HER2-POSITIVE BREAST CANCER
Clinical trials for HER2-POSITIVE BREAST CANCER explained in plain language.
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New study tests smart sequencing to beat advanced breast cancer
⭐️ CURE ⭐️ Recruiting nowThis study tests a personalized approach for people with HER2-positive breast cancer that has spread. Doctors use blood tests (ctDNA) and scans to adjust treatments over time, adding local therapies and brain-protecting steps. The goal is to see if this can lead to long-lasting r…
Matched conditions: HER2-POSITIVE BREAST CANCER
Phase: PHASE2 • Sponsor: Memorial Sloan Kettering Cancer Center • Aim: ⭐️ CURE ⭐️
Last updated May 26, 2026 02:19 UTC
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Can surgery and radiation wipe out early-spread breast cancer? new trial aims for cure.
⭐️ CURE ⭐️ Recruiting nowThis study tests whether adding surgery and targeted radiation to standard treatment can cure HER2-positive breast cancer that has spread to up to 5 spots in the body. About 178 adults with this condition will be randomly assigned to get either usual care alone or usual care plus…
Matched conditions: HER2-POSITIVE BREAST CANCER
Phase: PHASE2 • Sponsor: Memorial Sloan Kettering Cancer Center • Aim: ⭐️ CURE ⭐️
Last updated May 26, 2026 02:11 UTC
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New drug aims to cure breast cancer that has spread to just a few places
⭐️ CURE ⭐️ Recruiting nowThis study tests a drug called trastuzumab-deruxtecan (T-DXd) in people with HER2-positive breast cancer that has spread to 1-5 distant spots (oligo-metastatic). The goal is to shrink or eliminate all cancer with a year of treatment, including local therapies like surgery or radi…
Matched conditions: HER2-POSITIVE BREAST CANCER
Phase: PHASE2 • Sponsor: The Netherlands Cancer Institute • Aim: ⭐️ CURE ⭐️
Last updated May 20, 2026 11:54 UTC
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New vaccine aims to train immune system to attack breast cancer
⭐️ VACCINE ⭐️ Recruiting nowThis early-phase trial tests an investigational vaccine designed to teach the immune system to recognize and attack HER2-positive breast cancer cells. The study includes 36 adults with locally advanced HER2-positive breast cancer. The main goals are to check the vaccine's safety …
Matched conditions: HER2-POSITIVE BREAST CANCER
Phase: PHASE1 • Sponsor: Pravin T.P Kaumaya • Aim: ⭐️ VACCINE ⭐️
Last updated May 18, 2026 12:13 UTC
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New drug targets rare cancer mutation in 300-Patient trial
Disease control Recruiting nowThis study tests a new drug called PC14586 (rezatapopt) in people with advanced solid tumors that have a specific TP53 Y220C mutation. The goal is to see if the drug is safe and shrinks tumors. About 300 adults whose cancer has worsened after prior treatment will take the drug al…
Matched conditions: HER2-POSITIVE BREAST CANCER
Phase: PHASE1, PHASE2 • Sponsor: PMV Pharmaceuticals, Inc • Aim: Disease control
Last updated May 26, 2026 02:22 UTC
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Engineered immune cells take aim at Hard-to-Treat breast cancers
Disease control Recruiting nowThis study is testing a new treatment for people with advanced breast cancer that has not responded to standard therapies. The treatment uses specially designed immune cells (CAR-NK cells) that are tailored to attack specific markers on each person's tumor. The goal is to see if …
Matched conditions: HER2-POSITIVE BREAST CANCER
Phase: PHASE1, PHASE2 • Sponsor: Beijing Biotech • Aim: Disease control
Last updated May 26, 2026 02:19 UTC
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New study to see how a leading breast cancer drug performs in everyday chinese clinics
Disease control Recruiting nowThis study is observing 800 Chinese adults with advanced HER2-positive or HER2-low breast cancer who are taking trastuzumab deruxtecan (T-DXd). Researchers will track how long the drug controls the cancer and note any side effects in real-world settings. The goal is to understand…
Matched conditions: HER2-POSITIVE BREAST CANCER
Sponsor: Daiichi Sankyo • Aim: Disease control
Last updated May 26, 2026 02:17 UTC
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New study tests safer treatments for early HER2 breast cancer
Disease control Recruiting nowThis study is for people with early-stage HER2-positive breast cancer who have had surgery. It compares two treatment plans: one uses the drug T-DM1 followed by trastuzumab, and the other uses paclitaxel plus trastuzumab. The goal is to see which plan has fewer side effects and b…
Matched conditions: HER2-POSITIVE BREAST CANCER
Phase: PHASE2 • Sponsor: Dana-Farber Cancer Institute • Aim: Disease control
Last updated May 26, 2026 02:16 UTC
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New vaccine boosts breast cancer treatment before surgery
Disease control Recruiting nowThis study tests whether adding a special vaccine (dendritic cell vaccine) to standard chemotherapy and targeted therapy can improve outcomes for people with HER2-positive breast cancer. About 53 participants with early-stage breast cancer will receive the vaccine alongside stand…
Matched conditions: HER2-POSITIVE BREAST CANCER
Phase: PHASE2 • Sponsor: H. Lee Moffitt Cancer Center and Research Institute • Aim: Disease control
Last updated May 26, 2026 02:15 UTC
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New hope for HER2+ breast cancer: zanidatamab plus chemo aims for complete tumor disappearance before surgery
Disease control Recruiting nowThis study tests whether adding zanidatamab to standard chemotherapy can completely eliminate cancer in the breast and armpit before surgery in people with early-stage HER2-positive breast cancer. About 125 participants with stage II or III disease will receive the combination an…
Matched conditions: HER2-POSITIVE BREAST CANCER
Phase: PHASE2 • Sponsor: Jazz Pharmaceuticals • Aim: Disease control
Last updated May 26, 2026 02:14 UTC
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Promising drug combo targets tough breast cancer in new trial
Disease control Recruiting nowThis study tests two drugs, trastuzumab deruxtecan and durvalumab, given before surgery to people with stage III inflammatory breast cancer that has a protein called HER2. The goal is to see if the combination can eliminate all signs of cancer in the breast and lymph nodes at the…
Matched conditions: HER2-POSITIVE BREAST CANCER
Phase: PHASE2 • Sponsor: Filipa Lynce, MD • Aim: Disease control
Last updated May 26, 2026 02:13 UTC
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Immune cells engineered to fight advanced breast cancer enter human trials
Disease control Recruiting nowThis study tests a new treatment using specially designed immune cells (CAR-NK cells) that target specific markers on breast cancer cells. It is for people with advanced or metastatic breast cancer, including HER2-positive and triple-negative types, who have tried other treatment…
Matched conditions: HER2-POSITIVE BREAST CANCER
Phase: PHASE1, PHASE2 • Sponsor: Beijing Biotech • Aim: Disease control
Last updated May 26, 2026 02:13 UTC
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New hope for Hard-to-Treat breast cancer that spreads to the brain
Disease control Recruiting nowThis study tests a new drug (RO7771950) combined with two standard treatments for people with advanced HER2-positive breast cancer that has spread or cannot be removed by surgery. The new drug is designed to reach the brain, which is important because this cancer often spreads th…
Matched conditions: HER2-POSITIVE BREAST CANCER
Phase: PHASE2, PHASE3 • Sponsor: Hoffmann-La Roche • Aim: Disease control
Last updated May 26, 2026 02:12 UTC
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New hope for breast cancer patients with rare brain and spine spread
Disease control Recruiting nowThis study tests whether combining targeted drugs (tucatinib, trastuzumab, and capecitabine) with radiation to the brain and/or spine is safe and effective for people with HER2-positive breast cancer that has spread to the lining of the brain and spinal cord (leptomeningeal disea…
Matched conditions: HER2-POSITIVE BREAST CANCER
Phase: PHASE2 • Sponsor: Sunnybrook Health Sciences Centre • Aim: Disease control
Last updated May 26, 2026 02:11 UTC
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New breast cancer drug tested in real-world setting
Disease control Recruiting nowThis study is looking at how well a drug called trastuzumab-rezetecan works and how safe it is for people with HER2-positive or HER2-low breast cancer. About 300 adults who are already scheduled to receive this drug as part of their care will be followed. Researchers will track s…
Matched conditions: HER2-POSITIVE BREAST CANCER
Sponsor: Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University • Aim: Disease control
Last updated May 26, 2026 02:10 UTC
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New drug combo aims to wipe out HER2 breast cancer before surgery
Disease control Recruiting nowThis study tests a new drug called BL-M07D1, with or without another drug (pertuzumab), against standard chemotherapy for HER2-positive breast cancer before surgery. About 120 women with stage II or III breast cancer will take part. The goal is to see if the new combination can c…
Matched conditions: HER2-POSITIVE BREAST CANCER
Phase: PHASE2, PHASE3 • Sponsor: Sichuan Baili Pharmaceutical Co., Ltd. • Aim: Disease control
Last updated May 22, 2026 14:00 UTC
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Immune cell combo shows promise in Hard-to-Treat breast cancer
Disease control Recruiting nowThis early-phase study tests whether giving a special immune cell treatment after a vaccine and two standard drugs is safe for people with advanced HER2-positive breast cancer. About 28 participants will receive the combination therapy. The goal is to find the best dose and see i…
Matched conditions: HER2-POSITIVE BREAST CANCER
Phase: PHASE1 • Sponsor: H. Lee Moffitt Cancer Center and Research Institute • Aim: Disease control
Last updated May 22, 2026 13:55 UTC
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New drug combo tested for tough breast cancers that Don't fully respond
Disease control Recruiting nowThis study tests whether a different combination of targeted drugs works better for women with a certain type of breast cancer (HER2-positive, hormone receptor-positive) that still shows signs of cancer after initial treatment. About 300 women will receive either the standard two…
Matched conditions: HER2-POSITIVE BREAST CANCER
Phase: PHASE3 • Sponsor: Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University • Aim: Disease control
Last updated May 20, 2026 11:56 UTC
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New hope for HER2+ breast cancer: phase 3 trial compares next-gen drug to standard therapy
Disease control Recruiting nowThis phase 3 trial tests whether a new drug, BL-M07D1, works better than the current standard (T-DM1) for people with HER2-positive breast cancer that still has invasive cancer after initial chemotherapy. About 1,450 women aged 18-75 will be randomly assigned to one of the two tr…
Matched conditions: HER2-POSITIVE BREAST CANCER
Phase: PHASE3 • Sponsor: Sichuan Baili Pharmaceutical Co., Ltd. • Aim: Disease control
Last updated May 19, 2026 11:59 UTC
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New hope for HER2+ breast cancer: phase 3 trial compares TQB2102 to standard therapy
Disease control Recruiting nowThis phase 3 trial tests whether a new drug, TQB2102, works better than the standard TCbHP regimen for shrinking HER2-positive breast tumors before surgery. About 544 participants will receive either treatment and then have their tumors assessed for complete response. The goal is…
Matched conditions: HER2-POSITIVE BREAST CANCER
Phase: PHASE3 • Sponsor: Chia Tai Tianqing Pharmaceutical Group Nanjing Shunxin Pharmaceutical Co., Ltd. • Aim: Disease control
Last updated May 18, 2026 12:13 UTC
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New drug combo shows promise for tough breast cancer
Disease control Recruiting nowThis early-phase study tests two drugs, palbociclib and avelumab, together for people with a specific type of advanced breast cancer (AR+ triple-negative). The main goals are to find the safest doses and see if the combination can shrink tumors. About 45 participants with advance…
Matched conditions: HER2-POSITIVE BREAST CANCER
Phase: PHASE1 • Sponsor: Royal Marsden NHS Foundation Trust • Aim: Disease control
Last updated May 18, 2026 12:12 UTC
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Heart drug may shield breast cancer patients from chemo side effect
Disease control Recruiting nowThis study tests whether a heart medication called nebivolol can prevent heart damage caused by trastuzumab, a common breast cancer treatment. Researchers will give 56 women with HER2-positive breast cancer either nebivolol or a placebo alongside their cancer therapy. The goal is…
Matched conditions: HER2-POSITIVE BREAST CANCER
Phase: PHASE2 • Sponsor: Ain Shams University • Aim: Disease control
Last updated May 18, 2026 12:11 UTC
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New pill takes on hard-to-treat HER2 cancers, including brain tumors
Disease control Recruiting nowThis early-phase trial tests an experimental drug called IAM1363 in people with advanced cancers that have HER2 alterations. The study aims to find a safe dose and see if the drug can shrink tumors, including those that have spread to the brain. About 383 adults whose cancer has …
Matched conditions: HER2-POSITIVE BREAST CANCER
Phase: PHASE1 • Sponsor: Iambic Therapeutics, Inc • Aim: Disease control
Last updated May 18, 2026 12:10 UTC
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New hope for advanced breast cancer: phase 3 trial of IBI354 launches
Disease control Recruiting nowThis phase 3 trial tests a new drug called IBI354, given with or without another drug (pertuzumab), against the current standard treatment for people with advanced HER2-positive breast cancer that cannot be removed by surgery. The study aims to see if the new combination helps de…
Matched conditions: HER2-POSITIVE BREAST CANCER
Phase: PHASE3 • Sponsor: Innovent Biopharmaceutical Technology (Hangzhou) Co., LTD. • Aim: Disease control
Last updated May 18, 2026 12:06 UTC
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New drug cocktail aims to wipe out breast cancer before surgery
Disease control Recruiting nowThis study tests whether giving a combination of three drugs (neratinib, an aromatase inhibitor, and trastuzumab) for 24 weeks before surgery can eliminate all signs of cancer in the breast tissue of people with ER-positive, HER2-positive breast cancer. About 30 postmenopausal wo…
Matched conditions: HER2-POSITIVE BREAST CANCER
Phase: PHASE2 • Sponsor: Ruth O'Regan • Aim: Disease control
Last updated May 15, 2026 11:54 UTC
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New combo therapy aims to fight deadly breast cancer spread to the brain
Disease control Recruiting nowThis study tests if radiation therapy followed by two targeted drugs (trastuzumab and pertuzumab) given directly into the spinal fluid is safe and helps people with HER2+ breast cancer that has spread to the lining of the brain and spinal cord (leptomeningeal disease). About 39 p…
Matched conditions: HER2-POSITIVE BREAST CANCER
Phase: PHASE1, PHASE2 • Sponsor: H. Lee Moffitt Cancer Center and Research Institute • Aim: Disease control
Last updated May 14, 2026 12:06 UTC
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New hope for nigerian women: targeted breast cancer therapy before and after surgery
Disease control Recruiting nowThis study is for Nigerian women with a specific type of breast cancer called HER2-positive. Doctors want to see if giving a combination of targeted drugs before and after surgery can destroy the cancer completely. About 74 women will receive the treatment, and researchers will c…
Matched conditions: HER2-POSITIVE BREAST CANCER
Phase: PHASE2 • Sponsor: University of Chicago • Aim: Disease control
Last updated May 11, 2026 20:48 UTC
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New Light-Based device could spare breast cancer patients from unnecessary surgery
Diagnosis Recruiting nowThis study tests a new imaging system that uses light to monitor how well breast cancer responds to chemotherapy before surgery. Researchers want to see if it can accurately predict when the cancer is completely gone, which could help some patients avoid additional treatments. Th…
Matched conditions: HER2-POSITIVE BREAST CANCER
Phase: NA • Sponsor: Indiana University • Aim: Diagnosis
Last updated May 22, 2026 13:54 UTC
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Cheaper scan may rival MRI for spotting chemo success in breast cancer
Diagnosis Recruiting nowThis study compares a contrast-enhanced digital mammogram (CEDM+CEDBT) with standard breast MRI to see if it can accurately predict whether breast cancer has been eliminated by chemotherapy before surgery. About 30 women with locally advanced breast cancer will get 1-2 of these s…
Matched conditions: HER2-POSITIVE BREAST CANCER
Phase: EARLY_PHASE1 • Sponsor: Alison Stopeck • Aim: Diagnosis
Last updated May 22, 2026 13:53 UTC
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Could a simple test make breast cancer treatment smarter?
Diagnosis Recruiting nowThis study tests whether a diagnostic test called HER2DX can help doctors choose the best treatment for people with early-stage HER2-positive breast cancer. About 304 participants will be split into two groups: one gets standard treatment without the test results, and the other g…
Matched conditions: HER2-POSITIVE BREAST CANCER
Phase: NA • Sponsor: Fundacio Clinic Barcelona • Aim: Diagnosis
Last updated May 13, 2026 16:03 UTC
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Gut bacteria may tame chemo side effect in breast cancer patients
Symptom relief Recruiting nowThis study tests whether taking probiotics can help prevent severe diarrhea in women with HER2-positive breast cancer who are taking the drug Neratinib. About 308 participants will be randomly assigned to receive either probiotics or a placebo, along with standard diarrhea preven…
Matched conditions: HER2-POSITIVE BREAST CANCER
Phase: NA • Sponsor: Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University • Aim: Symptom relief
Last updated May 18, 2026 12:07 UTC
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Scientists dig into tumor samples to crack resistance in HER2 breast cancer
Knowledge-focused Recruiting nowThis study examines stored tumor samples from 10 people with HER2-positive breast cancer who still had cancer after standard chemo and trastuzumab. Researchers will compare samples taken before and after treatment to see how the tumor and its surroundings changed. The goal is to …
Matched conditions: HER2-POSITIVE BREAST CANCER
Sponsor: Giampaolo Bianchini • Aim: Knowledge-focused
Last updated May 26, 2026 02:22 UTC
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Real-World data sought on breast cancer drug in russia
Knowledge-focused Recruiting nowThis study will collect and analyze real-world medical records from 60 Russian adults with advanced HER2-positive breast cancer who have already received at least one cycle of trastuzumab deruxtecan. The goal is to see how well the drug works in everyday practice, including how l…
Matched conditions: HER2-POSITIVE BREAST CANCER
Phase: NA • Sponsor: Blokhin's Russian Cancer Research Center • Aim: Knowledge-focused
Last updated May 26, 2026 02:20 UTC
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Brain scans could spot hidden cancer spread in breast cancer patients
Knowledge-focused Recruiting nowThis study looks at whether routine brain MRIs can find cancer that has spread to the brain in people with metastatic or inflammatory breast cancer. About 214 participants will get screening MRIs to see how often brain metastases occur and how they affect quality of life. The goa…
Matched conditions: HER2-POSITIVE BREAST CANCER
Phase: NA • Sponsor: Brigham and Women's Hospital • Aim: Knowledge-focused
Last updated May 26, 2026 02:10 UTC
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Breast cancer trial aims to match drugs to tumors with High-Tech imaging
Knowledge-focused Recruiting nowThis study is testing whether adding new experimental drugs to standard chemotherapy before surgery can improve outcomes for people with breast cancer. It includes up to 5,000 participants with early-stage or locally advanced breast cancer. The goal is to use MRI scans and tissue…
Matched conditions: HER2-POSITIVE BREAST CANCER
Phase: PHASE2 • Sponsor: QuantumLeap Healthcare Collaborative • Aim: Knowledge-focused
Last updated May 22, 2026 13:54 UTC
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Whole-Body MRI may spot hidden breast cancer spread sooner
Knowledge-focused Recruiting nowThis study tests whether a type of whole-body MRI (DWB-MRI) can detect the return or spread of breast cancer earlier than standard scans. Researchers will follow 145 people with high-risk breast cancer (HER2+ or triple-negative) for 5 years to see if early detection leads to bett…
Matched conditions: HER2-POSITIVE BREAST CANCER
Phase: NA • Sponsor: European Institute of Oncology • Aim: Knowledge-focused
Last updated May 22, 2026 13:50 UTC
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Brain scans for silent metastases: a new screening strategy for advanced breast cancer
Knowledge-focused Recruiting nowThis study is testing whether regular brain MRIs can detect cancer that has spread to the brain in people with stage IV breast cancer who have no brain symptoms. About 170 participants with different breast cancer subtypes will get brain scans at the start and again at 6 months o…
Matched conditions: HER2-POSITIVE BREAST CANCER
Phase: PHASE2 • Sponsor: H. Lee Moffitt Cancer Center and Research Institute • Aim: Knowledge-focused
Last updated May 20, 2026 11:56 UTC
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Blood test may predict chemo success in breast cancer
Knowledge-focused Recruiting nowThis study looks at whether a blood test that measures circulating tumor DNA (ctDNA) can help predict how well breast cancer responds to chemotherapy before surgery. Researchers will take blood samples from 125 women with stage II or III breast cancer before, during, and after tr…
Matched conditions: HER2-POSITIVE BREAST CANCER
Sponsor: Gene Solutions • Aim: Knowledge-focused
Last updated May 18, 2026 12:09 UTC