while also seeing if the drug shrinks tumo…

This study tests a new drug called SKB264 in people with advanced solid tumors (like lung, breast, or ovarian cancer) that have not improved with standard treatments. The goal is to find the best dose and see if it can shrink tumors. About 1,410 participants will receive the drug…

This early-phase trial tests a treatment for adults with metastatic solid tumors (like colorectal, lung, or breast cancer) that have a specific genetic change called KRAS. Doctors take a person's own white blood cells, modify them in a lab to better recognize and attack cancer ce…

This study tests whether freezing the tumor (cryoablation) combined with an immunotherapy drug before surgery can help prevent breast cancer from coming back in women with triple-negative breast cancer. About 51 women who still have cancer after initial chemotherapy will receive …

This study tests whether a daily pill called olaparib can help prevent breast cancer from returning in people with inherited BRCA1 or BRCA2 gene mutations who have already completed surgery and chemotherapy. About 1,800 participants with high-risk, HER2-negative breast cancer rec…

This study tests a new drug called tobemstomig combined with chemotherapy (nab-paclitaxel) against the current standard treatment (pembrolizumab plus chemotherapy) for people with a type of advanced breast cancer called PD-L1-positive triple-negative breast cancer. About 83 parti…

This study is testing an experimental drug called AZD5305, a PARP inhibitor, in people with advanced solid tumors like ovarian, breast, pancreatic, and prostate cancer. The goal is to see if the drug is safe and tolerable when given alone or with other cancer treatments. About 70…

This study tests whether a newer drug, trastuzumab deruxtecan (T-DXd), given alone or with other drugs before surgery, works better than the standard treatment for people with high-risk HER2-positive early breast cancer. About 927 adults will take part. The main goal is to see if…

This study looks at whether skipping axillary surgery (removing lymph nodes under the arm) is as safe as doing a sentinel lymph node biopsy in women with early-stage breast cancer who have breast-conserving surgery. The goal is to see if avoiding this surgery leads to fewer side …

This study tests whether adding the drug pyrotinib to standard chemotherapy before surgery can improve outcomes for women with stage II or III hormone receptor-positive, HER2-negative breast cancer that also has high levels of the HER4 protein. About 140 participants will receive…

This study looks at 1,000 postmenopausal women with early breast cancer to find out whether giving chemotherapy and hormone therapy at the same time or one after the other works better. The goal is to see which approach helps keep cancer from coming back over 15 years. Participan…

This study looks at whether women with triple-negative or HER2-positive breast cancer who have a complete response to chemotherapy can safely skip sentinel lymph node biopsy (SLNB). SLNB can cause side effects like arm swelling and pain. The trial will track if skipping it leads …

This study tests a combination of two drugs, capivasertib and fulvestrant, in Chinese patients with advanced or metastatic HR+/HER2- breast cancer that has returned or worsened after hormone therapy. About 258 participants will receive the treatment to see if it delays the need f…

This study tests a new oral drug, ARV-471, combined with ribociclib in people with advanced or metastatic ER+ breast cancer that no longer responds to prior treatments. About 20 adults will take both pills daily at home. Researchers will check safety and whether tumors shrink. Th…

This study offers continued treatment with the cancer drug palbociclib to people who have already benefited from it in earlier Pfizer studies. It includes 35 adults with breast or head/neck cancer. The main goal is to monitor safety and track any serious side effects over time.

This study looks at different combinations and schedules of chemotherapy drugs for women with breast cancer that has spread to lymph nodes. The goal is to see if adding a drug called fluorouracil or giving treatment every 2 weeks (with a support drug to help the immune system rec…

This early-phase study tests a new drug, OP-1250, combined with the approved drug palbociclib in 60 adults with advanced or metastatic HR-positive, HER2-negative breast cancer. The goal is to find the safest dose and check for side effects, while also seeing if the combination ca…

This study tests whether combining two drugs (niraparib and dostarlimab) with radiation therapy is safe and effective for people with metastatic triple-negative breast cancer that has not responded to immunotherapy or is PD-L1 negative. About 32 adults with this aggressive cancer…

This study tests whether giving two drugs, olaparib and pembrolizumab, before standard surgery can shrink breast tumors in people with triple-negative or hormone receptor-positive, HER2-negative breast cancer who have specific gene mutations. The goal is to see if the combination…

This study looks at whether women with HER2-positive breast cancer who have a complete response to pre-surgery chemotherapy and antibody drugs can safely avoid more chemotherapy after surgery. Instead, they would receive only two antibody drugs (trastuzumab and pertuzumab) after …

This study tests a new drug (MEN1611) combined with chemotherapy (eribulin) in people with advanced breast cancer that has specific genetic changes (PIK3CA/PTEN). The goal is to see if the combination can shrink tumors or stop them from growing. The trial includes 14 adults whose…

This study tests a precise type of radiation called proton therapy given after surgery for stage II/III breast cancer. The goal is to see if it can effectively treat cancer while reducing damage to the heart and other organs. About 220 women will receive this treatment and be fol…

This study tested whether adding the drug abemaciclib to standard hormone therapy (anastrozole or letrozole) helps postmenopausal women with a certain type of advanced breast cancer (HR+, HER2-). About 493 women took part, receiving either abemaciclib or a placebo alongside their…

This early study tests whether adding hyperbaric oxygen therapy (breathing pure oxygen in a pressurized chamber) to standard cancer treatment can slow or shrink breast cancer that has spread to the lungs. Ten women aged 18-75 whose cancer progressed after at least one prior treat…

This study tests a high-dose, precise radiation treatment called SBRT for 15 breast cancer patients who cannot undergo surgery. The goal is to see if it safely controls the tumor and improves survival. Participants receive 5 radiation sessions and are followed for 5 years.

This study looks at whether using radiofrequency ablation (a heat treatment) on the area where a breast tumor was removed can lower the chance that cancer comes back or that more surgery is needed. About 104 women aged 50 and older with early-stage breast cancer will get this ext…

This study tests a high-precision radiation treatment called SBRT for people with advanced breast cancer who cannot have surgery. Twenty-four participants will receive 4 radiation sessions over 12-15 days. The goal is to see if this treatment is safe and helps control the disease…

This phase 3 trial tests whether adding a new drug called ipatasertib to standard therapy (fulvestrant) can slow the growth of advanced ER-positive, HER2-negative breast cancer. The study involves 250 women whose cancer progressed after initial treatment with CDK 4/6 inhibitors a…

This study tests an experimental drug, zelenectide pevedotin, in people with advanced breast cancer that has a specific genetic change called NECTIN4 amplification. The trial includes two groups: one with hormone receptor-positive/HER2-negative cancer and another with triple-nega…

This phase 3 study tests a 3-month injection (TOL2506) to temporarily stop ovarian function in premenopausal women with HR+, HER2- breast cancer. The goal is to lower hormones that can fuel cancer growth. About 250 participants will receive the injection along with standard hormo…

This study tests whether adding the drug capecitabine to standard chemotherapy before surgery can completely eliminate early triple-negative breast cancer. About 325 adults with node-positive or larger tumors are participating. The main goal is to see if the combination leads to …

This study tests whether adding ribociclib to the hormone therapy letrozole for 24 weeks before surgery can improve outcomes for postmenopausal women with ER-positive, HER2-negative early breast cancer. The goal is to help more women achieve a low-risk score (PEPI 0) at surgery, …

This early-phase study tests a new treatment called HER2-CAR T cells for people with HER2-positive cancers that have spread to the brain or its lining. The treatment involves taking the patient's own immune cells, modifying them to recognize and attack HER2-positive cancer cells,…

This study compares a single dose of radiation to five doses after breast cancer surgery for people with very early-stage breast cancer. The goal is to see if one dose works just as well at preventing the cancer from coming back, while also reducing side effects and improving qua…

This study tests a treatment using a patient's own immune cells (T cells) that are modified in a lab to attack cancer cells with a protein called mesothelin. It is for people with malignant pleural disease, including mesothelioma and cancers that have spread to the chest lining. …

This study tests a new way to rebuild a breast after cancer surgery. Doctors use a tiny cut under the arm to remove breast tissue and then add the patient's own fat in stages to shape a new breast. The goal is to see if this method leads to better satisfaction and quality of life…

This study tested a special PET scan that uses a radioactive tracer (64Cu-DOTA-trastuzumab) to find HER2-positive breast cancer tumors in women with advanced stage IV disease. The goal was to see if the scan could tell the difference between HER2-positive and HER2-negative tumors…

This study compares how well ultrasound and MRI find breast cancer in women with dense breasts who have already had breast cancer. About 1,756 women will get either an ultrasound or an MRI (short or full version) to see which test catches more cancers. The goal is to find the bes…

This study checks whether a breast MRI-guided biopsy can correctly tell if a woman's breast cancer has completely disappeared after chemotherapy. About 31 women whose tumors no longer show on MRI will get a biopsy to see if it matches the final surgical result. If the biopsy is a…

This study was designed to see if analyzing tiny particles called exosomes in spinal fluid could help doctors diagnose breast cancer that has spread to the lining of the brain. It planned to enroll breast cancer patients with suspected spread and compare the exosome protein patte…

This study is testing a short (under 5 minutes) MRI technique called DWI that does not require a contrast dye. The goal is to see if it can find breast cancers in women with dense breasts that mammograms might miss. About 269 women with dense breasts will participate. If successf…

This pilot study tests a special PET scan that uses a radioactive tracer (64Cu-M5A) to find cancers that produce a protein called CEA. The goal is to see if this scan can detect tumors that standard methods might miss. About 20 adults with breast, colon, lung, or other CEA-positi…

This study looks at whether a special MRI scan that does not use contrast dye can accurately find breast disease. About 1,030 women at risk or with symptoms will be scanned. The goal is to see if this safer, more comfortable method works as well as standard care.

This study looks at whether contrast-enhanced mammography (CEM) can find breast cancer more accurately than standard mammography in women who have already had breast cancer. About 1,647 women aged 30-85 will get both types of mammograms to compare detection rates and false alarms…

This study tests a new method using a fluorescent dye called indocyanine green (ICG) to find sentinel lymph nodes in breast cancer patients. The current method uses a radioactive tracer that has limited availability and exposes patients to radiation. About 493 women with early-st…

This study tests if a simple blood test can tell which women are very unlikely to have breast cancer after a suspicious mammogram. About 75% of women called back for extra tests turn out to be fine, causing stress and wasted resources. The goal is to use blood biomarkers to safel…

This study tests advanced ultrasound techniques to make breast images clearer, helping doctors spot microcalcifications, cysts, and tumors more accurately. About 252 women with certain breast findings will undergo standard and experimental ultrasound imaging. The goal is to impro…

This study tests a new device called the LymphaTech scanner to see if it can accurately measure arm swelling (lymphedema) in 100 women treated for breast cancer. The scanner is compared to a standard tool called the Perometer. The goal is to find a quicker, easier way to screen f…

This study tests a new, faster breast MRI technique called GRASP. The goal is to see if it can accurately tell the difference between harmless and cancerous breast lumps. About 264 women who are already scheduled for a standard breast MRI will take part. If successful, this could…

This study tests a new dye called LS301-IT that makes cancer cells glow during breast cancer surgery. About 100 women with early-stage breast cancer or DCIS will receive the dye before their partial mastectomy. The goal is to see if the dye is safe and helps surgeons remove all c…

This study compares a new cone beam breast CT scan to standard mammography for breast cancer screening. About 1,000 women from routine screening or diagnostic groups will receive both scans within 4 weeks. Researchers will measure radiation dose and how often each method requires…

This study tests a low-cost, portable ultrasound device (POCUS) combined with artificial intelligence to detect breast cancer. It aims to see if this approach works as well as standard methods, especially in places where expensive equipment and experts are scarce. About 600 women…

This study is testing a special smart bra that can detect breast abnormalities, potentially helping with breast cancer screening. About 70 women—some healthy and some already diagnosed with invasive breast cancer—will wear the device to see how well it finds tumors. The goal is t…

This study was designed to test a new radioactive tracer called [18F]GEH121224 for PET scans in people with advanced HER2-positive breast cancer. The goal was to see if it could safely and accurately detect cancer spread. The study was withdrawn before any participants were enrol…

This study looks at whether combining mammograms and breast MRIs can find breast cancer earlier in women at high risk, such as those with BRCA gene mutations. About 305 participants will get both scans yearly, and researchers will track how well they detect cancer and how the scr…

This study looks at whether a combination of two hormones (bazedoxifene and conjugated estrogens) can reduce breast cancer risk in women going through menopause who also have hot flashes. About 120 women at higher risk for breast cancer will either receive the treatment for 6 mon…

This study tests whether a low dose of tamoxifen, a hormone-blocking drug, can reduce the risk of breast cancer in people who have had radiation therapy for other cancers. About 84 participants took either low-dose tamoxifen or a placebo for a period of time. The main goal was to…

This study tests whether the DigniCap scalp cooling system can prevent chemotherapy-induced hair loss in Black patients with early-stage breast cancer. About 30 participants will use the cooling cap during at least four cycles of taxane or anthracycline-based chemo. The goal is t…

This study tests a surgical technique called ARM (Axillary Reverse Mapping) to prevent lymphedema—painful arm swelling—after lymph node removal in breast cancer patients. About 100 women will be randomly assigned to receive either standard surgery or surgery with the ARM techniqu…

This study looks at whether taking omega-3 fatty acids (like fish oil) can lower the chance of breast cancer returning in women who have already been treated for a certain type of breast cancer. 80 women will take either a low or high dose of omega-3s for 12 months. Researchers w…

This study looks at whether adding a polygenic risk score (a measure of many small genetic factors) to standard risk tools helps women ages 35-75 at high risk for breast cancer decide on prevention steps, such as taking medication, having risk-reducing surgery, or getting extra i…

This study is testing a mobile app designed to help people who have had breast cancer or rare cancers cope with the fear that their cancer might return. Researchers will work with 252 survivors to develop and refine three different versions of the app. The goal is to see if the a…

This study looks at whether a simple writing exercise can improve quality of life for people recently diagnosed with breast cancer. Participants will write about their thoughts and feelings for 20 minutes, once a week for four weeks. The study will track changes in well-being thr…

This study tests whether listening to nature sounds (like birds or water) during a breast core biopsy can lower pain and anxiety compared to standard supportive conversation. About 200 adults having a breast biopsy will be randomly assigned to either nature sounds or usual care. …

This study aims to create and test a shortened mindfulness program to help older African American women who have had breast cancer feel less depressed. About 23 women aged 65 and older with mild to moderate depression will take part. The program is designed with community input t…

This study looks at whether supervised exercise (a mix of aerobic and resistance training) before surgery can help shrink breast cancer tumors in women undergoing chemotherapy. About 100 women with newly diagnosed breast cancer will take part. The main goal is to see if exercise …

This study looks at two treatments for vaginal dryness in women with estrogen-receptor-positive breast cancer who are taking aromatase inhibitors. About 33 participants will use either a vaginal estrogen ring or a Replens moisturizer for six months. The goal is to see which optio…

This study looks at whether taking synbiotics (probiotics plus fiber) or prebiotics (fiber) daily for 4 months can reduce memory and thinking problems (chemobrain) in breast cancer patients receiving chemotherapy. About 80 adults with stage IB to IIIC breast cancer will take eith…

This study tests a mindfulness-based program (Nite2Day) for women with breast cancer who have trouble sleeping. Participants learn strategies to cope with nighttime sleep issues and daytime symptoms like fatigue, stress, and pain through six remote sessions with a therapist. The …

This study tests whether starting abemaciclib at a lower dose and gradually increasing it causes fewer side effects than the standard fixed dose. About 90 adults with early-stage, hormone receptor-positive breast cancer will take part. The goal is to see if this approach helps pe…

This study looks at whether a faster course of radiation therapy (called accelerated radiation) is safe for women with breast cancer who have already had chemotherapy and surgery. About 88 women with stage I to III breast cancer will receive this shorter radiation to the breast a…

This study tests a portable cooling cap worn during chemotherapy to prevent hair loss in women with early-stage breast cancer. The cap cools the scalp to reduce damage to hair follicles from chemo drugs. The study involves 40 women and measures how well the cap works and any side…

This study tests different local treatments for vaginal atrophy (dryness, pain, irritation) in 160 breast cancer patients who are on hormone therapy. The goal is to see which treatment works best to improve symptoms and quality of life over 12 weeks, while also checking hormone l…

This study tests a fixed-dose combination of two drugs, netupitant and palonosetron (NEPA), to prevent nausea and vomiting caused by chemotherapy in breast cancer patients. About 55 women in Hong Kong receiving a specific chemo regimen (adriamycin and cyclophosphamide) will take …

This study compares two relaxation programs involving stretching and relaxation techniques to see if they improve physical and emotional well-being in women with breast cancer receiving radiation therapy. About 700 women with early-stage breast cancer will participate, with some …

This study looks at whether flibanserin, a drug for low sexual desire, can be safely taken by breast cancer survivors who are on tamoxifen or similar hormone therapies. About 43 women with a history of breast cancer and no current disease will take flibanserin for 24 weeks. The m…

This study tests whether injecting platelet-rich plasma (PRP) into the vulva and vagina can ease menopause-like symptoms in breast cancer survivors. About 18 women who have had breast cancer and have low vaginal health scores will receive PRP injections. The goal is to see if sym…

This study looks at whether listening to music (receptive music therapy) can help women with breast cancer feel less anxious and depressed, and improve their quality of life during surgery and chemotherapy. About 90 women will be randomly assigned to either a music therapy group …

This study tests whether eating a low-calorie diet before chemotherapy can reduce side effects like fatigue, nausea, and mouth sores, and also improve how well the treatment works. About 130 adults with breast or prostate cancer will be randomly assigned to either follow the spec…

This study looks at whether adding fasting (intermittent or water-only) to standard chemotherapy can help women with breast cancer. Researchers will check tumor markers, immune cells, and quality of life in 60 patients. The goal is to see if fasting makes chemo more effective and…

This study tests a special cooling cap (Orbis Paxman system) to prevent hair loss in Chinese women with breast cancer undergoing chemotherapy. 25 participants will use the cap during chemo sessions. The goal is to see if it safely reduces hair loss and improves quality of life.

This study looks at whether curcumin, the ingredient in turmeric, can reduce joint pain in breast cancer survivors caused by aromatase inhibitor drugs. About 42 postmenopausal women will take either curcumin or placebo capsules for 3 months. The goal is to see if curcumin improve…

This study tests an exercise program designed for Hispanic women who have had breast cancer. The goal is to find the best ways to help them become more active and improve their health. Researchers will measure changes in exercise habits and look at certain blood markers. The stud…

This study looks at whether a mobile app can help breast cancer survivors exercise more after finishing treatment. About 200 people who had early-stage breast cancer will either use the app for 12 weeks or get standard exercise guidelines. The goal is to see if the app increases …

This study looks at whether adding mindfulness and social support to a phone-based exercise program helps breast cancer survivors become more active and stay active. About 304 women who finished cancer treatment within the past 5 years will take part. The goal is to see if these …

This study tests a memory training program for breast cancer survivors who have memory problems after chemotherapy. About 60 women who finished chemo 1-10 years ago will use either a challenging or easier version of the software to see if it improves memory and attention. The goa…

This study looks at whether a smartphone app that sends text reminders can help people with breast cancer remember to take their medication, palbociclib, on schedule. About 45 participants will use the app, and researchers will track how accurately they take their pills. The goal…

This study looks at whether a 12-week program of online chair-based exercise and health education, along with a full geriatric assessment, can help older adults (65+) with cancer and their support person. The goal is to see if this approach is practical and helps improve physical…

This study follows 500 women with breast cancer who receive targeted radiotherapy after lumpectomy or mastectomy. The goal is to track side effects and quality of life during and after treatment. Researchers aim to understand how well patients tolerate this type of radiation and …

This study looks at whether a device called Amma can help women with early-stage breast cancer keep more of their hair during chemotherapy. About 15 women will use the device and report how satisfied they are. The goal is to see if offering this option in cancer centers is practi…

This study explores whether music therapy can reduce anxiety, fatigue, and other symptoms in women with breast cancer undergoing chemotherapy. Twenty-four participants will take turns having music therapy sessions and going without, so each person acts as their own comparison. Th…

This study is for women aged 18-39 who were recently diagnosed with breast cancer (stages 0-3). It tests a web-based portal that provides symptom tracking, supportive care information, and peer support. The goal is to see if using the portal reduces common symptoms like vaginal d…

This study looks at two ways to rebuild a breast after mastectomy: using a small piece of back muscle (minimal flap) or an implant. The goal is to see which method gives better shoulder movement, less pain, and a more satisfying appearance. About 190 women who had or will have br…

This study compares two different radiation schedules for people with breast cancer who have had surgery. The goal is to see which schedule causes less fatigue and improves quality of life. About 132 adults will receive either standard or shorter radiation sessions to the breast,…

This study tests a 3-month intermittent fasting program for adults who have had breast cancer and are overweight or obese. Participants follow a 4:3 fasting schedule (3 modified fast days per week) and aim for 150 minutes of physical activity weekly. The goal is to see if the pro…

This study looks at whether virtual reality exercises or standard physical therapy, with or without lifestyle changes, can help women who had breast cancer surgery move their arms better and feel less pain. About 60 women aged 30-60 will take part. The goal is to find which appro…

This study tests if whole-body cryotherapy (extreme cold) can reduce joint pain caused by aromatase inhibitors, a common hormone therapy for breast cancer. About 70 women with breast cancer who have joint pain from their medication will receive either real or placebo cryotherapy …

This study looks at whether a 16-week home exercise program can help Black and Hispanic patients with breast, colorectal, or prostate cancer become more active while on chemotherapy. Participants are split into three groups: supervised exercise via Zoom, unsupervised exercise, or…

This study tests whether an artificial intelligence-based management model can reduce anxiety and depression in 300 women with HR+/HER2- breast cancer who are taking CDK4/6 inhibitor pills at home. Participants will be randomly assigned to one of three follow-up approaches: AI-gu…

This study looks at whether giving a single dose of radiation directly to the tumor site during breast-conserving surgery can reduce fatigue compared to the usual 3-6 weeks of whole breast radiation. It involves women aged 50 and older with low-risk, early-stage breast cancer. Th…

This study tests whether a single, high dose of radiation given before surgery can safely treat early-stage breast cancer while keeping the breast looking good. About 110 women with small, early breast cancers will receive one 21 Gray dose of radiation, then have surgery. The mai…

This study tests whether talking to an exercise specialist over the phone can help breast and colorectal cancer survivors become more physically active after finishing chemotherapy. About 120 adults who completed treatment for early-stage cancer will be randomly assigned to recei…

This study looks at whether a 12-week dance program can improve physical and emotional well-being in women undergoing breast cancer treatment. Twenty-eight women will either take dance classes twice a week or continue their usual routine. Researchers will measure pain, fatigue, q…

This study tests whether starting hormone therapy every other day for a month before switching to daily dosing helps patients tolerate it better and stay on track. About 240 adults with early-stage hormone-sensitive breast cancer will be randomly assigned to either standard daily…

This study tests an online self-help program called Together After Cancer for breast cancer survivors and their intimate partners. The program includes brief coach calls and aims to improve the survivor's quality of life and the couple's relationship satisfaction. About 480 coupl…

This study looks at whether women with early breast cancer (tumors smaller than 5 cm) and no signs of cancer in the lymph nodes can safely avoid axillary surgery. About 800 women will be randomly assigned to either have a sentinel lymph node biopsy or no surgery at all. The goal …

This study tests whether using a fitness tracker and health coaching can help young Hispanic women who have ongoing pain after breast cancer surgery become more active and feel better. About 25 women who had surgery at least 6 months ago and have moderate to severe pain will take…

This study looks at whether a 30-minute education session with a radiation therapist can help breast cancer patients feel less anxious and more in control during their radiation treatment. About 109 patients will be randomly assigned to either receive this extra session or standa…

This study looks at whether special numbing techniques used during breast cancer surgery can help prevent chronic pain that often lasts for months or years after the operation. About 1,500 women having breast cancer surgery will be followed for a year to see if these techniques r…

This study aimed to see if offering beauty treatments (like skincare or makeup) to women right after breast cancer surgery could improve how they feel about their bodies and their overall quality of life. It planned to compare women who received these treatments with those who di…

This study tests whether live exercise coaching plus a personalized digital app can improve quality of life for cancer survivors. About 146 adults with breast, lung, prostate, colorectal, or other cancers who had treatment in the last year will use the program for 18 months. Rese…

This study looks at whether using an interactive 3D tool during a surgical consultation helps women with breast cancer feel more satisfied with the information they receive about breast reconstruction options. About 88 women planning mastectomy will take part. Researchers will me…

This study tests whether acupuncture can improve memory, concentration, and sleep problems in 270 breast cancer survivors. Participants receive either real acupuncture, placebo acupuncture, or no acupuncture, and complete questionnaires over 26 weeks. The goal is to see if acupun…

This study tests a shorter course of radiation to the lymph nodes in breast cancer patients. The goal is to see if it reduces long-term arm swelling while still preventing cancer from coming back. About 56 women will be followed for 3 years after treatment.

This study looks at whether a program combining exercise and psychological support can reduce anxiety and depression in breast cancer patients. About 200 women who have finished initial treatment for breast cancer and still feel anxious or depressed will take part. The goal is to…

This study follows over 64,000 adults who grew up on farms to see if early-life exposures to pesticides and other agricultural factors are linked to cancer. Participants fill out an online questionnaire and may provide biological samples. Researchers will track cancer and other d…

This study tests a new imaging method called DBT-TOBI, which combines a 3D mammogram with a light-based scan, to see if it can predict how well breast cancer responds to chemotherapy before surgery. About 30 women with HER2+ or triple-negative breast cancer will get scans before …

This study explores whether a special type of radiation therapy can protect the ovaries of young women (ages 18-50) undergoing pelvic radiation for cancers like uterine, rectal, or cervical cancer. The goal is to see if doctors can consistently see the ovaries on daily scans and …

This study was designed to watch for changes in tumor DNA in the blood of people with early breast cancer. It would have followed patients during and after treatment to see if the DNA test could spot remaining cancer. However, the study was withdrawn before any participants were …

This study looks at how immune checkpoint inhibitors, a type of immunotherapy for cancer, affect the tiny blood vessels in the heart. Researchers will use heart scans and blood tests in 25 adults with breast or lung cancer before and during treatment. The goal is to understand if…

This study looks back at over 1,000 women who had breast-conserving surgery for early breast cancer that couldn't be felt. It compares four methods (wire, radioactive seed, magnetic seed, and carbon dye) used to locate the tumor during surgery. The goal is to see which technique …

This study uses a special PET/CT scan with a tracer called 18F-FTT to measure PARP-1 activity in breast cancer tumors. About 50 adults with known or suspected breast cancer will get one or two scans. The goal is to see if the tracer can show how active the cancer is, not to treat…

This study tests whether a team-based rehab program can help breast cancer patients return to work. Sixteen working-age women with breast cancer and work difficulties will receive counseling, physical therapy, and job support. The goal is to see if the program is practical and he…

This study aimed to understand how psychological and social factors might affect the risk of chronic pain after breast cancer surgery. It planned to follow women undergoing mastectomy or lumpectomy and measure pain levels over time. However, the study was withdrawn before startin…

This study looks at whether women with early-stage breast cancer (tumors under 5 cm) and no signs of cancer in lymph nodes on ultrasound can safely avoid sentinel lymph node biopsy during breast-conserving surgery. About 1,734 women are randomly assigned to either skip the biopsy…

This study looks at how radiation therapy changes tumor DNA and immune cells in the blood of 217 breast cancer patients. The goal is to learn how these markers respond to treatment, which could help doctors customize radiation plans in the future. Participants are adults with bre…

This study tests better ways to help women in Kenya get screened for breast and cervical cancer and complete needed follow-up care. About 5,400 women aged 30-55 will take part. The goal is to find which strategies work best to catch cancer early and save lives.

This study tests a new imaging tool called MSOT that uses light and sound to create pictures of tumors. About 12 people with breast cancer or melanoma will get an MSOT scan before their usual biopsy. The goal is to see if MSOT can find tumors as well as standard methods like ultr…

This early-stage study planned to test whether injecting the seasonal flu vaccine directly into breast cancer tumors could help the immune system fight the cancer. It was designed for women with triple-negative or HER2+ breast cancer who were already scheduled for chemotherapy. T…

This study looks at how genetic testing for breast cancer affects patients' stress and anxiety levels. Researchers will track stress before and after testing in 164 women who either have breast cancer or are at high risk. The goal is to help doctors provide better emotional suppo…

This study looks at whether a special payment model helps doctors coordinate care better for cancer patients in Hawaii. It involves 7 participants with breast, colon, or lung cancer who are getting chemotherapy. The goal is to see if this approach improves health outcomes and low…

This study looks at whether a short exercise or mind-body program (like relaxation techniques) can help women with breast cancer feel less stressed and anxious while waiting for surgery. About 49 women will take part for 3-6 weeks before their operation. Researchers will also che…

This study is looking for ways to predict heart problems that can happen during breast cancer treatment. Researchers will use blood tests and special heart ultrasounds to find early warning signs. The study involves 700 adults with breast cancer who are receiving certain types of…

This study looks at how people feel physically and emotionally after a breast biopsy for certain non-cancerous breast conditions (like atypical hyperplasia or DCIS). Over 900 participants from several hospitals answered questions about pain and quality of life, on average nearly …

This study is looking at 268 women with early breast cancer to see if certain immune-related factors in the tumor and blood can predict whether chemotherapy before surgery will be successful. Researchers will analyze tumor tissue and blood samples taken before treatment and check…

This study aims to understand how normal breast tissue looks on MRI and mammogram, and how that might affect a woman's risk of developing breast cancer. Researchers will compare images and information from questionnaires and medical records from over 2,000 women. The goal is to f…

This study looks at how common BRCA1/2 gene mutations are in people with high-risk early breast cancer that is HER2-negative. It also tracks what treatments they receive and how they do over time. About 625 adults in Russia who have already had surgery will take part, and no new …

This study looks at four different tools to help people who have had cancer improve their diet and physical activity. About 353 cancer survivors will try these tools to see which ones work best. The goal is to find simple ways to help survivors follow healthy lifestyle guidelines…

This study collects white blood cells and tumor samples from up to 7,000 cancer patients and healthy volunteers. The cells are used in the lab to grow large numbers of immune cells that may one day be given back to patients as experimental treatments. Participants do not receive …

This study looks at whether using a physical activity questionnaire, along with exercise coaching and self-monitoring, can help breast and colon cancer survivors become more active and spend less time sitting. About 20 survivors aged 50 and older who finished their main cancer tr…

This study is testing a new system that combines aging, mental health, and social needs checks for cancer patients aged 65 and older. The goal is to help doctors provide care that fits each patient's life. About 35 people with different cancers will try it during their first visi…

This study uses a special MRI technique to measure the amount of saturated fat in breast tissue without needing a biopsy. Researchers want to see if women with breast cancer have higher levels of saturated fat in their breasts compared to women with non-cancerous lumps. About 190…

This study tests a program called Potlako+ that combines community education, help for healthcare workers, and patient guides to speed up cancer detection and treatment. About 874 adults in Botswana with possible cancer symptoms will take part. Half of the communities get the pro…

This study is observing nearly 3,000 people newly diagnosed with breast cancer in Latin America. Researchers are collecting information on how the cancer is diagnosed, what treatments are used, and how patients respond over time. The goal is to better understand real-world care p…

This study looks at pregnancy and fertility in women who had breast cancer. It includes 22,000 women aged 18 to 50 at diagnosis. Researchers will track how many get pregnant, whether naturally or with help, and check the health of their babies. The goal is to better inform patien…

This study looks at 100 women with breast cancer who are taking a type of drug called a CDK4/6 inhibitor. The goal is to find genetic and blood markers that can predict which patients might have severe side effects or not get enough benefit from the drug. By understanding these m…

This study looks at survival rates for people with cancers like melanoma, breast, colon, and lung cancer using data from Russian cancer registries. Researchers will analyze records from 100,000 patients to see how long they live after diagnosis. The goal is to better understand c…

This study tests a new tool called VascuLens 2.0, which uses a mixed reality headset to project a patient's blood vessel map onto their body before surgery. The goal is to help surgeons make more accurate markings for DIEP flap breast reconstruction, potentially reducing surgery …

This study looks at whether a physical exercise program can prevent heart damage in breast cancer patients receiving a type of chemotherapy called anthracycline. About 70 participants will be followed using heart scans and blood tests to see if exercise helps maintain heart funct…

This study aims to create a repository of biological samples—such as tumors, blood, and urine—from 500 adults with breast, ovarian, or uterine cancer, plus some of their relatives. Researchers will use these samples in future studies to understand DNA changes that drive cancer. P…

This study was designed to see if combining an immunotherapy drug (avelumab) with aspirin could help the immune system fight triple-negative breast cancer, a type that doesn't respond to hormone therapy. It planned to enroll women aged 18 and older with confirmed triple-negative …

This study aims to improve health literacy among women who are about to leave jail. About 279 participants will receive education on cervical and breast cancer, contraception, and sexually transmitted diseases. The goal is to empower them with knowledge to make healthier choices …

This observational study follows 2,000 young women (age 40 or younger) with breast cancer to understand how having children after diagnosis affects their survival and disease progression. It also checks the growth and health of their children. The goal is to gather knowledge, not…

This study tests a new imaging tool called HyperSight that takes clearer, faster 3D scans during radiation therapy. The goal is to see if these scans are good enough to help doctors adjust treatment more accurately for cancers of the head/neck, breast, lung, stomach, or pelvis. A…

This study aimed to see if contrast-enhanced ultrasound (CEUS) could predict whether triple negative breast cancer patients are responding to chemotherapy and immunotherapy earlier than standard MRI or CT scans. The study was withdrawn before enrolling any participants, so no res…

This study collects information from multiple hospitals about breast cancer in transgender and gender-diverse adults. Researchers will look at how the cancer was found, what risk factors were present, what treatments were used, and how well patients did over time. The goal is to …

This study looks at long-term fertility in young women treated for breast cancer. It follows 132 patients who had chemotherapy, some with and some without a procedure to freeze eggs beforehand. The goal is to see how many become pregnant and give birth years later, helping doctor…

This study was designed to see if an online navigation program helps breast cancer patients access supportive care services more easily than traditional in-person help. Participants would have been assigned to either online or in-person support for 4 weeks and then surveyed about…

This study looks at how the area around a tumor changes during chemotherapy in people with HER2-positive breast cancer. Researchers will take samples before, during, and after treatment in 30 patients who are getting chemo before surgery. The goal is to understand these changes b…

This study looks at whether a special type of breast scan (molecular breast imaging) can predict how well chemotherapy is working in women with invasive breast cancer. Researchers will compare scan results taken before, during, and after treatment. The goal is to help doctors pla…

This study looks at whether brain scans and spinal fluid tests can find early signs of brain cancer in people with HER2+ breast cancer. About 9 participants will get these tests even if they have no symptoms. The goal is to see if this approach is practical and could lead to earl…

This study brings together 15 healthcare experts to agree on the best ways to care for skin during breast cancer treatment. Skin problems from chemotherapy, radiation, and other therapies are common and can be serious. The goal is to create simple, clear guidelines that help prev…

This study aims to understand how much information people can remember about their own cancer screening and diagnosis. Researchers will test whether giving extra time or resources helps people recall more accurate details. The study was withdrawn before enrolling any participants…

This study looks at whether a simple blood test that tracks cancer DNA (ctDNA) can help doctors decide when to switch treatments for people with stage IV breast cancer. The goal is to see if changing therapy earlier, based on the blood test, can keep the cancer under control long…

This study follows over 1,300 women aged 40 or younger who were just diagnosed with breast cancer. Researchers collect surveys, blood samples, and tumor tissue to learn about the disease, treatment side effects, and emotional challenges over at least 10 years. The goal is to bett…

This early-phase study tests a new radioactive tracer called FTT for PET scans in 30 people with known or suspected breast cancer. The tracer aims to highlight a protein called PARP-1 in tumors, which may help doctors see cancer more clearly and track how well treatment is workin…

This study looks at medical records from routine care to see how Palbociclib (a targeted therapy) is used in people with a certain type of advanced breast cancer (HR+/HER2-). Researchers want to understand how long patients stay on treatment and whether it delays the need for che…

This study follows 200 women with breast cancer who are receiving doxorubicin and/or trastuzumab to see how these drugs affect heart function over time. Researchers will use echocardiograms, blood tests, and surveys to track changes and explore links to medical history and social…

This study looks for brand-new gene changes that appear in a child but not in their parents, which might raise the risk of certain cancers. Researchers will compare DNA from cancer patients and their healthy parents to spot these changes. The goal is to better understand cancer r…

This study looks at whether it is safe and possible for young women with early breast cancer to freeze their eggs or embryos before starting chemotherapy. The goal is to help preserve their ability to have children later. About 140 women aged 18 to 38 will take part, and research…

This study planned to test a new way to treat very small breast cancers by freezing them (cryoablation) during a biopsy. It was designed for women aged 60 or older with tumors 1 cm or smaller. However, the study was withdrawn before enrolling any participants, so no results are a…

This study looks at whether women aged 70 and older with a less aggressive type of breast cancer can avoid taking hormone therapy after surgery. The goal is to see if skipping this treatment reduces side effects without increasing the risk of cancer coming back. About 100 partici…

This study looks at how genetic differences in 600 people with a high-risk breast condition called LCIS affect their response and side effects from the drug raloxifene. Participants take raloxifene for at least 90 days, and researchers analyze their DNA to find gene variations li…

This study looks at whether a cardiopulmonary exercise test (CPET) can help predict heart and lung function in women with HER2-positive breast cancer who have mild heart problems from their treatment. About 23 women will do a special exercise test to measure oxygen use. The goal …

This study looks at stored tumor tissue and blood samples from 22 women with early breast cancer to find clues that might predict if the cancer will spread to the brain. Researchers will analyze genes in the tumor and measure certain proteins in the blood. The goal is to better i…

This study looks at why women in the Hauts-de-France region of France may wait longer to start breast cancer treatment, which could explain higher death rates there. Researchers will track 500 women recently diagnosed with invasive breast cancer, measuring delays from first sympt…

This study looks at whether a peer navigator program can help African-American women who have finished breast cancer treatment better understand and follow their survivorship care plans. About 145 women who are 1-12 months past treatment will be randomly assigned to receive peer …

This study looks at ways to help people who have inherited gene changes that raise cancer risk. The goal is to see if certain tools can help them follow recommended cancer screening and prevention steps, and also share their genetic test results with family members. About 720 adu…

This study follows 810 women aged 18-45 with early-stage breast cancer to see how treatment affects their menstrual cycles and quality of life. Researchers want to learn what factors lead to early menopause after cancer therapy. The goal is to better understand and predict these …

This study gathers information from 100 adults with breast, lung, gastrointestinal cancer, or multiple myeloma. Participants complete weekly online surveys about their symptoms and treatment experience for at least 12 weeks. The goal is to understand how symptoms change over time…

This study follows 500 people who had early-stage breast cancer (stage 0 to IIIC) to learn about their long-term health, quality of life, and any late side effects from treatment. Researchers will also study blood and tumor samples to understand how the immune system fights breas…

This study looks at how exercise affects the gut microbiome (the bacteria living in your gut) and whether those changes help reduce fatigue and other symptoms in breast cancer survivors. About 126 women who have finished primary treatment for breast cancer and still feel tired wi…

This study gathers medical information and tumor samples from 200 men with breast cancer to help doctors learn more about the disease. It includes a look back at past cases (1990-2010) and a registry for new patients over 30 months. The goal is to understand how the disease behav…

This study looks at 1,400 women with early breast cancer whose tumors could not be felt. It compares two methods used during surgery to find and remove these hidden tumors: one uses a radioactive injection (ROLL), the other uses a tiny magnetic seed. The goal is to see which meth…

This study collects DNA from over 21,000 New York cancer patients to look for inherited gene changes linked to several cancer types. It is an exploratory project that does not offer treatment but aims to find clues for future research. Participants include people with breast, col…

This study tests a program called IGNITE-TX that uses a website and a genetic family navigator to help relatives of people with hereditary cancer get free genetic counseling and testing. It involves 205 adults who have a known cancer gene mutation and their at-risk family members…

This study collects blood, tissue, and saliva samples from 7,000 people with and without breast cancer. Researchers will use these samples to study what causes breast cancer and find better ways to prevent, diagnose, and treat it. No direct treatment is given; this is a tissue ba…

This study planned to give high doses of vitamin D to women with breast cancer before their surgery to see how it affected cancer cells. Researchers wanted to measure changes in certain proteins and receptors linked to cancer growth. The study was withdrawn before any participant…

This study looks at whether a special ultrasound technique can help doctors decide which armpit lymph nodes need to be removed in breast cancer patients who have already had chemotherapy. About 97 women with breast cancer that spread to their armpit lymph nodes will take part. Th…

This study tests whether a new total-body PET scanner can improve cancer imaging for people with prostate cancer, breast cancer, or neuroendocrine tumors. Nine participants will receive one of three FDA-approved imaging agents to see how well the scanner captures tumor activity. …

This study uses advanced MRI scans to see how chemotherapy changes the brain in women aged 65 and older with early-stage breast cancer. Researchers will compare brain images and thinking tests taken before and after treatment. The goal is to better understand why some older patie…

This study looks at whether a patient navigator—a person who helps guide patients through the healthcare system—can improve timely follow-up after an abnormal breast imaging result. The study includes 196 people who had an abnormal screening mammogram and had not yet completed di…

This study looks at whether it is safe for people with breast tissue expanders to have an MRI scan. The main goal is to see if the MRI causes any heating, burning, or pain near the expander. About 68 people will take part, and if at least 50 scans are completed without problems, …

This study looks at whether regular high-intensity interval training (HIIT) can improve how breast cancer patients respond to chemotherapy before surgery. About 55 patients will either follow a personalized exercise program or continue their usual activity. Researchers will analy…

This study explores whether a computer algorithm called ENLIGHT can help choose approved drugs for people with advanced breast cancer that has stopped responding to treatment. About 175 adults with triple-negative or hormone-resistant breast cancer will have their tumor tested. B…

This study tests whether a special imaging system (pFGS) and 3D mammogram views can help surgeons see and remove all cancer during a partial mastectomy, reducing the need for a second surgery. About 175 women with breast cancer will take part. The main goal is to check safety and…

This study follows 253 adults aged 70 and older with early-stage breast cancer to learn how doctors make treatment decisions and how well patients stick to hormone therapy. Researchers will survey participants about barriers to care and treatment patterns. The goal is to find way…

This observational study looks at how diet, activity, and lifestyle factors relate to muscle strength, heart function, and overall outcomes in postmenopausal women treated for early-stage breast cancer with a specific type of chemotherapy. Researchers will measure heart and muscl…

This study follows 403 women with early-stage breast cancer to see how chemotherapy affects their heart, ability to exercise, and fatigue levels. Researchers compare these women to people without cancer to better understand long-term side effects. The goal is to gather knowledge,…

This study tests a new imaging method using a radioactive tracer called [18F]ISO-1 to measure sigma-2 receptors in breast cancer. These receptors are linked to how fast cancer cells multiply. About 30 adults with known or suspected breast cancer will receive a PET/CT scan to see …

This study tests whether a campaign featuring real stories from cancer survivors (Lived Experience Communication Campaign) can encourage more people in rural Tamil Nadu to get screened for oral, breast, and cervical cancers compared to standard awareness methods. About 1,120 men …

This study looks at how breast cancer treatment might change brain functions like attention, memory, and emotional control. Researchers are testing a new set of evaluations called the SAE Battery on 187 women aged 40-75 with early-stage breast cancer. The goal is to see if this b…

This study compares personalized mammography screening based on individual risk factors (genetics, family history, lifestyle) with standard biennial screening in 2200 women aged 50-67. The goal is to see if low-risk women accept longer intervals between mammograms (4 years instea…

This study looked at 197 breast cancer patients to compare survival between those whose tumors stopped responding to estrogen (ER loss) and those with triple-negative breast cancer. Researchers used a special PET scan to track estrogen receptors. The goal was to understand how th…

This study looks at how ribociclib, a targeted therapy, is actually used in everyday medical practice for women with a certain type of advanced breast cancer (HR+/HER2-). Researchers will follow about 1,000 women in France to see what doses and hormone therapy combinations doctor…

This study looks at whether breast cancer patients lose muscle outside the radiation area and if that loss is linked to fatigue. Twenty women will complete fatigue questionnaires and get CT scans before, during, and after radiotherapy. The goal is to understand how radiation affe…

This study compares two types of radiation therapy for women with early-stage breast cancer after lumpectomy. One group receives standard CT-guided radiation, and the other receives MRI-guided radiation using a special machine called an MRI-Linac. The goal is to see if the MRI-gu…

This study looks back at medical records of 1,950 breast cancer patients to build a tool that predicts whether lymph nodes are cancer-free after chemotherapy. The goal is to identify patients who could safely have a less invasive sentinel node biopsy instead of full lymph node re…

This study tests a personalized approach to treat high-risk breast cancer before surgery. Researchers use genetic testing of the tumor to choose the best drugs for each patient. The goal is to improve response and understand why some tumors resist treatment. About 200 adults with…

This study looks at how breast cancer treatment affects quality of life in women of different ages. Researchers will ask 650 women with early-stage breast cancer to fill out questionnaires about their health and well-being. The goal is to understand age-related differences in rec…

This study tests whether a simple ultrasound-guided needle biopsy can accurately tell if breast cancer has been completely wiped out by chemotherapy, compared to the standard method of checking during surgery. About 43 women with aggressive breast cancers (triple negative or HER2…

This study collects and stores breast tumor tissue from 600 patients who took part in the TAILORx trial. Researchers will analyze the samples to find biological markers that may predict whether cancer will come back or resist hormone therapy or chemotherapy. No new treatments are…

This study looks at tumor samples from over 3,000 people with advanced cancers to find specific genetic markers (biomarkers). The goal is to help doctors choose which targeted therapy clinical trials might work best for each patient. It does not test a new treatment itself, but a…

This study looks at whether giving breast cancer patients a 3D printed model of their breast helps them feel more confident about their surgery choices. About 20 women will take part, with some getting the 3D model and others getting standard scans. The goal is to see if the mode…

This study looks at how regular exercise might change the biology of breast tumors in women with early-stage breast cancer. Researchers will compare tumor samples from women who exercise regularly with those who do not. The goal is to learn more about exercise's effects on cancer…

This study looks at whether screening for social needs (like food or housing), connecting survivors with community health workers, and training clinic staff on anti-racism can improve quality of life for Black breast and prostate cancer survivors. About 1,100 survivors in Washing…

This study looks at whether people with HER2-positive breast cancer can safely have fewer heart check-ups while taking trastuzumab (a targeted therapy). Usually, patients get regular heart scans to watch for side effects. The study will track how many patients develop serious hea…

This study looks at whether it is safe to avoid removing armpit lymph nodes in patients with aggressive breast cancer types (HER2+ or triple-negative) who still have cancer in those nodes after chemotherapy. Researchers will track 600 patients over 3 years to see how many develop…

This study looks at how well the shoulder muscle works after breast reconstruction using a minimally invasive technique. Researchers will measure muscle strength and function before surgery and at 3, 6, and 12 months after. The goal is to see if the muscle returns to its normal s…

This study tests whether a genetic marker (BRCA-like) can predict which chemotherapy combination works best for people with advanced triple-negative breast cancer. About 304 participants receive either carboplatin-cyclophosphamide or paclitaxel, with or without the immunotherapy …

This study looks at whether a personalized survivorship care plan can improve quality of life for breast cancer survivors. About 100 women in Southern California who have finished active treatment will take part. Researchers want to see if having a care plan reduces stress and he…

This study aims to create a model that predicts which older adults (65+) with early-stage breast cancer are more likely to experience serious side effects from chemotherapy. Researchers will look at clinical factors and blood markers to understand why some patients have more toxi…

This study looks at how different breast cancer treatment decisions affect women's quality of life and emotional distress. Researchers followed 345 women with newly diagnosed breast cancer to understand their satisfaction with treatment choices and levels of cancer-related stress…

This study looks at whether artificial intelligence (AI) can help radiologists find breast cancer earlier on mammograms. Researchers reviewed past mammograms from 785 women, comparing how well doctors detected cancer with and without AI support. The goal is to see if AI improves …

This study looks at whether a genomic test called Prosigna can help doctors and patients choose the best treatment before surgery for HR+/Her2- breast cancer. About 60 women with early-stage or locally advanced breast cancer will participate. The main goal is to see how often the…

This study tests whether sending personalized text reminders to patients and doctors can increase the number of women who get recommended breast cancer screenings. About 8,490 women aged 40-74 who are overdue for a mammogram will take part. The goal is to see if simple nudges in …

This study looks at two new models of care for people who have finished treatment for early-stage breast or colorectal cancer. The goal is to see if these models help survivors get the recommended follow-up tests and preventive care they need. About 2,450 adults from Kaiser Perma…

This study develops and tests a new arm circumference measurement device for patients who may develop lymphedema after breast cancer surgery. 35 participants (patients and nurses) will compare the new tool against a traditional tape measure to see which is more accurate, faster, …

This study looks at whether giving doctors information about a patient's genes can help them personalize chemotherapy doses and reduce severe side effects. About 860 adults with certain cancers (like breast, gastrointestinal, or head and neck) will be randomly assigned to have th…

This study looks at whether certain genes can predict how much chemotherapy damages the ovaries in young women with breast cancer. Researchers will follow 73 women aged 18-36 for five years after treatment, measuring hormone levels and egg counts. The goal is to better understand…

This study looks at how the drug letrozole works in postmenopausal women with early-stage, hormone-sensitive breast cancer before they have surgery. About 178 participants will take letrozole for 4 to 24 weeks, and researchers will compare tumor samples taken before and after tre…

This study tests whether having healthcare providers offer breast exams and guide patients through the healthcare system can help find breast cancer earlier and start treatment faster. About 8,000 women in Ethiopia, South Africa, Nigeria, and Tanzania will take part. The goal is …

This study looks at whether a 12-week exercise program can affect certain markers in the breast tissue and blood of premenopausal women with dense breasts. Dense breast tissue is a known risk factor for breast cancer. The goal is to understand how physical activity might influenc…

This study follows 220 women who had breast cancer surgery to learn how many develop long-term pain and why. Researchers will look at medical, emotional, and lifestyle factors to find ways to prevent this pain. The goal is to help doctors better prepare patients and reduce suffer…

This study follows 238 breast cancer patients to see how chemotherapy impacts their physical function, health, and quality of life over time. Researchers compare women aged 65 and older with those under 65, tracking changes from before treatment to six months after. The goal is t…

This study tracks over 1,400 breast cancer and lymphoma patients to see how chemotherapy affects memory, attention, and thinking skills. Participants are tested before treatment, after treatment, and during follow-ups. The goal is to better understand who is most at risk for cogn…

This study looks at whether an artificial intelligence (AI) program can accurately predict if early-stage breast cancer will come back. Researchers will analyze stored tumor slides from 2,200 women who had ER-positive, HER2-negative breast cancer. The AI's predictions will be com…

This study follows women who are cancer-free at least three years after finishing early breast cancer treatment. Researchers want to learn how things like the type of cancer, treatments received, and side effects during treatment may affect quality of life and daily function year…

This study planned to test whether giving methadone during breast reconstruction surgery could reduce the need for other painkillers afterward. It was designed for women having breast reconstruction after mastectomy. However, the study was withdrawn before enrolling any participa…

This study looks at how well sentinel lymph node biopsy finds leftover cancer cells after chemotherapy in women with locally advanced breast cancer. About 162 women who had chemotherapy and whose lymph nodes seemed cancer-free will get this biopsy. The goal is to see how often th…

This study looks at four different breast imaging techniques—MRI, digital mammography, ultrasound, and PET scans—to see how well they work together to determine the size and spread of breast cancer. About 400 women recently diagnosed with breast cancer will be scanned before surg…

This study is testing a new genetic test (called Gersom panel) in 4,000 people with breast, ovarian, or colorectal cancer. The goal is to see if the test can accurately find inherited genetic risks and tumor mutations that might guide treatment choices. Participants provide blood…

This study looks at whether proton beam radiation causes less damage to the heart than standard photon radiation in people with left-sided breast cancer. About 60 participants will receive either proton or photon therapy, and their hearts will be checked with MRI scans. The goal …