The Hospital For Sick Children

This study tests whether a structured care plan called Neonatal Enhanced Recovery After Surgery (nERAS) can help newborns recover better after major non-cardiac surgery. Surgery is very stressful on a baby's body, and the plan bundles evidence-based recommendations to standardize…

This study tests whether a high-flow nasal cannula (HFNC) — a soft tube that delivers warm, humidified air through the nose — works as well as the standard CPAP mask for children with moderate-to-severe obstructive sleep apnea. About 258 children aged 2 to 18 will use one of the …

This study looks at whether a non-invasive technique called focused ultrasound can safely treat brain lesions that cause seizures in children with drug-resistant epilepsy. About 20 children aged 4-17 will be followed to see if the treatment reduces seizure frequency and severity,…

This trial tests a program called ONLOOP that reminds adult survivors of childhood cancer to get important screening tests. These tests can find late effects like heart disease or second cancers early. About 900 survivors in Ontario will be randomly assigned to get the reminders …

This trial tests whether non-geneticist doctors in Ontario can order genome-wide sequencing for patients with suspected rare genetic diseases. The goal is to see if this approach speeds up diagnoses and reduces the burden on genetic specialists. Researchers will track how often t…

This study tests an AI tool that analyzes ultrasound images to help doctors decide if a baby with hydronephrosis (kidney swelling) needs surgery. About 322 infants up to 24 months old will take part. Doctors first make a care plan without the AI, then see the AI's prediction and …

This study tests whether a mechanical 3D ultrasound device can detect joint damage in people with hemophilia as accurately as a full ultrasound or MRI. Eleven participants will have their ankles scanned with the new device. If it works well, it could offer a faster, less expensiv…

This study explores whether a self-guided web program called 'Better Nights, Better Days for Youth' can improve sleep and reduce pain in teenagers with rheumatic diseases like arthritis and lupus. Teens aged 12-18 with sleep problems will track their sleep and pain daily, then us…

This study tests whether a specialized cognitive behavioral therapy called TEACH can improve mental health and well-being in adolescents with childhood-onset lupus. Researchers will measure changes in brain function, blood markers of inflammation, and symptoms like depression, fa…

This pilot study tests a new model of mental health support for siblings aged 10-17 of children with medical complexity. The model uses screening and assessments by social workers, who can provide talk therapy or refer to a child psychiatrist for diagnosis and treatment. The goal…

This pilot study tests whether giving dexamethasone (a steroid) to children hospitalized with orbital cellulitis (a serious eye infection) is worth studying further. Thirty children will receive either dexamethasone or a placebo by IV. The main goal is to see if a larger trial is…

This pilot study tests a smartphone app called PainCaRe, designed to help parents of young children (ages 2-11) with cancer manage their child's pain at home. The app asks parents to report their child's pain daily and gives personalized, evidence-based pain relief tips. The stud…

This trial tests two ventilator modes in children who need a machine to breathe. The goal is to see which mode reduces the effort of breathing and improves comfort. Researchers will measure how hard children work to breathe and how often breathing is out of sync with the ventilat…

This study looks at whether the placement of the anesthesia machine in an operating room affects how well anesthesiologists handle crisis situations. About 60 doctors will manage a simulated emergency using a manikin, with the machine placed in either an easy or awkward position.…

This study explores whether MRI can produce clear images of the lungs and airways in people with cystic fibrosis (CF) and healthy volunteers. Researchers will use computer assistance to measure airway size and shape, and repeat the MRI two years later to see if changes occur. A s…

This study looks at whether you need to eat complementary plant proteins—like rice and beans—at the same meal to get all the amino acids your body needs. Researchers will give 40 healthy young and older adults five different diets over nine days each and measure how their bodies …