Could a daily supplement fight chemobrain? new study investigates
NCT ID NCT07465497
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looks at whether taking synbiotics (probiotics plus a prebiotic from agave) or prebiotics alone can help prevent memory and thinking problems (chemobrain) in people with breast cancer getting chemotherapy. About 80 participants will take a supplement or none daily for 4 months, and their thinking skills and inflammation levels will be checked. The goal is to find a safe, simple way to protect brain function during cancer treatment.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 80 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Feb 2026
- Expected to finish
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Feb 2027
An estimate. End dates often move.
- Lead sponsor
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A government agency
The lead sponsor is a government body.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Female participants only
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Age: Participants must be between 18 and 75 years old. * Diagnosis: Must have a confirmed diagnosis of breast cancer at stages IB to IIIC. * Treatment Status: Participants should be scheduled to receive neoadjuvant chemotherapy as part of their treatment plan. * Cognitive Function: Must demonstrate baseline cognitive function as assessed by the CERAD neuropsychological battery, indicating no severe cognitive impairment. * Informed Consent: Participants must provide written informed consent to participate in the study and comply with all study procedures. * Health Status: Should not have any significant comorbidities that could interfere with the study outcomes, such as severe psychiatric disorders or neurological conditions. * No Previous Probiotic Use: Must not have used probiotics or prebiotics in the month prior to the study Exclusion Criteria: * Severe Cognitive Impairment: Participants with significant cognitive impairment or dementia as assessed by the CERAD neuropsychological battery will be excluded. * Severe Comorbidities: Participants with serious comorbid conditions, such as uncontrolled diabetes, severe cardiovascular diseases, or active infections, will be excluded. * Psychiatric Disorders: Individuals with a history of severe psychiatric disorders that could affect cognitive function or compliance with the study protocol will be excluded. * Neurological Conditions: Participants with neurological disorders such as multiple sclerosis, Parkinson's disease, or other conditions that affect cognitive function will be excluded. * Pregnant or Lactating Women: Pregnant or breastfeeding women will not be eligible to participate in the study. * Allergies: Individuals with known allergies to any of the components of the synbiotics or prebiotics used in the study will be excluded. * Non-compliance Risk: Participants who are deemed at risk of non-compliance with study procedures or follow-up will be excluded.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
The full official record for this study. This one lists no contact details, but it is the first place any would appear.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Instituto Oncológico Nacional
Zapopan, Jalisco, 44660, Mexico
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Other studies related to the condition(s) this trial covers.
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