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New Pill-and-Shot combo aims to wipe out HER2+ breast cancer before surgery

NCT ID NCT07095023

First seen May 02, 2026 · Last updated Jun 17, 2026 · Updated 6 times

Summary

This study tests whether taking an oral chemotherapy (paclitaxel) along with a fixed-dose injection of two targeted drugs (pertuzumab and trastuzumab) can eliminate all signs of HER2-positive breast cancer before surgery. About 112 adults with early-stage HER2+ breast cancer will receive this combination before their operation. The main goal is to see if the cancer completely disappears in the breast and lymph nodes at the time of surgery.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Cancer Hospital of Shantou University Medical College

    NOT_YET_RECRUITING

    Shantou, Guangdong, China

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Guangdong Women and children Hospital

    NOT_YET_RECRUITING

    Guangzhou, Guangdong, China

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Guangxi Provincial Cancer Hospital

    NOT_YET_RECRUITING

    Nanning, Guangxi, China

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Hainan Central Hospital

    NOT_YET_RECRUITING

    Haikou, Hainan, China

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Peking University Cancer Hospital

    NOT_YET_RECRUITING

    Beijing, Beijing Municipality, China

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Peking University Shenzhen Hospita

    NOT_YET_RECRUITING

    Shenzhen, China

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Sun Yat-sen Memorial Hospital

    RECRUITING

    Guangzhou, Guangdong, China

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • The Affiliated Hospital of Guizhou Medical University

    NOT_YET_RECRUITING

    Guiyang, Guizhou, China

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • the First Affiliated Hospital of Wenzhou Medical University

    NOT_YET_RECRUITING

    Wenzhou, Zhejiang, China

    Contact Phone: •••-•••-•••• Email: •••••@•••••

Conditions

The condition(s) this trial relates to.

breast cancer breast neoplasm HER2 positive breast carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.