Sun Yat-sen Memorial Hospital Of Sun Yat-sen University

This study is observing 300 patients with HER2-positive or HER2-low breast cancer who are already receiving or scheduled to receive trastuzumab-rezetecan treatment in real-world clinical settings. The goal is to collect information about how well the treatment works and what side…

This early-stage study is testing a new type of personalized immune cell therapy for people with advanced solid tumors, like pancreatic cancer, that have specific KRAS gene mutations. Doctors will collect a patient's own T-cells, modify them in a lab to better recognize and attac…

This early-phase study is testing a new type of personalized cell therapy for people with advanced soft tissue or bone cancers that have stopped responding to standard treatments. Doctors will collect a patient's own immune cells, genetically modify them in a lab to recognize a s…

This study is testing whether adding the medication hydroxychloroquine to standard thyroid hormone treatment helps women with recurrent pregnancy loss have successful pregnancies. Researchers will compare the two-drug combination against thyroid hormone treatment alone in nearly …

This study is testing if adding a clot-busting drug directly into a blocked brain artery during a standard stroke surgery leads to better recovery. It will involve 530 adults who have had a stroke caused by a blockage in a medium-sized brain artery within the last 24 hours. Half …

This study is testing a combination of three drugs as a follow-up treatment for patients who have had surgery for a type of bile duct cancer that has spread to nearby lymph nodes. The goal is to see if this drug mix can help prevent the cancer from coming back and help patients l…

This study is testing whether a genetic test called RecurIndex can help doctors decide which breast cancer patients need radiation to their lymph nodes after surgery. It aims to see if patients with a low-risk genetic score can safely skip this radiation, potentially reducing sid…

This study is testing if a personalized, two-drug treatment works better than the standard single drug for people with a severe type of rheumatoid arthritis (RA). Researchers will enroll 130 adults with this specific 'myeloid-stromal' type of RA. One group will receive the standa…

This study compares two different drug combinations to see which works better at preventing breast cancer from coming back after initial treatment. It's for women with a specific type of breast cancer (HER2-positive) who still have a small amount of cancer after their first round…

This study compares two surgical approaches for thyroid cancer that has spread to neck lymph nodes. It tests whether a newer robotic technique performed through a single armpit incision provides similar cancer control and better quality of life than traditional open neck surgery,…

This study is observing whether women with specific types of early-stage breast cancer can safely avoid radiation to their lymph nodes after surgery. Researchers are following 635 patients who have hormone-sensitive, HER2-negative tumors with 1-3 positive lymph nodes and a specia…

This study is testing a new combination of three drugs as the first treatment for advanced bile duct cancer that cannot be removed by surgery. The goal is to see if adding two newer drugs (apatinib and adebrelimab) to standard chemotherapy can shrink tumors better and help patien…

This study is testing if a clot-busting drug called tenecteplase is safe and helps people recover better after a stroke, specifically for patients who were recently taking common blood thinners (DOACs). About 912 participants will be randomly assigned to receive either the drug o…

This study is testing whether the breast cancer drug T-DM1 can be safely given to patients who previously developed low platelet counts (thrombocytopenia) from chemotherapy. Researchers will enroll 56 breast cancer patients whose platelet counts have recovered after experiencing …

This Phase 3 trial compares two combination treatments for advanced liver cancer that has spread. One approach uses standard intravenous chemotherapy plus immunotherapy and targeted therapy. The other delivers chemotherapy directly to the liver through an artery before adding the…

This study is testing a new treatment plan for people with advanced breast cancer that has stopped responding to standard hormone-based drugs. It will give 45 participants a newer targeted drug first, and then switch them to a different combination of pills. The main goal is to s…

This study is for people with advanced triple-negative breast cancer whose disease is stable or shrinking after initial treatment. It aims to see if continuing immunotherapy with longer time between doses works as well as the standard schedule at keeping the cancer under control.…

This study is testing a new artificial intelligence (AI) tool designed to help doctors detect when cancer has spread to a patient's lymph nodes. The AI will analyze digital images of lymph node tissue from 10,000 cancer patients and its findings will be compared to standard patho…

This study is testing a new artificial intelligence (AI) tool designed to help surgeons during thyroid surgery. The AI is trained to spot tiny, hard-to-find glands and predict their blood flow from the surgical camera feed. The goal is to help surgeons avoid damaging these glands…

This study is looking at whether a special type of ultrasound scan can help doctors better predict if and how much early thyroid cancer has spread to nearby lymph nodes before surgery. Researchers will review the scans and medical records of 600 past patients to see if the scan's…

This study is testing whether two non-drug methods—acupuncture and compression sleeves—can prevent nerve damage (peripheral neuropathy) caused by a common type of breast cancer chemotherapy. Researchers will compare the two methods alone and together in 384 patients to see which …

This study is testing whether a special oil applied to the skin can safely reduce severe breast pain in premenopausal women. Researchers will compare the oil to a placebo (an inactive substance) in about 190 participants to see which one works better. The main goal is to see if t…

This study is testing whether a non-invasive brain stimulation technique, combined with hearing aids, can help improve memory and thinking skills in older adults with age-related hearing loss. Researchers will compare three groups: people with hearing loss who don't use hearing a…

This study aims to find the best pain relief combination for patients recovering from oral cancer surgery. Researchers will compare two different painkiller mixes given through patient-controlled pumps after surgery. They want to see which provides better pain control with fewer …

This study is testing whether a personalized form of brain stimulation works better than the standard method to reduce the symptoms of chronic tinnitus. Researchers will use MRI brain scans to find a unique target for each participant before delivering a non-invasive magnetic sti…

This study is testing if a combination of two shockwave therapy techniques works better than a single technique for treating patellar tendinitis, a common cause of knee pain. Researchers will compare pain levels and knee function in two groups of adults over three months. The goa…

This study is testing whether probiotic supplements can help prevent severe diarrhea in people with HER2-positive breast cancer who are taking the drug neratinib. About 308 participants will be randomly assigned to take either probiotics or a placebo, while all will also receive …

This observational study aims to understand the genetic patterns in Chinese women with HER2-low breast cancer. Researchers will analyze tumor samples from 255 patients to see how specific gene changes relate to survival outcomes. The study does not test any new treatments—it only…

This study aims to learn what happens when doctors simply monitor patients with a mild form of chronic breast inflammation instead of starting treatment immediately. Researchers will follow 57 women to see how often and how quickly the condition gets worse during this 'watchful w…

This study aims to test and validate two different symptom scoring tools for a chronic, painful breast inflammation condition called non-lactational mastitis. Researchers will enroll 300 women to see how well a doctor's score and a patient's own symptom report can reliably measur…