BREAST CANCER

This early study tested whether using high-intensity focused ultrasound (HIFU) before or after the immunotherapy drug pembrolizumab could help the immune system better attack metastatic breast cancer. Only 13 people took part before the study was stopped early. The main goal was …

This study tested a new drug called TAK-500, alone or with pembrolizumab, in 61 adults with advanced solid tumors like pancreatic, liver, and lung cancer. The goal was to check safety and see if the drug could shrink tumors. The trial was terminated early, so results are limited.

This study tested a drug called abemaciclib in people with a specific type of advanced breast cancer (triple negative, retinoblastoma-positive) that had spread. The goal was to see if the drug could shrink tumors. The study was stopped early after enrolling 27 participants, so re…

This study tested a new drug called azenosertib combined with two standard cancer drugs (carboplatin and pembrolizumab) in people with metastatic triple-negative breast cancer. The goal was to find the safest dose and see if the combination could shrink tumors. Only 7 people took…

This study tested a radioactive drug called [225Ac]-FPI-1434 in people with advanced solid tumours that had not responded to standard treatments. The goal was to find a safe dose and see if it could shrink tumours. The trial was stopped early, so results are limited. Participants…

This early-stage study tested an experimental oral drug called amcenestrant, alone or with other cancer drugs, in 136 postmenopausal women with advanced estrogen receptor-positive (ER+) breast cancer that had spread. The goal was to find safe doses and see if the drug could shrin…

This study tested a new hormone therapy, amcenestrant, at two different doses against the standard drug letrozole in postmenopausal women with a common type of early breast cancer (ER+/HER2-). The goal was to see if amcenestrant could better slow tumor growth before surgery. The …

This study tested a new drug (LY2780301) combined with standard chemotherapy (paclitaxel) in people with advanced breast cancer that had spread or couldn't be removed. The goal was to find the best dose and see if the combination could shrink tumors. The trial was stopped early, …

This study tested an experimental drug called SAR443216 in 44 adults with advanced HER2-positive solid tumors (like breast, lung, or stomach cancer) that had stopped responding to other treatments. The goal was to find a safe dose and see if it could shrink tumors. However, the t…

This study tested a new drug called NUV-868, alone or with other cancer drugs (olaparib or enzalutamide), in 82 adults with advanced solid tumors like ovarian, pancreatic, prostate, or breast cancer. The main goals were to check safety and find the right dose. The trial was stopp…

This study looked at whether combining mammograms and breast MRIs could help doctors better identify patients with early-stage breast cancer (DCIS) who could be treated with a single dose of radiation during surgery. The goal was to see if this approach could reduce the need for …

This study tested a combination of two oral drugs (BKM120 and lapatinib) in 24 adults with advanced HER2-positive breast cancer that had stopped responding to trastuzumab. The goal was to find the safest dose and see if the combo could shrink tumors. The trial was terminated earl…

This study tested a combination of two drugs, abemaciclib and elacestrant, in women with a certain type of breast cancer (HR+/Her2-) that had spread to the brain. The goal was to see if the drugs were safe and could shrink or control brain tumors. Only 5 patients were enrolled be…

This study tested a new drug (TQB3912) combined with standard treatments for people with advanced HR-positive, HER2-negative breast cancer. The goal was to find the safest dose and see if the combination could shrink tumors or slow the disease. Only 8 people took part before the …

This study looked at menopausal women over 50 with small breast cancers (less than 10 mm) to see if removing armpit lymph nodes during surgery is necessary. The goal was to find out if skipping this step affects survival or cancer coming back in the armpit area. The study was sto…

This study aimed to compare two types of radiation therapy given after breast-conserving surgery for early-stage breast cancer: 3D conformal radiation therapy and internal radiation (brachytherapy). The goal was to see which method better kills remaining cancer cells while sparin…

This study tested a combination of two drugs—pembrolizumab (an immunotherapy) and mifepristone (a hormone blocker)—in people with advanced HER2-negative breast cancer. The goal was to see if the combination could shrink tumors. The study included 24 participants and was stopped e…

This study tested a new drug, amcenestrant, combined with palbociclib against the standard letrozole plus palbociclib for people with a common type of advanced breast cancer (ER+/HER2-). The goal was to see if the new combo could delay cancer growth longer. The trial was stopped …

This study tested a new drug, GDC-0084, combined with the standard drug trastuzumab (Herceptin) in 17 people with HER2-positive breast cancer that had spread to the brain. The goal was to see if the combination could shrink or control brain tumors. The trial was terminated early,…

This study tested a new drug, amcenestrant, against an older drug, tamoxifen, in people with hormone receptor-positive early breast cancer who had to stop their initial hormone therapy due to side effects. The goal was to see if amcenestrant could better prevent the cancer from c…

This study tested a drug called neratinib, alone or with another drug (fulvestrant), in 21 people with a specific type of advanced breast cancer (HER2-positive and ER-positive). The goal was to see if the combination could slow cancer growth better than neratinib alone. The study…

This early-stage study tested a new drug called TAS2940 in 29 people with advanced solid tumors (like lung, breast, or brain cancer) that had certain genetic changes (EGFR or HER2). The goal was to find a safe dose and see if it could shrink tumors. The trial was stopped early, s…

This early-phase study tested a new drug (infigratinib) combined with tamoxifen for people with a specific advanced breast cancer that is hormone receptor-positive, HER2-negative, and has changes in the FGFR gene. The main goal was to find a safe dose by monitoring side effects. …

This study tested a new, fast, and low-cost MRI method to screen for breast cancer in women with dense breasts or moderate risk. The goal was to see if this MRI could find cancers earlier and more accurately than standard mammograms. The study enrolled 166 women and compared MRI …

This study aimed to see if a new type of ultrasound, called acoustic angiography, could better detect breast and thyroid cancers compared to standard ultrasound. The plan was to scan 45 people, including healthy volunteers and patients scheduled for biopsies. However, the study w…

This study tested whether a special MRI technique called DWIBS can better identify suspicious breast lesions found on mammograms and ultrasounds. Researchers aimed to see if it could tell cancerous from non-cancerous growths and possibly reduce false alarms that lead to unnecessa…

This study tested a special fluorescent dye (PD G 506 A) and camera system to help surgeons see leftover breast cancer cells in real-time during breast-conserving surgery. The goal was to help surgeons remove all the cancer in one operation, reducing the need for patients to have…

This study tested whether a technique called axillary reverse mapping with lympho-venous bypass could prevent lymphedema (arm swelling) in people having lymph nodes removed for breast cancer or melanoma. The approach aimed to reroute lymph fluid to reduce swelling. The study was …

This study looked at whether giving radiation to the brain early could prevent cancer from spreading there in people with HER2-positive breast cancer that had already spread to other organs. All participants were receiving trastuzumab (Herceptin) plus chemotherapy. The study was …

This study tested whether the sleep medication suvorexant (20 mg) could help breast cancer survivors who have trouble sleeping. Participants were postmenopausal women currently taking hormone therapy. The trial compared suvorexant to a placebo, with both groups also learning abou…

This study tested a program to improve quality of life for young African American women who finished treatment for early or late-stage breast cancer. About 27 women took part in either the program or a comparison group. The goal was to see if the program helped with physical, emo…

This study tested if a continuous infusion of the numbing medicine ropivacaine into the surgical wound after mastectomy could reduce pain and speed up recovery compared to a placebo. The goal was to help patients get back to daily activities sooner and lower the risk of chronic p…

This study tested a digital app that appears on the phone's lock screen to encourage physical activity in cancer survivors. Participants used the app for 3 months and wore a Fitbit to track activity. The goal was to see if the app could increase exercise and improve blood vessel …

This study tested a cream called Dermaprazole to prevent skin irritation (radiation dermatitis) in breast cancer patients after mastectomy. Only 3 women joined before the study was stopped. The goal was to see if the cream was safe and could reduce skin redness, peeling, and swel…

This study tested a special donor nipple graft for women who had breast reconstruction after breast cancer. The goal was to see if the graft heals safely and how long it takes. Only 6 people took part before the study was stopped early.

This study tested a digital health app called medidux™ to see if it could help track and reduce serious side effects in people with HER2-positive breast cancer undergoing chemotherapy and targeted therapy. The trial planned to enroll 196 adults but was terminated early. The main …

This study tested whether applying tranexamic acid (TXA) directly to the surgical area during breast removal and reconstruction reduces bleeding and fluid collections. It involved 23 women at high risk for or with breast cancer. The goal was to improve recovery and lower the chan…

This study looked at whether a mechanical stimulation technique could reduce pain and improve shoulder function better than standard massages in women who had a total mastectomy and lymph node removal for breast cancer. About 80 participants were planned, but the study was stoppe…

This study looked at whether wearing a chest bandage after mastectomy could reduce the number of times doctors need to drain fluid buildup (seroma). It included 60 women who had already needed at least two large drainages. Half wore a bandage plus got drainage, the other half onl…

This study looked at 42 women with advanced breast cancer who had chemotherapy before surgery. Researchers compared three imaging tests—PET-CT, ultrasound, and MRI—to see which one best measures leftover tumor size. The goal was to help doctors choose the right test for planning …

This study looked at whether a new, simpler consent process could help compare three standard chemotherapy plans for triple-negative breast cancer (TNBC). TNBC is an aggressive breast cancer that lacks certain hormone receptors, and doctors don't agree on the best chemotherapy. T…

This research registry looks at the health, well-being, and needs of people who survived cancer as young adults (diagnosed between ages 18 and 39). It tracks levels of anxiety, depression, social support, and financial distress by having participants fill out online surveys every…

This study looked at genetic and protein changes in 749 adults with breast cancer to find patterns that might predict how the disease behaves. Researchers measured gene activity and linked it to patient and tumor features. The study was stopped early, so results are limited.

This study looked at how a single round of chemotherapy affects the muscles of women with breast cancer. Researchers compared three different drug combinations to see which caused more muscle changes. Only 5 people took part before the study was stopped early, so the results are …

This study looked at whether standard doses of hormone-lowering pills (aromatase inhibitors) work differently in overweight or obese postmenopausal women with breast cancer compared to normal-weight women. Researchers planned to measure changes in a tumor growth marker (Ki67) aft…

This study looked at whether giving women with breast cancer extra emotional and practical help early on could improve their chances of returning to work. It included 128 women who had surgery and chemotherapy. The study was stopped early, so results are limited.

This study looked at whether giving a short course of immunotherapy (atezolizumab, alone or with other drugs) before standard treatment could boost the immune system's attack on early-stage breast cancer tumors. It included people with triple-negative or HER2-positive breast canc…

This study looked at breast cancer stem cells, which are thought to be the root of tumor growth and resistance to standard treatments like chemotherapy. Researchers collected tumor samples and blood from 56 women before, during, and after chemotherapy to track how these stem cell…

This study looked at 289 people with early-onset breast, ovarian, colorectal, or pediatric cancers, plus those with multiple tumors. Researchers used a special test to check 200 genes for inherited mutations that standard tests might miss. The goal was to better understand why th…

This study aimed to understand how chemotherapy impacts the ability to have children in young women (ages 18-37) with breast cancer. Researchers measured ovarian reserve using hormone levels and follicle counts before, during, and up to 24 months after treatment. The goal was to …

This study aimed to track heart function changes in breast cancer patients during chemotherapy, using detailed heart imaging. Only 2 people enrolled before the study was stopped early. The goal was to find early signs of heart damage so doctors could start protective measures lik…

This study looked at whether taking high doses of vitamin D could change certain genes in breast cancer tumors, and if a woman's weight affected those changes. It included 41 women with breast cancer who had not yet started treatment. The study was stopped early, so results are l…

This study aimed to see if using an electronic system to track symptoms could improve quality of life for people with early-stage breast or colorectal cancer receiving chemotherapy. Only 8 participants were enrolled before the trial was stopped early. The main goal was to measure…