New hope for advanced breast cancer: experimental combo vs standard care
NCT ID NCT05909397
First seen Feb 12, 2026 · Last updated May 24, 2026 · Updated 14 times
Summary
This study tests a new medicine called vepdegestrant combined with palbociclib against the standard treatment (letrozole plus palbociclib) for people with advanced ER+/HER2- breast cancer that cannot be cured by surgery. Participants must not have received any prior cancer treatment for their advanced disease. The goal is to see if the new combination works better at slowing cancer growth.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Aichi Cancer Center Hospital
Nagoya, Aichi-ken, 464-8681, Japan
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BRCR Global
Plantation, Florida, 33322, United States
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BRCR Medical Center Inc
Plantation, Florida, 33322, United States
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Barwon Health
Geelong, Victoria, 3220, Australia
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Cancer Hospital Chinese Academy of Medical Science
Beijing, Beijing Municipality, 100021, China
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Cancer Research SA
Adelaide, South Australia, 5000, Australia
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Centro Gaucho Integrado De Oncologia, Hematologia, Ensino E Pesquisa
Porto Alegre, Rio Grande do Sul, 90110-270, Brazil
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Centro de Pesquisa Clínica - Área Administrativa
Porto Alegre, Rio Grande do Sul, 90850-170, Brazil
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Complejo Hospitalario de Jaén
Jaén, JAÉN, 23007, Spain
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Debreceni Egyetem Klinikai Kozpont
Debrecen, 04032, Hungary
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Fakultna nemocnica s poliklinikou J.A. Reimana Presov
Prešov, 080 01, Slovakia
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Fondazione IRCCS San Gerardo dei Tintori
Monza, Lombardy, 20900, Italy
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Hospital Clinico San Carlos
Madrid, 28040, Spain
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Hospital Mae de Deus
Porto Alegre, Rio Grande do Sul, 90880-480, Brazil
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Hospital Santa Rita de Cassia
Vitória, Espírito Santo, 29043-260, Brazil
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Hospital Universitari Dexeus
Barcelona, Catalunya [cataluña], 08028, Spain
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Hospital Universitario Virgen de la Victoria
Málaga, Málaga, 29010, Spain
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Hospital Unviersitario Virgen Nieves
Granada, 18012, Spain
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Hubei Cancer Hospital
Wuhan, Hubei, 430079, China
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IRCCS - Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori"
Meldola, Emilia-Romagna, 47014, Italy
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Institut Català d'Oncologia (ICO) - Badalona
Badalona, Barcelona [barcelona], 08916, Spain
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Istituto Nazionale Tumori IRCCS Fondazione Pascale
Naples, Campania, 80131, Italy
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National Cancer Center Hospital
Chuo-ku, Tokyo, 104-0045, Japan
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National Cancer Center Hospital East
Kashiwa, Chiba, 277-8577, Japan
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Nemocnica na okraji mesta n o
Partizánske, 95801, Slovakia
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Sun Yat-sen University Cancer Center
Guangzhou, Guangdong, 510060, China
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The First Affiliated Hospital of Xi'an Jiaotong University
Xi'an, Shaanxi, 710061, China
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Tumor Zentrum Aarau
Aarau, Canton of Aargau, 5000, Switzerland
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Virginia Oncology Associates
Norfolk, Virginia, 23502, United States
Conditions
Explore the condition pages connected to this study.