New drug combo aims to slow advanced breast cancer
NCT ID NCT04650581
First seen Jan 29, 2026 · Last updated Apr 29, 2026 · Updated 15 times
Summary
This phase 3 trial tests whether adding the experimental drug ipatasertib to standard hormone therapy (fulvestrant) can slow the growth of advanced ER-positive, HER2-negative breast cancer. The study enrolls 250 people whose cancer worsened after initial treatment with a CDK 4/6 inhibitor and an aromatase inhibitor. Participants are randomly assigned to receive either the combination or fulvestrant alone, and researchers track how long the cancer stays under control.
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Alfred Hospital
Melbourne, Victoria, 3004, Australia
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Algoma District Cancer Program
Sault Ste. Marie, Ontario, P6B 0A8, Canada
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Allan Blair Cancer Centre
Regina, Saskatchewan, S4T 7T1, Canada
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Auckland City Hospital
Auckland, 1023, New Zealand
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BCCA - Cancer Centre for the Southern Interior
Kelowna, British Columbia, V1Y 5L3, Canada
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BCCA - Fraser Valley Cancer Centre
Surrey, British Columbia, V3V 1Z2, Canada
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BCCA - Vancouver Cancer Centre
Vancouver, British Columbia, V5Z 4E6, Canada
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CHA-Hopital Du St-Sacrement
Québec, Quebec, G1S 4L8, Canada
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CHUM-Centre Hospitalier de l'Universite de Montreal
Montreal, Quebec, H2X 3E4, Canada
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Canberra Hospital
Garran, ACT 2605, Australia
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Centre Integre de Sante et de Services Sociaux
Greenfield Park, Quebec, J4V 2H1, Canada
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Fiona Stanley Hospital
Murdoch, Western Australia, 6150, Australia
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Frankston Hospital
Frankston, Victoria, 3199, Australia
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Gosford Hospital
Gosford, New South Wales, 2250, Australia
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Juravinski Cancer Centre at Hamilton Health Sciences
Hamilton, Ontario, L8V 5C2, Canada
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Kingston Health Sciences Centre
Kingston, Ontario, K7L 2V7, Canada
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Lake Macquarie Private Hospital
Gateshead, New South Wales, 2324, Australia
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London Regional Cancer Program
London, Ontario, N6A 5W9, Canada
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Macquarie University Hospital
Macquarie University, New South Wales, 2109, Australia
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Ottawa Hospital Research Institute
Ottawa, Ontario, K1H 8L6, Canada
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QEII Health Sciences Centre
Halifax, Nova Scotia, B3H 1V7, Canada
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Regional Health Authority B, Zone 2
Saint John, New Brunswick, E2L 4L2, Canada
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Royal Brisbane and Womens Hospital
Herston, 4029, Australia
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Royal Victoria Regional Health Centre
Barrie, Ontario, L4M 6M2, Canada
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Saskatoon Cancer Centre
Saskatoon, Saskatchewan, S7N 4H4, Canada
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Shoalhaven Cancer Care Centre
Nowra, New South Wales, 2541, Australia
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Southern Highlands Cancer Centre
Bowral, New South Wales, 2576, Australia
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St John of God Bunbury
Bunbury, Western Australia, 6230, Australia
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Stronach Regional Health Centre at Southlake
Newmarket, Ontario, L3Y 2P9, Canada
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Sunshine Coast University Hospital
Birtinya, Queensland, 4575, Australia
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Sunshine Hospital
St Albans, Victoria, 3021, Australia
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The Northern Hospital
Epping, Victoria, 3076, Australia
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Thunder Bay Regional Health Sciences Centre/
Thunder Bay, Ontario, P7B 6V4, Canada
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Toowoomba Hospital
Toowoomba, Queensland, 4350, Australia
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University Health Network
Toronto, Ontario, M5G 2M9, Canada
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Victorian Breast and Oncology Care
East Melbourne, Victoria, 3002, Australia
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Wellington Cancer Centre, Wellington Hospital
Wellington, 2, New Zealand
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William Osler Health System
Brampton, Ontario, L6R 3J7, Canada
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Windsor Regional Cancer Centre
Windsor, Ontario, N8W 2X3, Canada
Conditions
Explore the condition pages connected to this study.