The Hospital For Sick Children

This study tests whether deep brain stimulation (DBS) can reduce severe, repeated self-injury in children with autism. About 25 children aged 5-17 will receive DBS to a brain area linked to reward and behavior. The goal is to control these dangerous behaviors and improve quality …

This study tests whether metformin, a common diabetes drug, can safely help repair nerve damage in children and young adults (ages 10-25) with multiple sclerosis. Participants take metformin daily for 3 to 9 months, starting at different times. The main goals are to see if the dr…

This early-stage study tests whether a supplement called L-Citrulline is safe for preterm infants who have lung disease (BPD) or a serious gut condition (NEC). The goal is to see if raising low levels of this natural substance can reduce harmful inflammation. About 36 infants wil…

This study looks at whether a Mediterranean diet can improve arthritis in children by changing the bacteria in their guts. Fifty-four kids with juvenile idiopathic arthritis will follow the diet for 8 weeks, with an option to continue for 4 more weeks. Researchers will collect st…

This study looks at whether special MRI scans and breathing tests can help doctors diagnose bronchiolitis obliterans syndrome (BOS) earlier in children who have had a stem cell transplant. About 15 children aged 6 to 17 will do breathing tests and an MRI while holding their breat…

This study tests whether adding olanzapine, a safe and inexpensive drug already used in children for other conditions, to standard anti-nausea medicines can better control vomiting in 200 children receiving strong chemotherapy. The goal is to reduce one of the most distressing si…

This study tests whether a special nerve block (PECS) given before surgery can lower the amount of strong pain medicine (opioids) children need after getting a heart device like a pacemaker. About 48 kids aged 3-18 will be randomly assigned to get either the nerve block or standa…

This study looks at whether children with medical complexity (ages 5-17) can safely start using a nighttime breathing machine at home instead of in a hospital sleep lab. Half the children will start at home, half in the lab, and researchers will compare how well each approach wor…

This study tests an online program that helps parents of children with congenital heart disease (ages 3-9) improve their parenting skills and manage child behavior. About 382 families from SickKids in Ontario will take part. The program is designed to be convenient and supportive…

This study tests whether a computer model (machine learning) can help prevent vomiting in children being treated for cancer. About 1,332 children admitted to the hospital will have their risk of vomiting in the next 96 hours predicted daily. Pharmacists will then alert the medica…

This study looks at how much of four essential amino acids (isoleucine, leucine, valine, and tryptophan) stable newborn babies need when they get all their nutrition through an IV (total parenteral nutrition, or TPN). Researchers will enroll about 80 babies across two hospitals i…

This study tests whether a machine-learning model can predict serious heart events in children admitted to the hospital. The goal is to see if the model helps doctors involve the palliative care team earlier. Researchers will compare what happens before and after the model is use…

This study tests two new types of lung MRI (using special gases) to see if they can better detect lung problems in people with cystic fibrosis and asthma compared to healthy volunteers. About 30 people aged 8 and older will have these scans to check how well the images show lung …

This study uses a special camera (adaptive optics) to take detailed pictures of the back of the eye in people with inherited retinal diseases. Researchers want to understand how the disease affects light-sensing cells and blood vessels. The goal is to find better ways to track di…

This study tests whether a machine learning model can predict which children will need a targeted medication in the next three months. The goal is to help doctors order pharmacogenetic testing beforehand, so they can choose the right drug or dose based on the child's genes. About…