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New program aims to catch late effects in childhood cancer survivors

NCT ID NCT05832138

Disease control Sponsor: The Hospital for Sick Children Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This trial tests a program called ONLOOP that reminds adult survivors of childhood cancer to get important screening tests. These tests can find late effects like heart disease or second cancers early. About 900 survivors in Ontario will be randomly assigned to get the reminders or usual care. The goal is to see if the program helps more people complete their recommended screenings.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 900 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Oct 2025

An estimate. Start dates often move.

Expected to finish

Dec 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Survivors of childhood cancer who are currently aged 18 and older * Diagnosed with cancer before age 18 between 1986-2017 * At least 5 years from most recent childhood cancer event (latest of primary diagnosis, relapse, or second cancer before age 18) * Treated at one of Ontario's five specialized childhood cancer programs * Received radiation and/or anthracycline treatment that increased the survivor's risk of cardiomyopathy, breast cancer, and/or colorectal cancer * Overdue for guideline-recommended surveillance by ≥6 months (mammogram and breast MRI, colonoscopy, and/or echocardiogram) Exclusion Criteria: * Was not diagnosed or was not fully treated at one of Ontario's five pediatric cancer centres * Developed a second cancer or relapse of their primary cancer after age 18 * Not currently living in Ontario or address deemed ineligible by Ontario Health * Opted out of a similar Ontario Health program (eg, the Ontario Breast Screening Program) * Previously opted out of receiving invitations for Ontario Health research studies or similar communications

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Conditions

The condition(s) this trial relates to.

breast cancer breast neoplasm cancer childhood malignant neoplasm colorectal cancer colorectal neoplasm heart disorder neoplasm Neoplasms, Second Primary secondary malignant neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Breast cancer Cancer Colorectal cancer Heart diseases Secondary cancer Survivorship

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  2. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

More trials for these conditions

Other studies related to the condition(s) this trial covers.