BREAST CANCER

This study looks at women with breast cancer that has spread to lymph nodes in the armpit, found before surgery. Normally, doctors remove many lymph nodes, which can cause arm swelling and pain. The trial tests if removing only the first few affected nodes works just as well for …

This trial tests a program called ONLOOP that reminds adult survivors of childhood cancer to get important screening tests. These tests can catch serious late effects like heart disease or second cancers early. About 900 survivors in Ontario will be randomly assigned to use ONLOO…

This early-stage trial tests a new drug called HRS-6209 combined with standard hormone therapies (fulvestrant or letrozole) in people with a certain type of advanced breast cancer (HR-positive, HER2-negative). The main goals are to check safety and how the drug moves through the …

This study tests whether adding an immune-boosting drug called eftilagimod alpha to standard chemotherapy can make breast tumors disappear completely before surgery in people with early-stage HR+/HER2- breast cancer. About 50 participants will receive the drug combination, and re…

This study reviews a specific breast reconstruction surgery done at least 6 months after a mastectomy for breast cancer. Researchers will look at how satisfied patients are with the results and how safe the procedure is. The study involves 150 participants from multiple centers a…

This study explores a new surgical approach for women with early-stage breast cancer. During nipple-sparing mastectomy, if cancer is found in the nipple, doctors will remove the nipple but try to preserve the areola and rebuild a new nipple in the same surgery. About 40 women wil…

This study tests whether a 16-week supervised exercise program can help prevent heart damage in breast cancer survivors. Many breast cancer treatments can harm the heart, and this trial aims to see if regular exercise can protect it. The study will include 44 women who finished c…

This study tests whether adding radiation and a drug called axatilimab can help the immunotherapy pembrolizumab work better in people with metastatic triple-negative breast cancer (TNBC) who have already tried immunotherapy. About 34 adults with at least two measurable tumors wil…

This study tests whether adding radiotherapy before surgery to standard chemotherapy can shrink tumors more effectively in people with locally advanced breast cancer. About 50 adults with Luminal or triple-negative breast cancer that didn't shrink enough after initial chemo will …

This early-phase study tests a new combination treatment for people with advanced breast cancer that has not responded to standard therapies. The treatment uses specially engineered immune cells (TRICK-NK) given together with a targeted drug (T-Dxd). The main goals are to find th…

This study looks at 4,000 women aged 50 or younger with a common type of breast cancer. Researchers want to see if hormone therapy combined with ovarian suppression works as well as chemotherapy for certain patients. The goal is to find out who can safely skip chemo and avoid its…

This early-phase study tests a new type of cell therapy for people with HER2-positive breast cancer that has spread and stopped responding to standard treatments. Researchers take patients' own immune cells (T cells), add genes to help them recognize and kill cancer cells, and re…

This study tests a new combination of two drugs (iparomlimab and tuvonralimab) plus chemotherapy given before surgery for patients with a common type of breast cancer (HR+/HER2-). The goal is to see if this approach can eliminate all signs of cancer in the breast and lymph nodes …

This phase 3 trial tests whether an artificial intelligence (AI) model can pick a more effective combination of targeted drugs for women with HER2-positive breast cancer before surgery. About 280 women will either receive the AI-chosen therapy or the standard drug combo. The main…

This study tests a new approach for people with early-stage triple-negative breast cancer. It combines an immunotherapy drug (QL1706) with chemotherapy before surgery. The key idea is to use scans and biopsies after the first part of treatment to see who responds well. Those who …

This study compares a new drug, SHR-A1811, with a standard combination therapy (pyrotinib plus capecitabine) in 100 adults with advanced HER2-positive breast cancer that did not respond to the first-line drug trastuzumab. The goal is to see which treatment better delays cancer gr…

This study tests whether adding the immunotherapy drug toripalimab and targeted radiation to standard chemotherapy can help shrink HER2-negative breast tumors that didn't respond to initial chemo. About 110 adults with early-stage breast cancer will be split into groups receiving…

This study tests whether giving two drugs—serplulimab and trastuzumab rezetecan—before surgery can completely eliminate triple-negative breast cancer in 84 women. Participants will receive the combination as neoadjuvant therapy, and the main goal is to see how many have no cancer…

This study tests a new drug combination for women with a specific type of breast cancer (ER-positive, HER2-positive) before they have surgery. The goal is to see if using targeted drugs instead of chemotherapy can shrink or eliminate the tumor. About 42 women with stage II or III…

This study tests whether adding trilaciclib to the chemotherapy drug eribulin can protect bone marrow in people with advanced triple-negative breast cancer who have already tried at least two other chemotherapies. The goal is to reduce serious side effects like low white blood ce…

This study tests whether adding 4 cycles of the drug T-DXh can eliminate leftover cancer in women with HER2-positive breast cancer who still have disease after standard chemotherapy. About 59 participants will receive T-DXh before surgery. The goal is to see if more patients can …

This study tests two drugs (imlunestrant and abemaciclib) given before surgery to shrink estrogen-receptor-positive, HER2-negative breast tumors. About 189 women will take the pills for several weeks, and doctors will check a marker called Ki67 after 2 weeks to guide treatment. T…

This early-stage study tests whether adding a targeted drug (CDK4/6 inhibitor) to standard radiation therapy is safe and tolerable for women with a common type of high-risk breast cancer (HR+/HER2-). About 30 participants will receive the combination after surgery. Researchers wi…

This study tests a program to help women with ER-positive breast cancer in Rwanda take their daily hormone therapy pills as prescribed. The program includes education, reminders, and support. Researchers will check if it improves how well patients follow their treatment plan over…

This study tests a new three-drug combination (zanidatamab, tucatinib, and chemotherapy) in people with advanced HER2-positive breast cancer that has spread or cannot be removed by surgery. The goal is to find the safest dose and see if the combination shrinks tumors. About 24 ad…

This study looks at whether tirzepatide, a once-weekly injection, is acceptable and helpful for postmenopausal women who have had hormone-positive breast cancer and are now living with obesity. Over 6 months, 30 participants will take the medication, have monthly check-ins, and u…

This study tests a new approach for women with a common type of early breast cancer (HR+/HER2-). Instead of standard chemotherapy before surgery, some participants will receive a targeted drug (abemaciclib) plus hormone therapy, based on a gene test result. The goal is to see if …

This early-phase trial tests a new radioactive drug (177Lu-INN805) in 10 adults with advanced solid tumors like head & neck, thyroid, lung, breast, or sarcoma cancer who have not responded to standard treatments. The drug is given every 6 weeks for up to 4 cycles to find the safe…

This study tests whether a new drug, trastuzumab-rezetecan, works better than the current standard T-DXd for shrinking HER2-positive breast tumors before surgery. About 68 women with early or locally advanced breast cancer will receive one of the two drugs for 8 cycles, then have…

This study tests a personalized approach for people with HER2-positive breast cancer. After two cycles of standard treatment, those whose tumors shrink less than 40% will switch to a new drug combo (SHR-A1811 plus pertuzumab) for four more cycles before surgery. The goal is to se…

This study tests whether the drug Sacituzumab govitecan can slow down advanced triple-negative breast cancer when used as the first treatment. About 24 adults who have not had prior treatment for advanced disease will receive the drug on days 1 and 8 of each 21-day cycle. Researc…

This study tests an experimental drug called SHR-A1811 in 51 women with HER2-positive breast cancer that has spread to the brain. It aims to see if the drug is safe and can shrink or control brain tumors, including cases where cancer has reached the lining of the brain. Participa…

This study compares a new 1-week radiation schedule (ultra-hypofractionated) to the standard 3-week schedule for treating lymph nodes after breast cancer surgery. It aims to see if the shorter treatment is just as effective at preventing cancer from coming back. About 1,950 adult…

This early-phase trial tests the safety of a new drug, IM-1617, in about 175 adults with advanced solid tumors (colorectal, lung, breast, stomach, esophageal, or other cancers that have spread or can't be removed by surgery). The study first finds a safe dose, then checks how wel…

This study looks at whether a blood test that finds tiny bits of cancer DNA (ctDNA) can help catch breast cancer early if it tries to come back. People who had surgery and standard treatment for a common type of breast cancer (HR+/HER2-) will get regular blood tests. If the test …

This study tests an experimental drug called AK138D1, given alone or with another drug (ivonescimab), in people with advanced breast cancer. The goal is to see if the treatment is safe and can shrink tumors. About 286 adults aged 18 to 75 with measurable tumors and adequate organ…

This early-phase study tests a new treatment for people with metastatic breast or prostate cancer that has spread and is no longer responding to standard therapies. The treatment uses the patient's own immune cells, which are collected, coated with a special antibody (HER2Bi), an…

This early-phase study tests a drug called trastuzumab deruxtecan (T-DXd) combined with precise radiation (SRS) for people with HER2-positive breast cancer that has spread to the brain. The goal is to find the safest dose of the drug when given with radiation and to see how well …

This pilot study tests a 4-week program led by nurses and supported by general practitioners to help breast cancer survivors who also have heart disease. The program focuses on lifestyle changes like exercise, diet, and stress management. Researchers will see if the program is pr…

This study compares two different shortened radiotherapy schedules for women with breast cancer after surgery. One group receives radiation over 2 weeks (34 Gy in 10 sessions) and the other over 3 weeks (40.05 Gy in 15 sessions). The goal is to see which schedule better controls …

This study tests whether placing tiny radioactive seeds in breast tumors before chemotherapy can help the cancer disappear completely by the time of surgery. About 194 women with early-stage breast cancer will be randomly assigned to get seeds or standard care. The goal is to see…

This study looks at whether women with a low-risk type of early breast cancer (DCIS) can avoid radiation therapy after lumpectomy without a meaningful increase in cancer coming back. About 5,270 women will be grouped by a special test that predicts their risk. Those with low-risk…

This study tests whether adding the drug fluzoparib to standard treatment can help prevent breast cancer from coming back in women with early-stage breast cancer who have specific gene changes (HRR mutations). About 334 women will be split into two groups: one gets fluzoparib plu…

This study looks at how well the drug pyrotinib works and how safe it is for people with advanced HER2-positive breast cancer. About 500 adults will be observed during their normal treatment. The goal is to see how long the drug keeps the cancer from growing and to learn which pa…

This study is testing a combination of four drugs (pertuzumab, trastuzumab, palbociclib, and exemestane) given before surgery to people with triple-positive breast cancer. The goal is to see if this treatment can eliminate all cancer cells in the breast and lymph nodes by the tim…

This study tests a new two-drug combination (camizestrant and ribociclib) in 150 people with advanced hormone receptor-positive (HR+) breast cancer. Participants must have had at least 5 years of prior hormone therapy. The goal is to see how long the cancer stays under control be…

This study tests whether the drug hetrombopag can prevent or reduce low platelet counts (thrombocytopenia) caused by antibody-drug conjugate (ADC) treatments for breast cancer. About 72 adults with breast cancer will receive hetrombopag alongside their regular chemotherapy. The g…

This study looks at whether transferring healthy gut bacteria from donors (fecal transplant) can make chemotherapy and immunotherapy more effective for people with triple-negative breast cancer. About 125 participants will first provide samples to establish a baseline, then some …

This phase 3 trial tests whether giving breast cancer patients a personalized dose of tamoxifen (based on how their body processes the drug) helps them stay on treatment longer and have better outcomes. Currently, 30-50% of patients stop taking tamoxifen early due to side effects…

This study looks at how well a drug called inavolisib works in everyday medical practice for people with a specific type of advanced breast cancer (HR-positive, HER2-negative, with a PIK3CA mutation). About 100 participants will receive inavolisib combined with hormone therapy, w…

This study tests whether adding famitinib to the drug SHR-A1811 works better than SHR-A1811 alone for people with a certain type of advanced breast cancer (HR+/HER2-) that no longer responds to CDK4/6 inhibitors. About 248 women aged 18-70 will take part. The main goal is to see …

This study tests whether adding the experimental drug QL1706 to standard chemotherapy and targeted therapy works better than the usual approach for early or locally advanced HER2-positive breast cancer. About 188 adults with tumors larger than 2 cm or that have spread to lymph no…

This study tests whether Huaier granules, a traditional Chinese medicine, can help lower certain tumor markers (CEA, CA125, CA153) in people with early-stage breast cancer. About 232 participants will be randomly assigned to receive Huaier granules or not, and researchers will co…

This study tests a combination of two drugs, entinostat and oral paclitaxel, in people with a specific type of advanced breast cancer (HR-positive, HER2-negative). The goal is to see if this treatment can slow down the cancer's growth. About 50 adults who have already tried 2 to …

This study tests whether using a special PET scan (HER2-PET/CT) can help doctors personalize chemotherapy for early-stage HER2-positive breast cancer. After two cycles of treatment, the scan shows how well the tumor responds, allowing some patients to get stronger treatment and o…

This study tests whether adding a targeted drug (dalpiciclib) and hormone therapy to brain radiation can help control breast cancer that has spread to the brain. About 46 women with HR-positive, HER2-negative advanced breast cancer will receive the combination treatment. The goal…

This early-phase study tests whether adding pirfenidone to standard immunotherapy (camrelizumab) and chemotherapy can shrink tumors in 12 people with advanced triple-negative breast cancer. Participants must have already tried first-line treatment. The goal is to see how many pat…

This study is for women with early-stage HR+/HER2+ breast cancer, a type where two signals drive tumor growth. The goal is to see if giving personalized treatment before surgery can improve the chance of eliminating all cancer cells. Researchers will adjust therapy based on early…

This study tests whether adding a targeted drug called inavolisib to standard treatment can better eliminate breast cancer before surgery in people with a specific genetic mutation (PIK3CA) and HER2-positive early breast cancer. About 164 participants will receive either the stan…

This study compares two types of radiation therapy—proton and photon—given after breast cancer surgery. The goal is to see which one causes fewer side effects to the heart, lungs, skin, and other organs. About 750 women will be followed for at least a year to track complications …

This study tests if a combination of a targeted drug (CDK4/6 inhibitor) and hormone therapy can replace chemotherapy for women with a specific type of early breast cancer that is small but has high-risk features. About 2,288 participants will either receive the new drug combo or …

This phase 3 trial tests a personalized approach for people with stage II or III triple-negative breast cancer. Participants first receive 12 weeks of standard chemo plus immunotherapy. Those with a good response continue the same treatment; those with a poor response are switche…

This study looks at whether women with intermediate-risk breast cancer can safely avoid radiation therapy to the lymph nodes after surgery. About 3,100 participants will be randomly assigned to receive either standard radiation or no radiation. The goal is to see if skipping radi…

This study tests whether a grape polyphenol concentrate can help prevent heart damage in breast cancer patients receiving certain types of chemotherapy. About 120 women at high risk for heart problems will take either the grape supplement or a placebo for three months. Researcher…

This study looks at whether a combination of ribociclib and hormone therapy can work as well as chemotherapy followed by the same combination in people with a certain type of early breast cancer (HR+/HER2-). The study only includes patients whose blood tests show no signs of canc…

This study tracks about 500 postmenopausal women with a certain type of advanced breast cancer (ER+, HER2-, with an ESR1 mutation) who are taking the drug elacestrant. Researchers want to see how the drug affects quality of life, side effects, and how well it works in everyday me…

This study tests whether some people with early-stage breast cancer can safely avoid surgery after chemotherapy and radiation. Participants will be monitored with MRIs, mammograms, and blood tests to check if the cancer stays away. The goal is to see if a non-surgical approach wo…

This study tests a new cell therapy called SL-28 for people with advanced solid tumors that have not responded to standard treatments. The therapy uses donor immune cells to attack the cancer. The goal is to see if it is safe and can shrink tumors in up to 60 participants with va…

This study tests a new drug called SHR-A1811, given alone or with hormone therapy (letrozole), before surgery for early-stage breast cancer that is hormone-receptor-positive and HER2-low. About 120 women will be randomly assigned to one of three groups: the new drug plus hormone …

This study tests whether women with a specific type of early-stage breast cancer (HR-positive, HER2-positive, no lymph node spread) can safely skip chemotherapy. Instead, they would receive a combination of hormone therapy, a CDK4/6 inhibitor, and anti-HER2 drugs. The trial will …

This study aims to develop an AI model that can predict the HER2 status of breast cancer using MRI scans, potentially reducing the need for invasive biopsies. Researchers will analyze MRI images from 400 breast cancer patients to find patterns that distinguish aggressive HER2-pos…

This study is testing a new, non-invasive way to analyze DNA from nipple discharge to tell the difference between harmless and cancerous breast conditions. About 60 adults with bloody nipple discharge who are already scheduled for surgery will provide a small fluid sample before …

This study looks at whether a special ultrasound can accurately tell if breast cancer has been completely cleared from the lymph nodes after chemotherapy. About 150 women with breast cancer that has spread to their lymph nodes will have a tiny marker placed in the affected node b…

This study tests a special scanner that lets surgeons check, in real time during surgery, whether they removed all the cancer from the breast. It is for women with certain high-risk breast cancer types. If the scanner shows leftover cancer, the surgeon can remove more tissue righ…

This study is testing a new blood test that uses artificial intelligence to analyze DNA fragments in the blood. The goal is to see if it can accurately determine the stage of breast cancer and whether it has spread to lymph nodes, potentially reducing the need for surgery. The st…

This study tests a new type of MRI scanner, called Field-Cycling Imaging (FCI), to see if it can more accurately measure the size of breast tumors in people with ductal carcinoma in situ (DCIS). About 12 participants will have both a standard MRI and an FCI scan before their surg…

This study tests whether a new AI software, Kenko Breast AI+, helps doctors read breast MRI scans more accurately to diagnose breast cancer. About 200 adult women with suspected or follow-up breast cancer will participate. Researchers will compare MRI readings with and without th…

This study looks at whether mammogram and ultrasound images can predict the molecular subtype of breast cancer (like Luminal A/B, HER2-enriched, or triple-negative) without needing a biopsy. Researchers will compare imaging features to lab results from 122 women with suspected or…

This study tests a new type of PET scan (68Ga-FAPI) to see if it can find breast cancer that has spread to other parts of the body better than the standard scan. It includes 45 adults with lobular breast cancer whose standard scan was negative or unclear. If successful, this new …

This study aims to make breast cancer diagnosis faster in rural Rwanda by training non-radiologist clinicians to perform breast ultrasound. Currently, only specialists at city hospitals can do these scans, causing delays. The project will compare two support strategies—live remot…

This study will check if two blood test measurements (AST/ALT ratio and MPV/platelet count ratio) are different in people with breast cancer compared to healthy people. Researchers will look at medical records of 110 women newly diagnosed with breast cancer and compare them to a …

This study tests a new mammography machine that uses a special type of X-ray to produce high-quality breast images with at least 20% less radiation than standard mammograms. About 52 women aged 40 and older who have had a mammogram before will be enrolled. The goal is to see if t…

This study tests a wearable ultrasound patch that sticks to the breast and is held in place with a sports bra. The goal is to see if it can find breast lesions as accurately as a standard handheld ultrasound. About 50 women will try the patch during a short imaging session. Resea…

This study tests a special PET/CT scan that uses a radioactive tracer to see if HER2-positive breast cancer has been completely eliminated by chemotherapy before surgery. About 42 women with early-stage breast cancer will receive the scan after their chemo. The goal is to see if …

This study looks at whether a special risk score from a mammogram can help women with dense breasts get an MRI when they need it most. About 78 women with dense breasts and normal mammograms will be invited for an MRI based on their risk score. The goal is to catch breast cancers…

This study will see if artificial intelligence can help detect breast cancer from standard chest CT scans that are already done for other reasons. Researchers will compare the AI's accuracy to mammograms and breast MRIs in 5,000 women. If successful, this could allow earlier dete…

This study tests a new PET imaging tracer called 68Ga-MY that targets a protein (5T4) found on many cancer cells but rarely on healthy cells. About 20 people with lung or breast cancer will receive the tracer and undergo PET/CT scans. The goal is to see if this new method finds t…

This study compares a new type of PET scan (FAPI) with the standard PET scan (FDG) in 15 people whose lobular breast cancer has spread. The goal is to see if the new scan finds more cancer spots, which could help doctors plan better treatment. Participants will get both scans wit…

This study compares two low-dose hormone drugs, exemestane and tamoxifen, in 140 postmenopausal women at high risk for breast cancer. The goal is to see which drug causes fewer menopausal symptoms while still helping to prevent breast cancer. Participants will take the assigned d…

This study tests whether desloratadine, a common allergy medication, can prevent or reduce nerve damage (peripheral neuropathy) caused by taxane chemotherapy in breast cancer patients. About 116 people will receive either desloratadine or a placebo during their 12-week chemo cour…

This study tests whether two types of diabetes medications (SGLT2 inhibitors and DPP-4 inhibitors) can prevent heart damage caused by the chemotherapy drug doxorubicin in women with breast cancer. About 150 Egyptian women will be randomly assigned to receive one of the drugs or s…

This study tests whether a compression sleeve with a built-in sensor can stop mild arm swelling from turning into lymphedema after breast cancer surgery. About 40 women who have early signs of swelling will wear the sleeve and be monitored. The goal is to see if the sleeve helps …

This study tests if telmisartan, a blood pressure medication, can prevent heart damage caused by the chemotherapy drug doxorubicin in breast cancer patients. Researchers will enroll 36 women who are newly diagnosed and have not had chemotherapy before. Participants will receive e…

This study tests a surgical technique to prevent arm lymphedema (swelling) in women at high risk after breast cancer surgery. The procedure uses a small flap of tissue from the side of the chest to help restore normal fluid drainage in the armpit. 100 participants will be followe…

This study tests whether rosuvastatin, a cholesterol-lowering drug, can prevent heart damage in women with breast cancer receiving anthracycline chemotherapy. 400 participants will take either rosuvastatin or a placebo daily for 12 months. The goal is to see if the drug helps mai…

This study looks at whether propranolol, a medicine used for high blood pressure and chest pain, can prevent heart injury in breast cancer patients who have these conditions and are having surgery. About 100 women will take part, and researchers will compare those who get propran…

This study tests a simple idea: wearing tight surgical gloves during chemotherapy sessions might prevent nerve damage in the hands. About 44 breast cancer patients will try it on one hand only, so doctors can compare. The goal is to see if this cheap, easy method can reduce numbn…

This study compares two ways to prevent long-term pain after breast cancer surgery: a nerve block (Pecs block) plus ketamine versus ketamine alone. About 120 women having mastectomy will be followed for 6 months to see which approach reduces chronic pain better. The goal is to fi…

This study tests a simple, low-cost method—wearing surgical gloves during chemotherapy—to prevent nerve damage in the hands caused by the drug paclitaxel. About 84 breast cancer patients will be randomly assigned to either standard care or glove compression. Researchers will trac…

This study compares a newer, less invasive breast-conserving surgery (using small incisions and an endoscope) to the standard open surgery for women with early-stage breast cancer. About 1,366 women aged 18-70 will take part to see if the new method leads to better cosmetic resul…

This study tests whether using virtual reality (VR) during chemotherapy can help breast cancer patients feel less pain and anxiety. Fifty patients who are new to chemo and already have pain or anxiety will use VR while receiving treatment. Researchers will measure their pain and …

This study looks at whether weekly acupuncture for 8 weeks can lower stress in breast cancer patients who have recently finished their main treatments like surgery, chemo, or radiation. About 112 adults with breast cancer and high stress levels will take part. The goal is to see …

This study tests an Arabic-language AI mobile app designed to support women with breast cancer during chemotherapy. The app provides medication reminders, side-effect management tips, and alerts healthcare teams about serious symptoms. Researchers will compare 130 participants us…

This study compares two non-drug methods—a small plastic device called ShotBlocker and a gentle skin-tapping technique called Helfer—to see if they can reduce pain and fear during hormone injections in breast cancer patients. About 99 women will be randomly assigned to one of the…

This study tests a decision aid (BCT Aid) for 160 women newly diagnosed with breast cancer. The goal is to see if it helps them choose between breast-conserving surgery, mastectomy, or reconstruction with less confusion and regret, and improves their quality of life. Participants…

This study tests whether a 6-week home program combining exercise and a limited eating window (10 hours or less per day) is practical and helpful for breast cancer survivors who are on hormone therapy and feel fatigued. Twenty participants will track their steps, do resistance ba…

This study will test SerenApp, a mobile app designed with input from patients and doctors to help breast cancer survivors manage anxiety, sadness, stress, and fear of cancer returning. About 90 women who have finished primary treatment will use the app for several weeks. Research…

This study tests whether a remote stress management program (R-CBSM) can help women aged 50 and older who have finished breast cancer treatment feel less distressed and potentially slow aging caused by cancer and stress. Participants will join group video calls to learn relaxatio…

This study aims to develop and test a questionnaire that helps decide which breast cancer patients truly need to come to the hospital for a check-up during their treatment. The goal is to reduce unnecessary visits, saving patients time and stress, while still catching any importa…

This study compares two surgical methods—conventional and endoscopic—for nipple-sparing mastectomy with breast reconstruction in 170 women with early-stage breast cancer. The goal is to see which approach leads to better recovery of breast skin sensation after surgery. Researcher…

This study tests a six-month online program for women recently diagnosed with breast cancer. The program offers daily guidance on exercise, stress relief, and healthy habits through videos and group chats. Researchers want to see if it reduces psychological distress and improves …

This study compares two types of nipple-sparing mastectomy (breast removal that keeps the nipple) in women with breast cancer or high genetic risk. One group gets robotic single-port surgery through a small side incision; the other gets standard open surgery. Researchers will tra…

This study looks at whether removing drainage tubes sooner after a newer type of nipple-sparing mastectomy and immediate breast reconstruction can help patients heal better and feel more satisfied. About 379 women aged 18-70 with breast cancer or those having preventive mastectom…

This study tests whether a supervised exercise program, started before chemotherapy and continued during treatment, helps adults aged 35-65 with breast, lung, or colon cancer tolerate chemo better. The goal is to see if exercise allows patients to receive more than 85% of the pla…

This study tests whether doing breathing muscle exercises at home for at least two weeks before breast cancer surgery can prevent the breathing weakness that often happens after surgery. Forty newly diagnosed adults will either do these breathing exercises or guided imagery exerc…

This study will test whether a 16-week Pilates program can improve quality of life, reduce pain and fatigue, and boost emotional well-being in 50 women currently undergoing breast cancer treatment. Participants will attend two 60-minute Pilates sessions each week. The goal is to …

This study compares two types of nerve blocks to manage pain after breast cancer surgery. 70 adults aged 18-65 will receive one of two ultrasound-guided injections near the chest wall. The goal is to see which method reduces the need for strong painkillers and improves recovery. …

This study looks at whether a supervised, moderate-intensity interval walking program can reduce inflammation, improve physical fitness, and enhance quality of life in women with breast cancer who are undergoing radiotherapy. Forty women aged 20-65 with early-stage breast cancer …

This study looks at whether hyperbaric oxygen therapy can reduce nerve pain and numbness caused by a common chemotherapy drug (nab-paclitaxel) in breast cancer patients. About 160 women who have finished chemo and developed nerve symptoms will receive either oxygen therapy or sta…

This study will test a new support program for women aged 18-59 with breast cancer who are raising children under 18. The program includes counseling and parenting guidance to help reduce anxiety about parenting. 20 participants will be enrolled to see if the program is helpful a…

This study looks at whether giving esketamine during breast cancer surgery can help reduce severe depression and anxiety in patients. About 242 women with severe depression will be randomly assigned to receive esketamine or a placebo during their operation. Researchers will measu…

This study tests whether adding logotherapy—a type of counseling that helps people find meaning in their experiences—to standard psychological support can reduce anxiety and depression in women newly diagnosed with primary breast cancer. About 66 women will be randomly assigned t…

This study tests whether taking creatine daily can prevent or reduce the memory and concentration problems (often called 'chemo brain') that many people experience during chemotherapy. About 227 adults with early-stage breast cancer will receive either creatine or a placebo, star…

This study looks at whether two types of breathing exercises—pranayama and pursed-lip breathing—can help reduce pain, anxiety, and improve vital signs in people recovering from breast surgery. About 126 adults having a mastectomy will be randomly placed into one of three groups: …

This study tests whether Qibei Jiedu Formula, a traditional Chinese medicine, can prevent or reduce skin irritation caused by radiation therapy in breast cancer patients. Sixty participants will receive either the herbal formula or a placebo alongside standard care. The goal is t…

This study tests whether watching a short 5-minute mindfulness breathing video each day can improve quality of life and mental well-being in people with breast cancer. About 50 participants who have finished chemotherapy will either practice this breathing exercise for 6 weeks or…

This study compares two types of nerve blocks to see which provides better pain relief after breast cancer surgery that includes removing lymph nodes. Sixty women aged 18-65 will be randomly assigned to receive one of the two blocks. The goal is to reduce pain and the need for st…

This study tests whether acupuncture can safely reduce anxiety and depression in women with breast cancer. Researchers will enroll 360 women who have finished active cancer treatment and still have mild to moderate mood symptoms. The goal is to see if this gentle, needle-based th…

This study tests if starting a personalized exercise program early can prevent or reduce the joint pain that many breast cancer patients get from hormone therapy (aromatase inhibitors). About 182 postmenopausal women with hormone-sensitive breast cancer will be randomly assigned …

This study tests if a mild electrical stimulation applied to the ear (called taVNS) can reduce joint and muscle pain caused by aromatase inhibitors, a common hormone therapy for breast cancer. About 216 women with hormone receptor-positive breast cancer will receive either active…

This study looks at whether giving esketamine continuously during breast cancer surgery can help reduce anxiety and depression in patients who already have mild-to-severe depressive symptoms. About 142 women will take part, and their mood and sleep quality will be tracked before …

This study tests whether a breath-based group program (Breath-Body-Mind) can help young breast cancer survivors (ages 18-50) feel less distressed. Thirty participants will be randomly assigned to either the breathing program or a standard education group. The goal is to see if th…

This study tests whether a personalized exercise program, tracked by a smartwatch, can help reduce fatigue in people who have finished chemotherapy for certain cancers. About 98 adults will be randomly assigned to either the exercise program or standard follow-up. The main goals …

This study tests whether a traditional Chinese medicine hand and foot bath can reduce nerve pain and numbness caused by taxane chemotherapy in breast cancer patients. About 78 participants will either receive the herbal bath or a standard vitamin B12-like medication. The goal is …

This study tests a bilingual online peer-support program for Korean-speaking breast cancer survivors and patients. Survivors act as mentors to current patients over 12 weeks. The goal is to see if the program is easy to use and improves quality of life, mood, and social support.

This study tests whether a brief psychological therapy called Acceptance and Commitment Therapy (ACT) can improve how well chemotherapy works in women with locally advanced breast cancer. About 54 participants will either receive standard chemotherapy alone or with added ACT sess…

This study compares three techniques—ultrasound-guided marker, magnetic seed, and wire localization—to help surgeons remove non-palpable breast tumors more accurately. About 1,300 women with early-stage breast cancer will be randomly assigned to one method. The goal is to see whi…

This study tests a short, telehealth-based pain coping skills training for women aged 55 and older with breast cancer who have ongoing pain. Participants will learn pain management techniques through one main session and five short follow-up calls. The goal is to reduce pain seve…

This early study tests the safety of using short electric pulses to destroy soft tissue tumors near the skin in people with metastatic breast cancer. About 20 adults will receive the treatment under image guidance. The main goal is to see if the procedure is safe and to measure a…

This study is testing a new web and mobile app called SHIELD, designed to help women with hormone-receptor-positive breast cancer who are on long-term endocrine therapy. The goal is to see if the app is easy to use and helpful for managing treatment. About 30 women aged 18-49 wil…

This study tests whether doing physiotherapy and mechanical stimulation before breast reconstruction surgery can reduce shoulder pain and improve movement afterward. About 72 women scheduled for a latissimus dorsi flap reconstruction will take part. Half will receive the pre-surg…

This study tests whether using nerve monitoring and a gentle electric tool during armpit lymph node removal can help surgeons find and protect small nerves that often cause long-term pain after breast cancer surgery. Six adults with breast cancer will take part. The goal is to se…

This study tests a new way to do nipple-sparing mastectomy using a tiny camera and small cuts, aiming to reduce pain and scarring. Ten women with early breast cancer or high genetic risk will try it. Doctors will check if the procedure can be done without switching to standard op…

This study tests whether a special nerve block (SPSIP block) can reduce pain and the need for strong painkillers after mastectomy and lymph node removal. About 50 women having breast cancer surgery will receive either the nerve block or a placebo. The goal is to improve recovery …

This study looks at whether breast cancer patients can safely stop taking premedication (drugs to prevent allergic reactions) after two well-tolerated doses of weekly paclitaxel chemotherapy. The goal is to see if stopping these extra drugs improves quality of life, since they ca…

This study tests a non-invasive device that stimulates a nerve in the ear to reduce joint pain and stiffness caused by aromatase inhibitors, a common breast cancer treatment. About 60 women with hormone-positive breast cancer who experience joint pain will receive either the acti…

This study tests a therapy called Meaning-Centered Psychotherapy for Latinos (MCP-L) to see if it helps reduce anxiety and depression and improve quality of life in 300 Mexican patients with advanced breast, prostate, colorectal, or thyroid cancer. Participants will be randomly a…

This study tests whether giving atropine before chemotherapy can prevent severe diarrhea in people with advanced breast cancer. About 30 participants will receive atropine alongside the drug sacituzumab govitecan. The goal is to make treatment more tolerable by reducing a common …

This study tests whether hyaluronic acid injections can improve facial appearance and quality of life in women who have completed breast cancer treatment. Many younger women experience premature skin aging due to chemotherapy or hormone therapy, which can affect self-esteem. The …

This study tests whether a continuous nerve block (erector spinae plane block) with the numbing medicine ropivacaine can reduce pain after mastectomy in 40 women with breast cancer. Participants will be randomly assigned to receive the block or standard pain care. The study will …

This study tests a drug called romiplostim N01 in 68 breast cancer patients whose platelet counts dropped too low due to chemotherapy. The goal is to see if a weekly shot can safely bring platelet levels back up within two weeks, allowing patients to continue their cancer treatme…

This study tests if using a machine to inject breast cancer medication at a steady speed causes less pain than a nurse injecting by hand. Forty women with HER2-positive breast cancer will receive both methods and rate their pain. The goal is to find a more comfortable way to give…

This study tests whether giving esketamine continuously during breast cancer surgery can reduce feelings of anxiety and depression after the operation. About 218 adults having breast cancer removal will be randomly assigned to receive esketamine or a placebo during anesthesia. Re…

This study looks at how the bacteria in your gut change when you take Verzenio (abemaciclib) for breast cancer, and whether those changes are linked to stomach issues like diarrhea. About 12 adults with hormone receptor-positive, HER2-negative breast cancer will provide stool sam…

This study looks at over 1,000 people with HER2-positive breast cancer to find different genetic types of the disease. Participants will receive standard chemotherapy plus trastuzumab and pertuzumab before surgery. The goal is to see which genetic types respond best, helping doct…

This study tests whether using more sensitive imaging methods based on a person's individual risk can detect breast cancer recurrences earlier than standard mammograms. It involves 2,300 women who had breast-conserving surgery and are at higher risk of recurrence. The goal is to …

This study is for people with early-stage breast cancer who have surgery to remove the tumor but do not have any armpit (axillary) lymph node surgery. The goal is to track their health over time to see if skipping this extra surgery leads to cancer coming back in the armpit or af…

This study aims to understand why some breast cancers resist chemotherapy. Researchers will grow miniature 3D tumor models (organoids) from patient tissue samples and test how they respond to drugs. By linking lab results to actual patient outcomes, they hope to find ways to pred…

This study looks at breast cancer in women 45 and younger, focusing on how pregnancy and breastfeeding might influence the disease. Researchers will collect information on patients' reproductive history and analyze tumor samples. The goal is to better understand why breast cancer…

This study explores why some breast cancer patients get diarrhea from the drug pyrotinib while others don't. Researchers will compare the gut bacteria of 60 patients who develop diarrhea with those who don't, using stool samples. The goal is to find protective bacteria that could…

This study looks at bacteria living inside breast tumors and compares them to bacteria in nearby healthy tissue, urine, and stool. Researchers want to see if these bacteria differ across breast cancer types and if they relate to how the cancer behaves. The study involves 240 wome…

This study will follow 100 newly diagnosed breast cancer patients in Egypt to see how chemotherapy affects their thinking, memory, and emotions. Researchers will use questionnaires and tests before treatment and one year later. The goal is to better understand these side effects …

This study looks at whether a blood test can find tiny bits of cancer DNA left after surgery in people with breast, lung, prostate, ovarian, or stomach cancer. About 840 adults who had surgery to remove their cancer will give blood samples over 9 months. The goal is to see how of…

This study looks back at medical records of 200 breast cancer patients to see if having COVID-19 increases the risk or severity of lung inflammation caused by radiation therapy. Researchers will compare patients who had COVID-19 with those who did not. The goal is to better under…

This study tests whether doing broad genetic testing early, instead of later, helps more people with advanced pancreatic, liver, or triple-negative breast cancer get treatments that match their tumor's genetic makeup. About 360 adults with advanced disease will be randomly assign…

This study checks if a newer, cheaper DNA sequencing machine (MGI) works as well as the current standard (Illumina) for finding gene changes linked to hereditary cancers like breast, ovarian, and Lynch syndrome. Researchers will compare results from both machines using the same D…

This study will follow 81 people with early-stage, hormone-positive breast cancer who are at high risk of the cancer coming back. Researchers want to see how often patients stop taking their prescribed CDK4/6 inhibitor pills (abemaciclib or ribociclib) before the full treatment c…

This study tests a special scanner that lets doctors check if all cancer has been removed during breast cancer surgery, right in the operating room. About 20 women with breast cancer will have their surgical samples scanned without damaging the tissue. The goal is to see if this …

This study aims to confirm whether everyday chemicals called endocrine disruptors are linked to breast cancer. Researchers will measure these chemicals in urine, hair, and breast fat tissue from 42 women scheduled for breast lesion removal. They will also look for biological mark…

This study aims to find the best score on a simple, self-administered questionnaire to tell if a breast cancer survivor has mild nerve damage from chemotherapy. Researchers will enroll 28 women who had taxane-based chemo and radiation. The goal is to improve detection of this com…

This early-phase study tests a new PET camera designed specifically for breast imaging, with very high resolution. The main goal is to see how well the camera works in a real clinic and whether it can produce clear images. About 20 women with biopsy-confirmed breast cancer will t…

This study aims to find the best score on a simple, self-administered questionnaire that can tell if a breast cancer survivor has moderate to severe nerve damage from chemotherapy or none at all. The trial will include 26 women who have had taxane-based chemotherapy and radiation…

This study looks at whether a blue dye alone can safely find cancer in lymph nodes after chemotherapy in women with breast cancer that had spread to the lymph nodes. About 240 women will get the dye injection during surgery, followed by standard lymph node removal. The goal is to…

This study aims to see if a simple finger-prick blood sample can accurately measure levels of certain breast cancer drugs (CDK4/6 inhibitors) compared to standard blood draws from a vein. About 90 adult breast cancer patients currently taking these drugs will provide both types o…

This study will follow 2,200 young women (age 40 or younger) who had breast cancer and carry certain gene changes (like TP53 or PALB2) but not BRCA1/2. Researchers want to see if getting pregnant after cancer treatment affects the chance of the cancer coming back. The goal is to …

This study looks at how well proton radiation targets breast cancer after surgery. Researchers will use PET/CT scans to measure beam accuracy and see if errors lead to side effects like lung inflammation or rib fractures. About 30 women will join to help improve future treatment …

This study collects ultrasound images from 100 women who have had a breast biopsy marker placed. The goal is to train an AI software to automatically detect these markers during routine scans. Participants receive standard care, and the AI results are not used for diagnosis or tr…

This study aims to learn more about breast cancer by measuring a specific genetic marker (PCGEM1) in blood and tissue samples. Researchers will compare levels in people with breast cancer to those without. The goal is to better understand how the disease develops and find new tar…

This study looks at two ways to rebuild a breast after cancer surgery: one where the implant is placed right away, and another where a temporary expander is used first. Researchers will compare how often the implant is lost within 3 months, as well as other complications. The goa…

This study looks at why some older breast cancer survivors have more trouble with memory and thinking after chemotherapy. Researchers will study 152 women aged 60-85 to see how diet, exercise, stress, sleep, and health markers like blood sugar and cholesterol affect brain functio…

This study tests whether special PET/MRI scans using specific tracers can predict how well breast cancer treatments work. About 300 women with breast cancer will get these scans before and after two treatment cycles. The goal is to find which tracers best show if a treatment is e…

This study looks at whether women identified as having a higher risk of breast cancer will attend extra imaging exams. About 3,000 women in Norway are invited: those with very dense breast tissue get an additional 3D mammogram within 6 months, and those with a false-positive resu…

This study will observe about 109 women in Gulf countries who have a specific type of advanced breast cancer (HR-positive, HER2-low or ultra-low) and are taking the drug trastuzumab deruxtecan (T-DXd) after hormone therapy stopped working. Researchers will track how long the canc…

This study aims to create a tool that uses changes in a hormone called AMH to predict whether perimenopausal women with breast cancer will enter menopause after treatment. About 300 women aged 45-55 will have blood samples taken at seven different times. The goal is to help docto…

This study looks at how the amount of abemaciclib in the blood is linked to severe diarrhea in people with hormone receptor-positive breast cancer. About 235 women with early-stage, high-risk breast cancer will have their blood levels measured during treatment. The goal is to cre…

This study tests whether a culturally tailored program can help Black women get recommended mammograms. About 176 Black women age 40 and older who are scheduled for a screening mammogram will take part. The goal is to see if the program lowers no-show rates and helps reduce healt…

This study will test a new artificial intelligence (AI) tool that helps breast cancer patients learn about their condition and treatment. About 35 adults with breast cancer will use the AI to ask questions and get answers. Doctors will check if the information is safe, accurate, …

This study looks at whether a color Doppler ultrasound feature called 'twinkling artifact' can make breast tissue marker clips more visible. These clips are placed to mark tumors or lymph nodes for surgery. The study will review past images from about 86 women with breast cancer …

This study is testing whether a well-known community weight loss program called TOPS can be adapted to better help breast cancer survivors lose weight. Researchers will first get feedback from survivors in focus groups, then use that feedback to run tailored TOPS classes. The goa…

This study looks at whether training doctors in shared decision-making and giving patients educational materials can improve conversations about treatment for HER2-negative metastatic breast cancer. About 120 patients starting their first treatment will join, and their experience…

This study is for young adults (ages 21-45) who had certain cancers as teens or young adults. Researchers are adapting a program that helps patients manage follow-up care and feel more in control of their health. The goal is to see if the program is helpful and practical for use …

This study looks at whether analyzing tumor cells found in the blood can help predict how well certain cancer drugs (PARP inhibitors and chemotherapy) will work. Researchers will collect blood samples from 300 adults with advanced breast, prostate, pancreatic, or ovarian cancer. …

This study surveys 240 breast cancer patients (stages I–III) who have had chemotherapy or hormone therapy. The goal is to learn which herbs and supplements people use, how ethnicity influences those choices, and how they might interact with standard treatments. No new treatment i…

This study looks at how the bacteria in your gut (microbiome) might influence diarrhea and other stomach issues caused by the breast cancer drug abemaciclib. It involves 20 adults with HR+/HER2- breast cancer. First, researchers will collect stool samples to study gut bacteria. T…

This study looks at how often taste changes happen in women with early-stage breast cancer who are getting chemotherapy. Researchers will use taste tests to measure changes in sweet, sour, salty, and bitter perception. They will also check how these changes affect eating habits, …

This study looks at whether tiny particles called exosomes, released by breast cancer cells, can help predict how well a tumor will respond to chemotherapy given before surgery. Researchers will collect blood and tumor tissue from 60 women with breast cancer and analyze their mic…

This study will give a radioactive version of a breast cancer drug to 6 healthy postmenopausal women. The goal is to see how the drug moves through the body, how it breaks down, and how it leaves the body. This helps researchers understand the drug better before testing it in pat…

This study will test whether a training program based on the Health Belief Model can increase how often women perform breast self-exams and improve their knowledge and awareness of breast cancer while reducing fear. About 76 women aged 20 to 69 who have not had breast cancer will…

This study looks at whether a hormone called GDF-15, measured in the blood, can predict which breast cancer patients will experience severe nausea and vomiting from the drug T-DXd. Researchers will track 150 patients starting T-DXd treatment and compare their GDF-15 levels with s…

This study looks at how a personalized strength training program affects people with different cancers (lung, colon, breast, lymphoma, and leukemia). 150 adults will either do supervised strength training plus home exercises, or just home exercises, for 12 weeks. Researchers will…

This study looks at how well the DPD enzyme works in people with cancer and/or kidney failure. The DPD enzyme breaks down common chemotherapy drugs, and low activity can cause severe side effects. Doctors currently use a blood test to check DPD function, but kidney problems may m…

This study tests a virtual reality (VR) program called SurviVRSE that teaches breast cancer survivors about heart health. About 30 women currently receiving certain cancer treatments will try the VR program. Researchers will check if the program is easy to use, acceptable, and if…

This study looks at how cancer and its treatments change the way patients experience food, including taste, appetite, and enjoyment of eating. Researchers will survey 180 adults with breast, head and neck, gynecologic, gastrointestinal, or lung cancer to understand which factors …