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Can vitamin d tweak breast cancer genes? weight may matter

NCT ID NCT01472445

Disease control Sponsor: Melinda Telli Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early This study
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looked at whether taking vitamin D could change certain genes in breast cancer tumors, and if a woman's weight affected those changes. Researchers gave 41 women with breast cancer either a low or high dose of vitamin D before surgery. The goal was to see if vitamin D could reverse negative effects linked to obesity, but the study was stopped early, so the findings are not conclusive.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Vitamin D (cholecalciferol)
What this could lead to
If successful, this could point toward a way to use vitamin D to influence breast cancer growth, especially in women with different body weights.
What could go wrong
This was a small, early-phase study that was terminated early, so results are limited. Vitamin D is not a proven breast cancer treatment, and high doses may have side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

41 people

The number who actually took part.

Start date

Nov 2011

Finished

Oct 2015

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Women who have undergone a core needle biopsy demonstrating an operable breast cancer whom have not yet had any further therapy. * No prior therapy for breast cancer. * Age 18 years or older. * Any menopausal status * Planned surgical resection of breast cancer or repeat core biopsy tissue sampling prior to initiation of neoadjuvant systemic chemotherapy. * Availability of tissue blocks from initial core needle biopsy. * Signed informed consent. * Willing to discontinue use of all supplements containing Vitamin D for the duration of the study, and take only the Vitamin D provided by the study. Exclusion Criteria: * Presence of any Metastatic lesion. * History of parathyroid disease, hypercalcemia, or kidney stones. * History of Selective estrogen receptor modulator (SERM) or aromatase inhibitor therapy. * Receiving metformin. * History of renal failure requiring dialysis or kidney transplantation. * Women who are known to be pregnant or who are nursing. (As vitamin D does not have toxicity to the fetus, a negative pregnancy test is not a requirement to participate in the study.) * Patients planned for surgical therapy of their breast cancer or initiation of systemic chemotherapy, that would not allow for at least 7 days of vitamin D intervention * Any condition potentially interfering with subjects ability to comply with taking study medication. * Any medical condition that would potentially interfere with vitamin D absorption. * Current participation in another research study that would increase risk to subject, in the opinion of the investigators. * Patients currently taking more than 2000 IU of Vitamin D.

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Conditions

The condition(s) this trial relates to.

breast cancer breast neoplasm Obesity

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Breast cancer

Contacts and locations

Locations

  • Stanford University Cancer Institute

    Stanford, California, 94305, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.