Brain MRI screening for breast cancer: a new way to catch metastases early?
NCT ID NCT06247449
First seen Jan 11, 2026 · Last updated Jun 19, 2026 · Updated 20 times
Summary
This study is looking at whether a brain MRI can spot cancer that has spread to the brain in people with certain types of breast cancer (triple negative or HER2-positive, stage IIb or III) who have no symptoms. About 100 participants will get a contrast-enhanced brain MRI, give a blood sample, and fill out a questionnaire about how they feel about the scan. The goal is to find out how common hidden brain metastases are and whether patients find the screening acceptable.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Sunnybrook Health Science Centre
RECRUITINGToronto, Ontario, M4N 3M5, Canada
Contact Phone: •••-•••-•••• Email: •••••@•••••
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Contrast-enhanced brain MRI and blood test for circulating tumor DNA
What this could lead to
If successful, this could show that routine MRI screening helps detect brain metastases early in high-risk breast cancer patients, potentially guiding earlier treatment.
What could go wrong
This is a small, early-stage observational study (100 participants) that only measures how often hidden brain metastases occur and patient attitudes—it does not test whether earlier detection improves outcomes or survival.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.