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New combo aims to stop pain before it starts in breast cancer surgery

NCT ID NCT07197684

Prevention Sponsor: Aga Khan University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether adding an ultrasound-guided nerve block (Pecs block) to a ketamine infusion can prevent chronic pain after breast cancer surgery. 120 women scheduled for mastectomy will be randomly assigned to receive either ketamine alone or ketamine plus the nerve block. They will be followed for 6 months to see how many develop long-term pain.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Ketamine
What this could lead to
If successful, this could offer a simple way to prevent long-term pain after breast cancer surgery, improving quality of life for many women.
What could go wrong
This is a small, early-stage trial (120 participants) comparing two approaches, so results may not apply to everyone. The nerve block adds a procedure with its own small risks.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 120 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Mar 2026

An estimate. Start dates often move.

Expected to finish

May 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 75 years

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adult female patients with breast cancer aged between 18-75 years * ASA (American Society of Anesthesia) physical status I, II, and III * Patients scheduled for elective breast cancer surgery (Mastectomy with or without axillary clearance) Exclusion Criteria: * Refusal to participate or withdrawal of informed consent * Surgical procedures involving breast reconstruction with flaps or implants * Patient scheduled for bilateral mastectomy * Reoperation on the same side due to cancer recurrence * Known allergy or contraindication to study drugs * History of severe psychiatric illness (e.g., major depression, bipolar disorder, schizophrenia) * Chronic opioid use, substance abuse, or opioid addiction * Pre-existing chronic pain or neuropathic pain disorders * Coagulopathy, anticoagulation therapy, or localized infection at the site of block * Uncontrolled hypertension and ischemic heart disease

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Conditions

The condition(s) this trial relates to.

breast cancer breast neoplasm Chronic Pain chronic pain syndrome Pain, Postoperative

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Breast cancer Pain, chronic Post-surgical pain

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  2. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

More trials for these conditions

Other studies related to the condition(s) this trial covers.