New drug duo aims to stall Hard-to-Treat breast cancer
NCT ID NCT06125522
First seen Oct 31, 2025 · Last updated May 23, 2026 · Updated 33 times
Summary
This study tests two oral medicines, vepdegestrant and samuraciclib, taken daily at home by adults with advanced or metastatic ER+ breast cancer that no longer responds to prior treatments. The goal is to see if the combination is safe and can shrink tumors or slow cancer growth. Participants continue until the cancer progresses or side effects become too severe.
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Barnes-Jewish Hospital
St Louis, Missouri, 63110, United States
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Centre Georges François Leclerc
Dijon, Côte-d'or, 21079, France
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Clinical and Translational Research Unit (CTRU)
Palo Alto, California, 94304, United States
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Fondazione IRCCS San Gerardo dei Tintori
Monza, Lombardy, 20900, Italy
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Fondazione Policlinico Universitario Agostino Gemelli IRCCS - Università Cattolica del Sacro Cuore
Roma, 00168, Italy
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Highlands Oncology Group
Fayetteville, Arkansas, 72703, United States
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Highlands Oncology Group
Rogers, Arkansas, 72758, United States
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Highlands Oncology Group
Springdale, Arkansas, 72762, United States
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Institut Jules Bordet
Anderlecht, Bruxelles-capitale, Région de, 1070, Belgium
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Memorial Hospital East
Shiloh, Illinois, 62269, United States
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Siteman Cancer Center - North County
Florissant, Missouri, 63031, United States
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Siteman Cancer Center - Shiloh
Shiloh, Illinois, 62269, United States
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Siteman Cancer Center - South County
St Louis, Missouri, 63129, United States
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Siteman Cancer Center - St Peters
City of Saint Peters, Missouri, 63376, United States
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Siteman Cancer Center - West County
Creve Coeur, Missouri, 63141, United States
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Stanford Women's Cancer Center
Palo Alto, California, 94304, United States
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UCHealth - Medical Center of the Rockies
Loveland, Colorado, 80538, United States
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UCHealth Greeley Hospital
Greeley, Colorado, 80634, United States
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UCHealth Harmony
Fort Collins, Colorado, 80528, United States
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UCHealth Poudre Valley Hospital
Fort Collins, Colorado, 80524, United States
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Washington University School of Medicine - Siteman Cancer Center
St Louis, Missouri, 63110, United States
Conditions
Explore the condition pages connected to this study.