The Hospital For Sick Children

This early-phase study tests whether an oral supplement called L-Citrulline is safe for preterm babies born at or before 30 weeks who have lung problems (BPD) or a serious gut condition (NEC). The goal is to see if raising low levels of a natural substance in the blood can reduce…

This trial tests whether deep brain stimulation (DBS) of the nucleus accumbens can reduce severe, repetitive self-injurious behaviors in 25 children aged 5-17 with autism. Half will get active stimulation, half will have the device off, and parents will report behavior changes. T…

This study tests whether metformin, a widely used diabetes drug, is safe and feasible for children and young adults (ages 10-25) with multiple sclerosis. Participants take metformin daily for 3 to 9 months, with the start time randomly assigned. The main goal is to see if the dru…

This study is testing whether a special MRI using xenon gas can better detect bronchiolitis obliterans syndrome (BOS), a serious lung condition, in children who have had a stem-cell transplant. Fifteen children aged 6 to 17 will undergo breathing tests and the xenon MRI. The goal…

Researchers are testing whether training community health workers and clinic staff to give advice on nutrition, hygiene, and heat adaptation can improve the health of mothers and young children in rural Sindh, Pakistan. The trial enrolls households with pregnant or breastfeeding …

This trial tests whether the design of a ureteral stent—a small tube that drains urine from the kidney to the bladder—affects comfort in children aged 8 to 18 undergoing staged kidney stone treatment. Each participant will receive both a standard Cook stent and a Polaris Ultra st…

This study looks at whether a Mediterranean-style diet can improve arthritis symptoms in children by changing the bacteria in their gut. Fifty-four children aged 8-18 with juvenile idiopathic arthritis will follow the diet for 8 weeks, with an option to continue for 4 more weeks.…

This study is testing a smartphone app called MedlyPeds that lets children with heart disease send their weight, blood pressure, and heart rate to their doctors from home. The app also asks about symptoms and sends personalized tips. The goal is to see if the app is easy to use a…

This study looks at whether children with medical complexity (ages 5-17) can safely start using a nighttime breathing machine at home instead of in a hospital sleep lab. The machine helps them breathe better at night, improving quality of life. Researchers will compare home start…

This study tests an online program called I-InTERACT-North that helps parents of children aged 3-9 with congenital heart disease improve their parenting skills and manage child behavior. About 382 families from SickKids in Ontario will take part. The goal is to see if the program…

This study tests whether a pectoral nerve block (PECS) given before surgery can lower pain and the need for morphine after a heart device implant in children aged 3 to 18. Half the children will get the nerve block plus standard wound numbing, while the other half get only wound …

This study follows 120 children with intestinal failure who have stopped receiving nutrition through an IV (parenteral nutrition) for at least a year. Researchers want to see if these children grow up healthy by checking for poor growth, vitamin shortages, weak bones, unusual bod…

This study uses a special camera (adaptive optics) to take detailed pictures of the back of the eye in people with inherited retinal diseases. Researchers want to see how individual cells change over time and after treatments. About 200 participants aged 5 to 70 will be observed,…

This study looks at how much of four essential amino acids (isoleucine, leucine, valine, and tryptophan) premature babies need when they get nutrition through an IV. Researchers will test about 80 stable newborns in Brazil to see if current commercial formulas provide too much of…

This study is testing two new types of lung MRI that use special gases (xenon and perfluoropropane) to create detailed images of lung function. Researchers will compare these scans in 30 people with cystic fibrosis, asthma, and healthy volunteers to see if they can spot lung prob…