Could targeted therapy replace chemo for certain breast cancers?
NCT ID NCT06068985
First seen Feb 14, 2026 · Last updated May 22, 2026 · Updated 15 times
Summary
This study looks at whether some women with HER2-positive early breast cancer can be treated with a combination of two targeted drugs (pertuzumab and trastuzumab) without needing chemotherapy. The researchers are selecting patients whose tumors are strongly driven by the HER2 pathway. The goal is to see if this approach can still eliminate the tumor before surgery, potentially sparing patients from chemotherapy side effects.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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A.C. Camargo Cancer Center
São Paulo, São Paulo, 01.509-001, Brazil
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Centro Paulista de Oncologia (Oncoclínicas)
São Paulo, São Paulo, 04.538-135, Brazil
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Centro de Câncer de Brasília - CETTRO (Oncoclínicas)
Brasília, Federal District, 70.710-904, Brazil
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Centro de Pesquisa Vencer & Oncoclínica
Teresina, Piauí, 60.449-200, Brazil
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Centro de Pesquisa do Hospital Pérola Byington
São Paulo, São Paulo, 01.317-000, Brazil
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Centro de Pesquisa em Oncologia do Hospital São Lucas da PUCRS - CPO
Porto Alegre, Rio Grande do Sul, 90.610-000, Brazil
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Hospital da Fundação Oswaldo Aranha - HFOA
Volta Redonda, Rio de Janeiro, 27.251-260, Brazil
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Hospital de Amor de Barretos
São Paulo, São Paulo, 14.784-400, Brazil
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Instituto Nacional de Câncer - INCA
Rio de Janeiro, Rio de Janeiro, 20.230-130, Brazil
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Instituto do Câncer do Estado de São Paulo - ICESP
São Paulo, São Paulo, 01.246-000, Brazil
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Núcleo de Oncologia da Bahia - NOB (Oncoclínicas)
Salvador, Estado de Bahia, 40.170-110, Brazil
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Oncocentro Belo Horizonte (Oncoclínicas)
Belo Horizonte, Minas Gerais, 30.360-680, Brazil
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Santa Casa de Porto Alegre
Porto Alegre, Rio Grande do Sul, 90.050-170, Brazil
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Universidade Estadual de Campinas - UNICAMP
Campinas, São Paulo, 13.083-881, Brazil
Conditions
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